9 completed, 3 recruiting, 2 unknown, 1 not yet recruiting. 5 Phase 3, 4 Phase 1, 3 Phase 2, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Completed 4, Not yet recruiting 1 |
| Phase 1 | 4 | Completed 4 |
| Phase 2 | 3 | Recruiting 2, Completed 1 |
| Phase 4 | 1 | Recruiting 1 |
Follow eravacycline: new trials by email Literature Review of eravacycline trials Research Report on eravacycline
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Targeted Versus Standard Peri-operative Antibiotic Prophylaxis in Patients Colonized With Carbapenemase Producing Enterobacterales Undergoing Liver Transplantation Ceftazidime - Avibactam ( CAZ-AVI), Meropenem-Vaborbactam, Imipenem+Relebactam - Liver Transplant, Carbapenem-resistant Enterobacterales | Phase 3 | Not yet recruiting | IRCCS Azienda Ospedaliero-Universitaria di Bologna | 168 | 2026-10-01 | 2026-08-12 |
| A Study to Evaluate the Safety and Tolerability of Eravacycline in Pediatric Patients Aged 8 to 17 With Complicated Intra-abdominal Infections (cIAI) IV Eravacycline 2mg/kg, IV Eravacycline 1.5mg/kg - Complicated Intra-abdominal Infections (cIAI) | Phase 2 | Recruiting | Tetraphase Pharmaceuticals, Inc | 35 | 2025-05-22 | 2026-05-05 |
| Therapeutic Options for CRAB Fosfomycin, Eravacycline, ampicillin/sulbactam - Infections, Bacterial, Sepsis Bacterial | Phase 4 | Recruiting | Clinical Hospital Centre Zagreb | 108 | 2025-01-30 | 2026-01-21 |
| Prospective Evaluation of Xerava Prophylaxis in Hematological Malignancy Patients With Prolonged Neutropenia Eravacycline - Hematological Malignancy, Neutropenia | Phase 2 | Recruiting | West Virginia University | 55 | 2024-02-19 | 2026-04-16 |
| Efficacy and Safety of the Combination Therapy Based on Eravacycline in Immunocompromised Hosts With MDROS Infection Eravacycline - Immune Dysregulation Disorder | Unknown | Sichuan Provincial People's Hospital | 100 | 2024-02-01 | 2024-01-25 | |
| Eravacycline Combination Therapy for MRAB Eravacycline Injection - Pulmonary Infection, Pneumonia, Bacterial | Unknown | Fujian Medical University Union Hospital | 20 | 2024-01-26 | 2024-02-28 | |
| A Safety and PK Study of IV Eravacycline Eravacycline (TP-434) - Bacterial Infections | Phase 1 | Completed | Tetraphase Pharmaceuticals, Inc | 19 | 2018-12-20 | 2021-12-03 |
| Efficacy and Safety Study of Eravacycline Compared With Ertapenem in Participants With Complicated Urinary Tract Infections Eravacycline, Ertapenem, Placebo - Complicated Urinary Tract Infections | Phase 3 | Completed | Tetraphase Pharmaceuticals, Inc | 1205 | 2017-01-01 | 2022-01-06 |
| Efficacy and Safety Study of Eravacycline Compared With Meropenem in Complicated Intra-abdominal Infections Eravacycline, Meropenem, Placebo - Complicated Intra-abdominal Infections, Complicated Appendicitis | Phase 3 | Completed | Tetraphase Pharmaceuticals, Inc | 500 | 2016-10-13 | 2022-01-06 |
| Efficacy and Safety Study of Eravacycline Compared With Levofloxacin in Complicated Urinary Tract Infections Eravacycline, Levofloxacin - cUTI | Phase 3 | Completed | Tetraphase Pharmaceuticals, Inc | 908 | 2014-10-06 | 2022-01-11 |
| A Phase 1, Open-Label Study to Assess the Single-Dose Pharmacokinetics of Eravacycline in Subjects With End Stage Renal Disease and Healthy Subjects eravacycline - End Stage Renal Disease | Phase 1 | Completed | Tetraphase Pharmaceuticals, Inc | 12 | 2013-12-01 | 2021-12-17 |
| A Phase 1, Open-Label Study to Assess the Single-Dose Pharmacokinetics of Eravacycline in Subjects With Impaired Hepatic Function and Healthy Subjects eravacycline - Impaired Hepatic Function | Phase 1 | Completed | Tetraphase Pharmaceuticals, Inc | 24 | 2013-10-01 | 2021-12-17 |
| Efficacy and Safety Study of Eravacycline Compared With Ertapenem in Complicated Intra-abdominal Infections Eravacycline, Ertapenem, Placebo - Complicated Intra-abdominal Infections | Phase 3 | Completed | Tetraphase Pharmaceuticals, Inc | 541 | 2013-08-01 | 2022-01-11 |
| Safety and Pharmacokinetic (PK) Study to Assess Bronchopulmonary Disposition of IV Eravacycline (TP-434) in Healthy Men and Women TP-434 (Eravacycline) reconstituted and administered via an IV infusion - Normal Drug Tolerance | Phase 1 | Completed | Tetraphase Pharmaceuticals, Inc | 20 | 2012-11-01 | 2021-12-17 |
| Study to Compare TP-434 and Ertapenem in Community-acquired Complicated Intra-abdominal Infections TP-434, Ertapenem, Placebo - Complicated Intra-abdominal Infection | Phase 2 | Completed | Tetraphase Pharmaceuticals, Inc | 143 | 2011-01-01 | 2022-01-06 |
Bacterial Infections (2) · Hematologic Neoplasms (1) · Infections (1) · Kidney Failure, Chronic (1) · Neutropenia (1) · Pneumonia, Bacterial (1)
Tetraphase Pharmaceuticals, Inc (10) · Clinical Hospital Centre Zagreb (1) · Fujian Medical University Union Hospital (1) · IRCCS Azienda Ospedaliero-Universitaria di Bologna (1) · Sichuan Provincial People's Hospital (1) · West Virginia University (1)
United States (10) · Bulgaria (5) · Latvia (5) · Romania (5) · Estonia (4) · Russia (4) · Ukraine (4) · Czechia (3) · Georgia (3) · Hungary (3) · Lithuania (3) · Italy (2) · Moldova (2) · South Africa (2) · Argentina (1)
Patrick T Horn, MD, PhD (3) · Aaron Cumpston, PharmD, BCOP (1) · Chris Galloway, MD (1) · Hui Zhang, PhD (1) · Maddalena Giannella, MD, PhD (1) · Thomas Marbury, MD (1) · William Smith, MD (1)
PMID 30561562, PMID 31570004, PMID 24342651, PMID 27851857, PMID 39878492
2025 (1)