4 terminated, 1 recruiting. 4 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Terminated 3, Recruiting 1 |
| Phase 2 | 1 | Terminated 1 |
Follow RAF Mutation: new trials by email Literature Review of RAF Mutation trials Research Report on RAF Mutation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of DCC-3084 in Participants With Advanced Malignancies Driven by the Mitogen-Activated Protein Kinase (MAPK) Pathway DCC-3084 - Advanced Solid Tumor, RAF Mutation | Phase 1 | Terminated | Deciphera Pharmaceuticals, LLC | 29 | 2024-05-14 | 2026-03-05 |
| PAS-004 in Patients With Advanced Solid Tumors PAS-004 Capsules, PAS-004 Tablets - RAS Mutation, NF1 Mutation | Phase 1 | Recruiting | Pasithea Therapeutics Corp. | 83 | 2024-02-29 | 2026-10-30 |
| Safety and Effectiveness of ABM-168 in Adults with Advanced Solid Tumors. ABM-168 - Advanced Solid Tumor, RAS Mutation | Phase 1 | Terminated | ABM Therapeutics Corporation | 12 | 2023-03-30 | 2024-12-06 |
| Tovorafenib (DAY101) or in Combination With Pimasertib for Participants With Melanoma and Other Solid Tumors Tovorafenib, Tovorafenib Drug: Pimasertib - Melanoma, Solid Tumor | Phase 1 | Terminated | Day One Biopharmaceuticals, Inc. | 44 | 2022-05-02 | 2025-08-14 |
| Tovorafenib (DAY101) Monotherapy for Patients With Melanoma and Other Solid Tumors Tovorafenib - Melanoma, Solid Tumor | Phase 2 | Terminated | Day One Biopharmaceuticals, Inc. | 23 | 2021-07-15 | 2025-10-02 |
Melanoma (4) · Carcinoma, Non-Small-Cell Lung (3) · Colorectal Neoplasms (3) · Pancreatic Neoplasms (3) · Astrocytoma (2) · Brain Neoplasms (1) · Glioblastoma (1) · Lung Neoplasms (1) · Neoplasms (1) · Thyroid Cancer, Papillary (1) · Urinary Bladder Neoplasms (1)
Lung Diseases (4) · Neoplasms (4) · Neoplasms by Histologic Type (4) · Neoplasms by Site (4) · Neoplasms, Germ Cell and Embryonal (4) · Neoplasms, Nerve Tissue (4) · Neuroectodermal Tumors (4) · Neuroendocrine Tumors (4) · Nevi and Melanomas (4) · Respiratory Tract Diseases (4) · Respiratory Tract Neoplasms (4) · Skin Diseases (4) · Skin Neoplasms (4) · Skin and Connective Tissue Diseases (4) · Thoracic Neoplasms (4)
tovorafenib (2)
Day One Biopharmaceuticals, Inc. (2) · ABM Therapeutics Corporation (1) · Deciphera Pharmaceuticals, LLC (1) · Pasithea Therapeutics Corp. (1)
United States (5) · Canada (2) · Australia (1) · Belgium (1) · Bulgaria (1) · France (1) · Romania (1) · South Korea (1) · Spain (1)