11 completed. 11 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 11 | Completed 11 |
Follow Mantle Cell Lymphoma: new trials by email Literature Review of Mantle Cell Lymphoma trials Research Report on Mantle Cell Lymphoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| R-CHOP + R-HAD vs R-CHOP Followed by Maintenance Lenalidomide + Rituximab vs Rituximab for Older Patients With MCL R-CHOP, R-CHOP / R-HAD, Rituximab - Mantle Cell Lymphoma | Phase 3 | Completed | The Lymphoma Academic Research Organisation | 623 | 2013-11-01 | 2025-03-05 |
| A Study of the Bruton's Tyrosine Kinase Inhibitor Ibrutinib Given in Combination With Bendamustine and Rituximab in Patients With Newly Diagnosed Mantle Cell Lymphoma Bendamustine, Rituximab, Ibrutinib - Mantle Cell Lymphoma | Phase 3 | Completed | Janssen Research & Development, LLC | 523 | 2013-05-16 | 2025-07-08 |
| Study of Ibrutinib (a Bruton's Tyrosine Kinase Inhibitor), Versus Temsirolimus in Patients With Relapsed or Refractory Mantle Cell Lymphoma Who Have Received at Least One Prior Therapy Ibrutinib, Temsirolimus - Mantle Cell Lymphoma | Phase 3 | Completed | Janssen Research & Development, LLC | 280 | 2012-12-10 | 2018-01-19 |
| Double Cord Versus Haploidentical (BMT CTN 1101) Haploidentical Bone Marrow Transplant, Double Umbilical Cord Blood Transplant - Acute Lymphocytic Leukemia, Acute Myelogenous Leukemia | Phase 3 | Completed | Medical College of Wisconsin | 368 | 2012-06-01 | 2021-12-01 |
| Graft-Versus-Host Disease Prophylaxis in Treating Patients With Hematologic Malignancies Undergoing Unrelated Donor Peripheral Blood Stem Cell Transplant Allogeneic Hematopoietic Stem Cell Transplantation, Cyclosporine, Fludarabine Phosphate - Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia | Phase 3 | Completed | Fred Hutchinson Cancer Center | 174 | 2010-11-01 | 2026-04-30 |
| Study to Assess the Effect of Treatment With Bendamustine in Combination With Rituximab on QT Interval in Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL) Bendamustine, Rituximab - Non-Hodgkin's Lymphoma, Mantle Cell Lymphoma | Phase 3 | Completed | Cephalon | 54 | 2010-02-01 | 2014-04-24 |
| Study of Bendamustine Hydrochloride and Rituximab (BR) Compared With R-CVP or R-CHOP in the First-Line Treatment of Patients With Advanced Indolent Non-Hodgkin's Lymphoma (NHL) or Mantle Cell Lymphoma (MCL) - Referred to as the BRIGHT Study bendamustine, rituximab, vincristine - Non-Hodgkin's Lymphoma, Mantle Cell Lymphoma | Phase 3 | Completed | Teva Branded Pharmaceutical Products R&D, Inc. | 447 | 2009-04-30 | 2018-02-05 |
| Mantel Cell Lymphoma Efficacy of Rituximab Maintenance Rituximab, Watch and wait - Mantle Cell Lymphoma | Phase 3 | Completed | French Innovative Leukemia Organisation | 299 | 2008-09-01 | 2018-04-27 |
| Study of the Combination of Rituximab, Cyclophosphamide, Doxorubicin, VELCADE, and Prednisone or Rituximab, Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone in Patients With Newly Diagnosed Mantle Cell Lymphoma Rituximab 375 mg/m^2, Cyclophosphamide 750 mg/m^2, Doxorubicin 50 mg/m^2 - Mantle Cell Lymphoma | Phase 3 | Completed | Millennium Pharmaceuticals, Inc. | 487 | 2008-05-01 | 2018-07-12 |
| Total-Body Irradiation With or Without Fludarabine Phosphate Followed By Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer Total-Body Irradiation, Fludarabine Phosphate, Mycophenolate Mofetil - Acute Lymphoblastic Leukemia in Remission, Acute Myeloid Leukemia in Remission | Phase 3 | Completed | Fred Hutchinson Cancer Center | 87 | 2003-10-01 | 2017-05-15 |
| Bendamustine Plus Rituximab Versus Fludarabine Plus Rituximab Bendamustine plus Rituximab, Fludarabine 25 mg/m² d 1-3 + Rituximab 375 mg/m² d 1 q4w - Non-Hodgkin's Lymphoma, Mantle Cell Lymphoma | Phase 3 | Completed | University of Giessen | 230 | 2003-09-01 | 2024-08-22 |
Lymphoma, Mantle-Cell (11) · Lymphoma, Non-Hodgkin (4) · Hodgkin Disease (3) · Hematologic Neoplasms (2) · Leukemia, Lymphocytic, Chronic, B-Cell (2) · Leukemia, Myeloid, Acute (2) · Lymphoma, Large B-Cell, Diffuse (2) · Multiple Myeloma (2) · Precursor Cell Lymphoblastic Leukemia-Lymphoma (2) · Waldenstrom Macroglobulinemia (2) · Burkitt Lymphoma (1) · Leukemia (1) · Leukemia, Myelogenous, Chronic, BCR-ABL Positive (1) · Leukemia, Myeloid, Chronic-Phase (1) · Leukemia, Prolymphocytic (1)
Hemic and Lymphatic Diseases (11) · Immune System Diseases (11) · Immunoproliferative Disorders (11) · Lymphatic Diseases (11) · Lymphoproliferative Disorders (11) · Neoplasms (11) · Neoplasms by Histologic Type (11) · Lymphoma (10) · Lymphoma, Non-Hodgkin (7) · Hematologic Diseases (3) · Leukemia, Lymphoid (3) · Leukemia, Myeloid (3) · Lymphoma, B-Cell (3) · Blood Protein Disorders (2) · Bone Marrow Diseases (2)
Rituximab (7) · Bendamustine Hydrochloride (4) · Cyclophosphamide (2) · Cyclosporine (2) · Cyclosporins (2) · Doxorubicin (2) · Mycophenolic Acid (2) · Peripheral Blood Stem Cell Transplantation (2) · Prednisone (2) · Vincristine (2) · Whole-Body Irradiation (2) · fludarabine phosphate (2) · ibrutinib (2) · Bortezomib (1) · Lenalidomide (1)
Fred Hutchinson Cancer Center (2) · Janssen Research & Development, LLC (2) · Cephalon (1) · French Innovative Leukemia Organisation (1) · Medical College of Wisconsin (1) · Millennium Pharmaceuticals, Inc. (1) · Teva Branded Pharmaceutical Products R&D, Inc. (1) · The Lymphoma Academic Research Organisation (1) · University of Giessen (1)
Germany (7) · United States (7) · Canada (5) · Belgium (4) · Brazil (4) · France (4) · Poland (4) · Spain (4) · Australia (3) · Czechia (3) · Hungary (3) · Mexico (3) · Netherlands (3) · Portugal (3) · Russia (3)
Brenda Sandmaier (2) · Johanna Cornelia Kluin-Nelemans, Prof. Dr. (1) · Martin Dreyling, Prof. Dr. (1) · Mary Horowitz, MD, MS (1) · Vincent Ribrag, Dr (1)
PMID 32499241, PMID 24591201, PMID 25738670, PMID 26673811, PMID 26875824, PMID 28183846, PMID 28583031, PMID 28751558, PMID 28953447, PMID 30348538, PMID 30811293, PMID 31248843, PMID 33475736, PMID 34273598, PMID 35657079, PMID 37088401, PMID 37120135, PMID 38669626, PMID 39846144, PMID 41350757
P30CA015704 (2), P01CA018029 (1), P01CA078902 (1), U10HL069294 (1), U24CA076518 (1)