7 recruiting, 4 active not recruiting, 3 not yet recruiting, 1 completed. 11 Not applicable, 2 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 11 | Active not recruiting 4, Not yet recruiting 3, Recruiting 3, Completed 1 |
| Phase 1 | 2 | Recruiting 2 |
| Phase 2 | 1 | Recruiting 1 |
Follow Histotripsy: new trials by email Literature Review of Histotripsy trials Research Report on Histotripsy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Histotripsy in Biliary Tract Cancer Gemcitabine, Cisplatin, Durvalumab - Biliary Track Cancer | Not applicable | Recruiting | NYU Langone Health | 24 | 2026-10-05 | 2026-10-20 |
| Combination Therapy Using Durvalumab and Histotripsy for Treatment of Intrahepatic Cholangiocarcinoma Histotripsy, Durvalumab, Biopsy - Intrahepatic Cholangiocarcinoma | Phase 2 | Recruiting | University of Wisconsin, Madison | 12 | 2026-10-01 | 2026-10-13 |
| Histotripsy for Peritoneal Tumour and Lymph Node: a Pilot Study Histotripsy - Lymph Nodes, Peritoneal Tumour | Not applicable | Not yet recruiting | The University of Hong Kong | 30 | 2026-10-01 | 2026-10-14 |
| Histotripsy x Pancreatic Cancer Histotripsy - Pancreatic Tumours | Not applicable | Recruiting | The University of Hong Kong | 20 | 2026-03-31 | 2026-10-14 |
| The Edison System for Treatment of Benign Prostatic Hyperplasia (BPH) Using Histotripsy HistoSonics Edison System - Benign Prostatic Hyperplasia | Not applicable | Recruiting | HistoSonics, Inc. | 80 | 2026-03-20 | 2026-04-09 |
| To Evaluate the Safety and Efficacy of Histotripsy for the Symptom Relief of Inoperable Abdominal Tumors Histotripsy - Abdominal Tumors | Not applicable | Not yet recruiting | National Taiwan University Hospital | 30 | 2025-10-01 | 2025-09-18 |
| Evaluation of Circulating Immune Response After Histosonics in Colorectal Cancer (ECHO-CRC) Histotripsy - Colorectal (Colon or Rectal) Cancer | Phase 1 | Recruiting | Northwell Health | 12 | 2025-09-26 | 2026-01-22 |
| Safety and Clinical Efficacy of Histotripsy for Liver Cancers Adjacent to Major Intrahepatic Vessels Histotripsy - Liver Tumors | Not applicable | Not yet recruiting | National Taiwan University Hospital | 20 | 2025-08-01 | 2025-07-14 |
| Real-world Evaluation of the HistoSonics Edison System for Treatment of Liver Tumors Across Multidisciplinary Users (BOOMBOX: Master Study) HistoSonics Edison System - Liver Neoplasms, Primary Liver Cancer | Recruiting | HistoSonics, Inc. | 5000 | 2024-10-14 | 2026-09-11 | |
| Histotripsy (HistoSonics®) for Liver Tumours Histotripsy - Liver Tumour | Not applicable | Active not recruiting | The University of Hong Kong | 60 | 2024-08-29 | 2025-12-16 |
| A Study of Pembrolizumab and Ablation (Cryoablation or Histotripsy) in People With Breast Cancer Pembrolizumab, Cryoablation, Histotripsy - Metastatic Breast Cancer, Breast Cancer | Phase 1 | Recruiting | Memorial Sloan Kettering Cancer Center | 30 | 2024-01-29 | 2026-09-14 |
| The HistoSonics Edison™ System for Treatment of Primary Solid Renal Tumors Using Histotripsy (#HOPE4KIDNEY) HistoSonics Edison System - Renal Cancer, Tumor, Solid | Not applicable | Active not recruiting | HistoSonics, Inc. | 67 | 2024-01-04 | 2026-06-23 |
| The HistoSonics Investigational System for Treatment of Primary Solid Renal Tumors Using Histotripsy HistoSonics Investigational System - Renal Cancer, Tumor, Solid | Not applicable | Completed | HistoSonics, Inc. | 20 | 2023-03-23 | 2026-09-11 |
| The HistoSonics System for Treatment of Primary and Metastatic Liver Tumors Using Histotripsy (#HOPE4LIVER EU/UK) HistoSonics System - Liver Neoplasms, Hepatocellular Carcinoma | Not applicable | Active not recruiting | HistoSonics, Inc. | 24 | 2021-06-04 | 2026-01-12 |
| The HistoSonics System for Treatment of Primary and Metastatic Liver Tumors Using Histotripsy HistoSonics System - Liver Neoplasms, Hepatocellular Carcinoma | Not applicable | Active not recruiting | HistoSonics, Inc. | 47 | 2021-01-27 | 2025-11-19 |
Carcinoma, Hepatocellular (5) · Liver Neoplasms (3) · Kidney Neoplasms (2) · Neoplasms (2) · Abdominal Neoplasms (1) · Breast Neoplasms (1) · Cholangiocarcinoma (1) · Colonic Neoplasms (1) · Pancreatic Diseases (1) · Pancreatic Neoplasms (1) · Prostatic Hyperplasia (1) · Triple Negative Breast Neoplasms (1)
HistoSonics, Inc. (6) · The University of Hong Kong (3) · National Taiwan University Hospital (2) · Memorial Sloan Kettering Cancer Center (1) · NYU Langone Health (1) · Northwell Health (1) · University of Wisconsin, Madison (1)
United States (7) · Hong Kong (4) · United Kingdom (2) · Germany (1) · Italy (1) · Spain (1) · Taiwan (1)
Albert Chan, MS (1) · Clifford S Cho, MD (1) · John Swietlik, MD (1) · Kristen Spencer, DO, MPH (1) · Luigi A Solbiati, MD (1) · Timothy J Ziemlewicz, MD (1) · Yolanda Bryce, MD (1)