6 completed, 3 unknown, 2 terminated, 1 recruiting. 10 Phase 2, 2 Not applicable, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 10 | Completed 5, Unknown 3, Recruiting 1, Terminated 1 |
| Not applicable | 2 | Completed 1, Terminated 1 |
| Phase 1 | 2 | Completed 2 |
Follow Donor lymphocytes: new trials by email Literature Review of Donor lymphocytes trials Research Report on Donor lymphocytes
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study Using Subject-specific MRD to Adopt Treatment After HSCT for Subjects With MDS Azacitidine, Donor lymphocytes, Tapering of immune suppression - Myelodysplastic Syndromes, Acute Myeloid Leukemia With Myelodysplasia Related Disease and < 30% Blasts | Phase 2 | Recruiting | Karolinska University Hospital | 200 | 2022-11-22 | 2023-12-05 |
| Guadecitabine and Donor Lymphocyte Infusion in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapsing After Allogeneic Stem Cell Transplant Donor Lymphocytes, Guadecitabine, Laboratory Biomarker Analysis - Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia | Phase 2 | Completed | M.D. Anderson Cancer Center | 55 | 2016-06-22 | 2025-11-06 |
| AML Therapy With Irradiated Allogeneic Cells fludarabine phosphate, cytarabine, donor lymphocytes - Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0) | Not applicable | Terminated | Rutgers, The State University of New Jersey | 6 | 2014-02-01 | 2021-08-24 |
| Donor Stem Cell Transplant in Treating Patients With Relapsed Hematologic Malignancies or Secondary Myelodysplasia Previously Treated With High-Dose Chemotherapy and Autologous Stem Cell Transplant anti-thymocyte globulin, donor lymphocytes, filgrastim - Leukemia, Lymphoma | Phase 2 | Terminated | Alliance for Clinical Trials in Oncology | 6 | 2010-12-01 | 2017-03-24 |
| Carmustine, Etoposide, Cytarabine, Melphalan, and Alemtuzumab Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed or Refractory Hodgkin Lymphoma alemtuzumab, donor lymphocytes, carmustine - Lymphoma | Phase 2 | Unknown | Cancer Research UK | 47 | 2009-07-01 | 2013-08-02 |
| Fludarabine Phosphate, Melphalan, and Alemtuzumab Followed by Donor Stem Cell Transplant in Treating Patients With Relapsed Hodgkin Lymphoma alemtuzumab, donor lymphocytes, cyclosporine - Lymphoma | Phase 2 | Unknown | Cancer Research UK | 49 | 2009-07-01 | 2013-08-02 |
| Donor Stem Cell Transplant in Treating Patients With Mantle Cell Lymphoma alemtuzumab, donor lymphocytes, carmustine - Lymphoma | Phase 2 | Unknown | Cancer Research UK | 25 | 2008-11-01 | 2013-08-02 |
| Wilm's Tumor 1 Protein Vaccine to Treat Cancers of the Blood WT1 Peptide-Pulsed Dendritic Cells, Donor Lymphocytes, IL-4 - Leukemia, Acute Myelogenous (AML), Leukemia, Acute Lymphocytic (ALL) | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 10 | 2008-02-22 | 2017-04-12 |
| Donor Lymphocyte Infusion in Treating Patients With Recurrent or Persistent Hematologic Cancer After Donor Stem Cell Transplant donor lymphocytes - Leukemia, Lymphoma | Not applicable | Completed | Roswell Park Cancer Institute | 39 | 2003-10-01 | 2020-08-26 |
| Reduced Intensity Donor Stem Cell Transplant in Treating Patients With High Risk Acute Lymphocytic Leukemia in Complete Remission nonmyeloablative allogeneic hematopoietic stem cell transplantation, donor lymphocytes, cyclosporine - Adult Acute Lymphoblastic Leukemia in Remission, Childhood Acute Lymphoblastic Leukemia in Remission | Phase 2 | Completed | Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium | 30 | 2001-09-01 | 2012-12-07 |
| Fludarabine and Cyclophosphamide Followed by Peripheral Stem Cell Transplant in Treating Patients With Leukemia or Lymphoma fludarabine phosphate, Cyclophosphamide, PBSC - Leukemia, Lymphoma | Phase 2 | Completed | Cancer and Leukemia Group B | 47 | 2001-02-01 | 2016-07-18 |
| Fludarabine Phosphate, Low-Dose Total-Body Irradiation, and Donor Stem Cell Transplant Followed by Cyclosporine, Mycophenolate Mofetil, Donor Lymphocyte Infusion in Treating Patients With Hematopoietic Cancer total-body irradiation, fludarabine phosphate, cyclosporine - Acute Undifferentiated Leukemia, Adult Nasal Type Extranodal NK/T-cell Lymphoma | Phase 1 / Phase 2 | Completed | Fred Hutchinson Cancer Center | 21 | 2000-05-01 | 2020-01-21 |
Hodgkin Disease (6) · Leukemia, Myeloid, Acute (6) · Lymphoma (6) · Lymphoma, Mantle-Cell (5) · Lymphoma, Non-Hodgkin (5) · Myelodysplastic Syndromes (5) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (5) · Leukemia (4) · Leukemia, Lymphocytic, Chronic, B-Cell (4) · Lymphoma, B-Cell, Marginal Zone (4) · Lymphoma, Follicular (4) · Burkitt Lymphoma (3) · Congenital Abnormalities (3) · Dendritic Cell Sarcoma, Interdigitating (3) · Leukemia, Myelomonocytic, Chronic (3)
Cancer Research UK (3) · Alliance for Clinical Trials in Oncology (1) · Cancer and Leukemia Group B (1) · Fred Hutchinson Cancer Center (1) · Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium (1) · Karolinska University Hospital (1) · M.D. Anderson Cancer Center (1) · National Cancer Institute (NCI) (1) · Roswell Park Cancer Institute (1) · Rutgers, The State University of New Jersey (1)
United States (8) · Italy (1) · Sweden (1)
Karl Peggs, MD (2) · Asad Bashey, MD, PhD (1) · Betul Oran, MD (1) · David Maloney (1) · George Georges (1) · Magnus Tobiasson, PhD (1) · Philip L. McCarthy, MD (1) · Roger Strair, MD, PhD (1) · Simon Rule, MD (1) · Terry J Fry, M.D. (1) · Thomas Shea, MD (1)
PMID 32499241, PMID 21296675, PMID 31869413
P01CA018029 (1), P01CA078902 (1), P30CA015704 (1), P30CA072720 (1), U10CA031946 (1)