17 completed, 2 unknown, 1 withdrawn. 7 Phase 4, 5 Phase 2, 3 Early Phase 1, 3 Phase 1, 2 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 7 | Completed 6, Unknown 1 |
| Phase 2 | 5 | Completed 4, Unknown 1 |
| Early Phase 1 | 3 | Completed 3 |
| Phase 1 | 3 | Completed 2, Withdrawn 1 |
| Not applicable | 2 | Completed 2 |
Follow DMPA: new trials by email Literature Review of DMPA trials Research Report on DMPA
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Measuring Lactation Initiation After Early Postpartum Injectable Progestin (DMPA) Use Among Women in Dhanusha District of Nepal: A Pilot Study Depo Medroxyprogesterone acetate - Postpartum Contraception, Depot Medroxyprogesterone Acetate | Phase 4 | Completed | University of California, San Diego | 40 | 2025-03-26 | 2025-09-10 |
| Endometrial Biopsy in Progestin Contraceptive Users DMPA, Etonogestrel implant - Contraception | Early Phase 1 | Completed | Oregon Health and Science University | 59 | 2023-07-01 | 2026-10-14 |
| BONE: STAR (Switching to TAF Based Anti-Retroviral Therapy) Study B/F/TAF, TDF/3TC/EFV or DTG or NVP, DMPA - Bone Loss | Phase 4 | Unknown | MU-JHU CARE | 330 | 2019-12-03 | 2023-04-07 |
| The Kampala Women's Bone Study FTC/TDF and DMPA, FTC/TDF, DMPA - Bone Demineralization, Hypoestrogenism | Phase 4 | Completed | University of Washington | 500 | 2018-05-15 | 2024-06-17 |
| Clinical Study of Depo Provera Comparing Lay Health Workers and Clinically-trained Health Workers DMPA, Sayana Press - Contraception | Early Phase 1 | Completed | FHI 360 | 460 | 2018-03-19 | 2021-04-13 |
| Pharmacokinetics and Pharmacodynamics of DMPA With HIV PrEP tenofovir/emtricitabine, DMPA - HIV/AIDS, Contraception | Early Phase 1 | Completed | Sharon Achilles | 15 | 2017-11-17 | 2020-12-03 |
| The Evidence for Contraceptive Options and HIV Outcomes Trial DMPA, LNG, Copper IUD - HIV, Contraception | Not applicable | Completed | FHI 360 | 7830 | 2015-12-14 | 2019-08-20 |
| PK Study of Rifampicin Interactions With DMPA and Efavirenz in TB Depot medroxyprogesterone acetate - HIV-1 Infection, Tuberculosis | Phase 2 | Completed | Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections | 62 | 2015-11-03 | 2019-07-01 |
| Effectiveness of Levonorgestrel-intrauterine System (LNG-IUS) Versus Depot Medroxyprogesterone Acetate (DMPA) in Treatment of Pelvic Pain in Clinically Diagnosed Endometriotic Patients LNG-IUS, DMPA - Endometriosis | Phase 4 | Completed | King Chulalongkorn Memorial Hospital | 50 | 2015-06-01 | 2017-03-17 |
| The Effect of Neoadjuvant DMPA on Glandular Cellularity in Women Awaiting Hysterectomy Depot medroxyprogesterone acetate, Placebo - Grade 1 Endometrial Endometrioid Adenocarcinoma, Grade 2 Endometrial Endometrioid Adenocarcinoma | Phase 2 | Unknown | Women and Infants Hospital of Rhode Island | 76 | 2015-02-01 | 2016-09-20 |
| Clinical Trial on the Effects of Progestin-based Contraception in the Genital Tract of HIV-infected and Uninfected Women Depo-Medroxyprogesterone Acetate, Progestin Contraceptive (Jadelle) - HIV, Contraception | Phase 4 | Completed | Centers for Disease Control and Prevention | 131 | 2014-04-08 | 2018-03-19 |
| HIV-Target Cell Response in Women Initiating Various Contraceptive Methods in High HIV-Incidence Areas: Zim CHIC DMPA, NET-EN, MPA/E2 - Contraception, HIV | Completed | University of Pittsburgh | 451 | 2014-02-01 | 2020-12-03 | |
| Long-Acting Reversible Contraception DMPA, oral contraceptives, Implanon® - Contraception | Phase 4 | Completed | FHI 360 | 916 | 2011-12-01 | 2018-02-28 |
| Timing of Postpartum Depot Medroxyprogesterone Acetate Administration on Breastfeeding, Contraceptive Continuation, and Depression Depot medroxyprogesterone acetate - Contraception, Postpartum Depression | Phase 4 | Completed | Beatrice Chen | 184 | 2011-11-01 | 2018-08-31 |
| Pharmacokinetic Interactions Between DMPA and LPV/r Among HIV-Infected Women depo-medroxyprogesterone acetate - HIV-1 Infection | Phase 2 | Completed | Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections | 25 | 2011-05-01 | 2015-12-22 |
| Same-day Long-acting Reversible Contraception for Medication Abortion DMPA, Etonogestrel implant - Abortion; Induced | Completed | Boston University | 40 | 2011-05-01 | 2017-04-07 | |
| Depot Contraception With and Without Lopinavir/Ritonavir DMPA - HIV Infection | Phase 1 | Withdrawn | St Stephens Aids Trust | 10 | 2010-12-01 | 2010-11-29 |
| Randomized Control Trial Copper Intrauterine Device and Depo-medroxyprogesterone Acetate (DMPA) of HIV+ Women in Malawi Copper IUD, Depo Medroxyprogesterone acetate - HIV | Not applicable | Completed | Emory University | 200 | 2010-07-01 | 2013-10-25 |
| Manipulation of the Intratesticular Hormonal Milieu With Exogenous Testosterone (HOP 5) Testicular Aspiration Addendum Acyline, Testosterone Gel, Depo-Medroxyprogesterone - Contraception | Phase 1 / Phase 2 | Completed | University of Washington | 23 | 2004-12-01 | 2008-09-19 |
| Male Hormonal Contraceptive Development-ACY-5 Acyline, Testosterone Gel, Depo-Medroxyprogesterone - Contraception | Phase 1 / Phase 2 | Completed | University of Washington | 43 | 2004-05-01 | 2008-09-19 |
Breast Feeding (2) · HIV Infections (2) · Acquired Immunodeficiency Syndrome (1) · Bone Demineralization, Pathologic (1) · Bone Diseases, Metabolic (1) · Depression, Postpartum (1) · Endometriosis (1) · Tuberculosis (1)
FHI 360 (3) · University of Washington (3) · Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections (2) · Beatrice Chen (1) · Boston University (1) · Centers for Disease Control and Prevention (1) · Emory University (1) · King Chulalongkorn Memorial Hospital (1) · MU-JHU CARE (1) · Oregon Health and Science University (1) · Sharon Achilles (1) · St Stephens Aids Trust (1) · University of California, San Diego (1) · University of Pittsburgh (1) · Women and Infants Hospital of Rhode Island (1)
United States (9) · Kenya (2) · Malawi (2) · South Africa (2) · Uganda (2) · Zimbabwe (2) · Botswana (1) · Eswatini (1) · Nepal (1) · Pakistan (1) · Puerto Rico (1) · Thailand (1) · United Kingdom (1) · Zambia (1)
Alison Edelman, MD (1) · Amneris E Luque, M.D. (1) · Athena P Kourtis, MD, PhD, MPH (1) · David Hubacher, PhD (1) · Dawn S Chin-Quee, PhD, MPH (1) · Felix Mhlanga, MD (1) · Flavia Kiweewa Matovu, MBChB, MSc (1) · Jennifer Robinson, MD, MPH (1) · Jennifer Tang, MD, MSCR (1) · Jessica Tarleton, MD, MPH (1) · Lameck Chinula, MD (1) · Lisa Haddad, MD (1) · Renee Heffron, PhD, MPH (1) · Rosie Mngqibisa, MBChB, MPH (1) · Sam Phiri, PhD (1)
PMID 17494097, PMID 16940442, PMID 17303493, PMID 24028749, PMID 25481376, PMID 25624326, PMID 29470950, PMID 29746813, PMID 29920171, PMID 31204114, PMID 31374188, PMID 31504342, PMID 32396700, PMID 32533883, PMID 33898953, PMID 34126052, PMID 34369424, PMID 34910143, PMID 35263421, PMID 35657948, PMID 35669313, PMID 35941737, PMID 35972853, PMID 36622252, PMID 36892945, PMID 38459552, PMID 39085989, PMID 39630076
U54HD042454 (2), K01TW009657 (1), R01HD089843 (1), U01AI068636 (1), U48DP001944 (1), UM1AI068636 (1)