5 unknown, 4 terminated, 3 completed. 12 Phase 1, 8 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 12 | Unknown 5, Terminated 4, Completed 3 |
| Phase 2 | 8 | Terminated 3, Unknown 3, Completed 2 |
Follow donafenib: new trials by email Literature Review of donafenib trials Research Report on donafenib
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of ZG005 Combined With Donafenib in Patients With Advanced Solid Tumor ZG005 Powder for Injection, Donafenib Tosilate Tablets - Solid Tumor | Phase 1 / Phase 2 | Unknown | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 130 | 2024-05-10 | 2024-06-14 |
| GEMOX Combined With Donafenib and Tislelizumab in Biliary Tract Cancer Combination of Gemcitabine, Oxaliplatin, Donafenib and Tislelizumab - Biliary Tract Carcinoma | Phase 1 / Phase 2 | Unknown | Fudan University | 10 | 2020-12-01 | 2021-08-09 |
| A Study of CS1001 in Combination With Donafenib in Subjects With Advanced Solid Tumors Donafenib, CS1001 - Advanced Solid Tumor | Phase 1 | Unknown | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 30 | 2020-10-15 | 2022-11-29 |
| Toripalimab Combined With Donafenib in the Treatment of Advanced Hepatocellular Carcinoma Donafenib Tosilate Tablets, Toripalimab Injection - Advanced Hepatocellular Carcinoma | Phase 1 / Phase 2 | Unknown | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 46 | 2020-10-15 | 2022-11-29 |
| Study on the Safety and Efficacy of Donafinib Combined With Anti-PD-1 Antibody as Adjuvant Therapy for HCC Patients Donafenib and anti-PD-1 antibody - Hepatocellular Carcinoma | Phase 1 | Completed | Zhejiang University | 30 | 2020-06-11 | 2026-02-17 |
| Treatment of Non-small Cell Lung Cancer With PD-1 Monoclonal Antibody Combined With Donafenib Toluene Sulfonate donafenib tablets - Non-small Cell Lung Cancer | Phase 1 | Unknown | First Affiliated Hospital of Zhejiang University | 20 | 2019-07-31 | 2019-08-16 |
| Combination of Donafenib and Cytarabine/Daunorubicin in Relapsed AML Donafenib - Acute Myeloid Leukemia (AML) | Phase 1 | Terminated | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 8 | 2018-11-06 | 2022-12-01 |
| Donafenib Monotherapy for Previously Treated Metastatic Nasopharyngeal Carcinoma Donafenib - Nasopharyngeal Carcinoma | Phase 1 / Phase 2 | Terminated | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 20 | 2017-02-08 | 2023-05-08 |
| Donafenib Monotherapy for Previously Treated Metastatic Gastric Cancer donafenib tosilate tablets - Gastric Cancer | Phase 1 / Phase 2 | Terminated | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 13 | 2016-05-16 | 2023-05-08 |
| A Study of Donafenib Monotherapy in Advanced Oesophageal Cancer donafenib tosilate tablets - Oesophageal Cancer | Phase 1 / Phase 2 | Terminated | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 19 | 2015-07-21 | 2023-06-15 |
| Safety and Efficacy of Donafenib in Patients With Advanced Hepatocellular Carcinoma Donafenib(200mg), Donafenib(300mg) - HCC | Phase 1 / Phase 2 | Completed | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 106 | 2014-04-01 | 2019-03-22 |
| Donafenib Monotherapy for Previously Treated Metastatic Colorectal Cancer CM4307 - Metastatic Colorectal Cancer | Phase 1 / Phase 2 | Completed | Suzhou Zelgen Biopharmaceuticals Co.,Ltd | 47 | 2014-03-01 | 2016-01-05 |
Carcinoma, Hepatocellular (1) · Carcinoma, Non-Small-Cell Lung (1) · Colorectal Neoplasms (1) · Esophageal Neoplasms (1) · Leukemia, Myeloid, Acute (1) · Nasopharyngeal Carcinoma (1) · Stomach Neoplasms (1)
Suzhou Zelgen Biopharmaceuticals Co.,Ltd (9) · First Affiliated Hospital of Zhejiang University (1) · Fudan University (1) · Zhejiang University (1)
China (12)
Feng Bi, Doctor (2) · Bao Rui, Doctor (1) · Jason Wu (1) · Jianming Xu, Doctor (1) · Jianxiang Wang, Doctor (1) · Jianying Zhou, MD (1) · Lu Wang, M.D. (1) · Shukui Qin, PhD (1) · Ye Guo, MD (1) · Yuan Kai Shi, Doctor (1)