8 terminated, 3 completed. 8 Phase 1, 7 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 8 | Terminated 6, Completed 2 |
| Phase 2 | 7 | Terminated 5, Completed 2 |
| Phase 3 | 1 | Terminated 1 |
Follow Entospletinib: new trials by email Literature Review of Entospletinib trials Research Report on Entospletinib
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Entospletinib Plus Intensive Induction/Consolidation Chemotherapy in Newly Diagnosed NPM1-mutated AML Entospletinib, Placebo, Cytarabine - Nucleophosmin 1-mutated Acute Myeloid Leukemia | Phase 3 | Terminated | Kronos Bio | 15 | 2021-11-24 | 2024-01-10 |
| Study of Entospletinib (ENTO) in Newly Diagnosed DLBCL Patients With aaIPI>=1 Treated by Chemiotherapy Entospletinib, Rituximab, Cyclophosphamide - DLBCL | Phase 1 / Phase 2 | Terminated | The Lymphoma Academic Research Organisation | 25 | 2017-07-26 | 2020-09-02 |
| Entospletinib and Obinutuzumab in Treating Patients With Relapsed Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Non-Hodgkin Lymphoma Entospletinib, Laboratory Biomarker Analysis, Obinutuzumab - Anemia, B-Cell Prolymphocytic Leukemia | Phase 1 / Phase 2 | Completed | Alexey Danilov, MD | 24 | 2017-07-17 | 2023-08-08 |
| Entospletinib (ENTO) as Monotherapy and in Combination With Chemotherapy in Japanese Adults Entospletinib, Daunorubicin, Cytarabine - Hematologic Malignancy, Acute Myeloid Leukemia | Phase 1 | Terminated | Gilead Sciences | 9 | 2017-05-19 | 2020-03-06 |
| Safety and Efficacy of the Combination of Tirabrutinib and Entospletinib With and Without Obinutuzumab in Adults With Chronic Lymphocytic Leukemia (CLL) Tirabrutinib, Entospletinib, Obinutuzumab - Chronic Lymphocytic Leukemia | Phase 2 | Completed | Gilead Sciences | 36 | 2017-04-06 | 2021-12-21 |
| Safety and Efficacy of Entospletinib (ENTO [GS-9973]) Combined With Vincristine (VCR) in Adult Participants With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma (NHL) Entospletinib, Vincristine - Non-Hodgkin Lymphoma | Phase 1 / Phase 2 | Terminated | Gilead Sciences | 10 | 2016-02-11 | 2019-04-17 |
| Pharmacokinetics of Entospletinib in Adults With Normal and Impaired Liver Function Entospletinib - Oncology | Phase 1 | Completed | Gilead Sciences | 56 | 2015-11-16 | 2019-07-26 |
| Entospletinib Monotherapy and in Combination With Chemotherapy in Adults With Acute Myeloid Leukemia (AML) Entospletinib, Daunorubicin, Cytarabine - Acute Myeloid Leukemia | Phase 1 / Phase 2 | Terminated | Gilead Sciences | 148 | 2015-07-01 | 2019-11-15 |
| Dose Escalation and Dose Expansion Study of Tirabrutinib in Combination With Other Targeted Anti-cancer Therapies in Adults With B-cell Malignancies Tirabrutinib, Idelalisib, Entospletinib - B-cell Malignancies | Phase 1 | Terminated | Gilead Sciences | 203 | 2015-06-16 | 2025-06-17 |
| Safety and Efficacy of Entospletinib With Vincristine and Dexamethasone in Adults With Relapsed or Refractory Acute Lymphoblastic Leukemia (ALL) Entospletinib, Vincristine, Dexamethasone - Acute Lymphoblastic Leukemia | Phase 1 / Phase 2 | Terminated | Gilead Sciences | 30 | 2015-05-06 | 2020-01-02 |
| Entospletinib in Combination With Idelalisib in Adults With Relapsed or Refractory Hematologic Malignancies Entospletinib, Idelalisib - Chronic Lymphocytic Leukemia, Mantle Cell Lymphoma | Phase 2 | Terminated | Gilead Sciences | 66 | 2013-06-20 | 2020-06-02 |
Leukemia, Lymphocytic, Chronic, B-Cell (3) · Leukemia, Myeloid, Acute (3) · Leukemia (2) · Lymphoma, Mantle-Cell (2) · Recurrence (2) · Anemia (1) · Hematologic Neoplasms (1) · Leukemia, Hairy Cell (1) · Leukemia, Prolymphocytic, B-Cell (1) · Lymphoma (1) · Lymphoma, B-Cell, Marginal Zone (1) · Lymphoma, Follicular (1) · Lymphoma, Large B-Cell, Diffuse (1) · Lymphoma, Non-Hodgkin (1) · Neoplasms (1)
Gilead Sciences (8) · Alexey Danilov, MD (1) · Kronos Bio (1) · The Lymphoma Academic Research Organisation (1)
United States (8) · Germany (5) · France (4) · Canada (3) · Belgium (1) · Brazil (1) · Czechia (1) · Hungary (1) · Israel (1) · Italy (1) · Japan (1) · New Zealand (1) · Poland (1) · South Korea (1) · Spain (1)
Craig Okada, M.D. (1) · Emmanuelle Tchernonog (1) · Gilles Salles (1) · Julien Depaus (1)
PMID 26968534, PMID 28178345, PMID 34196037
2015 (3), 2016 (3)