3 recruiting, 1 active not recruiting, 1 not yet recruiting. 4 Phase 2, 3 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Recruiting 2, Active not recruiting 1, Not yet recruiting 1 |
| Phase 1 | 3 | Recruiting 3 |
Follow Unresectable Skin Squamous Cell Carcinoma: new trials by email Literature Review of Unresectable Skin Squamous Cell Carcinoma trials Research Report on Unresectable Skin Squamous Cell Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO Trial Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 | Phase 2 | Not yet recruiting | Fred Hutchinson Cancer Center | 50 | 2026-12-01 | 2026-09-17 |
| Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 16 | 2024-07-24 | 2026-10-14 |
| Radiotherapy in Combination With Atezolizumab in Locally Advanced Borderline Resectable or Unresectable Cutaneous SCC Atezolizumab, Stereotactic Body Radiation Therapy - Locally Advanced Skin Squamous Cell Carcinoma, Resectable Skin Squamous Cell Carcinoma | Phase 1 | Recruiting | City of Hope Medical Center | 12 | 2022-04-19 | 2026-01-28 |
| Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors Cyclophosphamide, Neoantigen Peptide Vaccine, Pembrolizumab - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 138 | 2022-03-31 | 2026-08-20 |
| Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic Laboratory Biomarker Analysis, Pembrolizumab, Questionnaire Administration - Advanced Malignant Solid Neoplasm, Carcinoma of Unknown Primary | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 157 | 2016-08-15 | 2026-07-17 |
Carcinoma, Merkel Cell (3) · Carcinoma, Renal Cell (3) · Melanoma (3) · Neoplasm Metastasis (3) · Carcinoma, Basal Cell (2) · Carcinoma, Non-Small-Cell Lung (2) · Carcinoma, Transitional Cell (2) · Lung Neoplasms (2) · Squamous Cell Carcinoma of Head and Neck (2) · Uterine Cervical Neoplasms (2) · Adrenal Cortex Neoplasms (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Lobular (1) · Carcinoma, Small Cell (1) · Carcinosarcoma (1)
Adenocarcinoma (4) · Carcinoma (4) · Neoplasms (4) · Neoplasms by Histologic Type (4) · Neoplasms by Site (4) · Neoplasms, Germ Cell and Embryonal (4) · Neoplasms, Glandular and Epithelial (4) · Neoplasms, Nerve Tissue (4) · Neuroectodermal Tumors (4) · Neuroendocrine Tumors (4) · Carcinoma, Neuroendocrine (3) · DNA Virus Infections (3) · Female Urogenital Diseases (3) · Female Urogenital Diseases and Pregnancy Complications (3) · Genital Diseases (3)
Magnetic Resonance Spectroscopy (3) · Specimen Handling (3) · Biopsy (2) · Nivolumab (2) · pembrolizumab (2) · CTLA-4 Antigen (1) · Colony-Stimulating Factors (1) · Cyclophosphamide (1) · Immunoglobulin G (1) · Ipilimumab (1) · Prednisone (1) · Radiosurgery (1) · Sirolimus (1) · X-Rays (1) · atezolizumab (1)
City of Hope Medical Center (1) · Fred Hutchinson Cancer Center (1) · M.D. Anderson Cancer Center (1) · Mayo Clinic (1) · National Cancer Institute (NCI) (1)
United States (4) · Uganda (1)
Arya Amini (1) · Aung Naing (1) · Evan J Lipson (1) · Shailender Bhatia, MD (1) · Yanyan Lou, MD, PhD (1)
PMID 31533818, PMID 32188704, PMID 32303619, PMID 32534809, PMID 33415580, PMID 33427689, PMID 33491277, PMID 33770291, PMID 34241781, PMID 34725215, PMID 35618285, PMID 35999229, PMID 37568622, PMID 40212844, PMID 41143139, PMID 42342409
P30CA033572 (1), UM1CA186691 (1)