3 recruiting, 1 active not recruiting, 1 completed, 1 terminated. 7 Phase 2, 2 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Recruiting 3, Active not recruiting 1, Completed 1, Terminated 1, Unknown 1 |
| Phase 3 | 2 | Recruiting 2 |
Follow Circulating Tumor DNA: new trials by email Literature Review of Circulating Tumor DNA trials Research Report on Circulating Tumor DNA
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| NEO-BLAST: Neoadjuvant Therapy for Bladder Cancer Followed by Active Surveillance vs Treatment Active Surveillance, Control arm - Definitive bladder treatment - Muscle-Invasive Bladder Carcinoma | Phase 2 / Phase 3 | Recruiting | Peter Black | 688 | 2025-07-28 | 2025-07-30 |
| Testing the Role of DNA Released From Tumor Cells Into the Blood in Guiding the Use of Immunotherapy After Surgical Removal of the Bladder, Kidney, Ureter, and Urethra for Urothelial Cancer Treatment, MODERN Study Biospecimen Collection, cfDNA or ctDNA Measurement, Computed Tomography - Muscle Invasive Bladder Urothelial Carcinoma, Muscle Invasive Renal Pelvis Urothelial Carcinoma | Phase 2 / Phase 3 | Recruiting | National Cancer Institute (NCI) | 992 | 2024-02-02 | 2026-11-02 |
| Circulating Tumor DNA-guided Neoadjuvant Treatment Strategy for Locally Advanced Rectal Cancer circulating tumor DNA - Locally Advanced Rectal Carcinoma, Circulating Tumor DNA | Phase 2 | Recruiting | Peking Union Medical College Hospital | 470 | 2023-02-03 | 2024-12-24 |
| A Study of Local Ablative Therapy (LAT) in People With Non-Small Cell Lung Cancer (NSCLC) Local ablative therapy, Blood collection to assess for ctDNA - Non-small Cell Lung Cancer, Metastatic Non Small Cell Lung Cancer | Phase 2 | Completed | Memorial Sloan Kettering Cancer Center | 37 | 2022-06-15 | 2026-02-02 |
| Swallowing Outcomes and Circulating Tumor DNA in Patients With HPV Related Oropharyngeal Cancer Treated With Transoral Surgery and Reduced Intensity Adjuvant Therapy Transoral Surgery, External Beam Radiation Therapy, Cisplatin - Clinical Stage I HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8, Clinical Stage II HPV-Mediated (p16-Positive) Oropharyngeal Carcinoma AJCC v8 | Phase 2 | Active not recruiting | Rutgers, The State University of New Jersey | 15 | 2021-05-19 | 2026-08-14 |
| Study of Binimetinib With Encorafenib in Adults With Recurrent BRAF V600-Mutated HGG Encorafenib, Binimetinib, Research Bloods - High Grade Glioma, BRAF V600E | Phase 2 | Terminated | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 5 | 2019-07-29 | 2024-10-31 |
| Liquid Biopsy in Monitoring the Neoadjuvant Chemotherapy and Operation in Gastric Cancer Neoadjuvant chemotherapy with PSOX regimen., Detect the imaging data and levels of CTC, ctDNA, cfDNA, CEA, CA19-9, CA72-4 in plasma., Detect the tumor related DNA in pathological tissues after operation. - Gastric Cancer, Gastro-oesophageal Junction Cancer | Phase 2 | Unknown | Affiliated Hospital of Qinghai University | 40 | 2019-05-28 | 2020-01-22 |
Astrocytoma (1) · Carcinoma, Non-Small-Cell Lung (1) · Glioblastoma (1) · Glioma (1) · Gliosarcoma (1) · Neoplasm, Residual (1) · Neoplastic Cells, Circulating (1) · Oropharyngeal Neoplasms (1) · Stomach Neoplasms (1) · Urinary Bladder Neoplasms (1)
Affiliated Hospital of Qinghai University (1) · Memorial Sloan Kettering Cancer Center (1) · National Cancer Institute (NCI) (1) · Peking Union Medical College Hospital (1) · Peter Black (1) · Rutgers, The State University of New Jersey (1) · Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins (1)
United States (4) · Canada (2) · China (2)
Daniel Gomez, MD (1) · Karisa C Schreck, MD (1) · Matin Imanguli, MD, DDS (1) · Matthew D Galsky (1) · Peter Black, MD (1) · Stuart A Grossman, MD (1)
PMID 39894522, PMID 41435753, PMID 42567733
P30CA072720 (1), U10CA180821 (1), UM1CA137443 (1)