13 recruiting, 10 completed, 3 active not recruiting, 2 not yet recruiting. 15 Not applicable, 9 Phase 2, 4 Phase 3, 2 Phase 1.
Follow Localized Prostate Cancer: new trials by email Literature Review of Localized Prostate Cancer trials Research Report on Localized Prostate Cancer
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 68Ga-PSMA-11 PET/MRI for Selecting Men With Prostate Cancer for Focal Therapy Gallium Ga 68 Gozetotide (68Ga-PSMA-11), Intervention Description: Integrated positron emission tomography/magnetic resonance imaging (PET/MRI) combines molecular imaging with high-resolution anatomical MRI to evaluate intraprostatic lesions - Prostate Cancer (Adenocarcinoma), Localized Prostate Cancer | Not applicable | Not yet recruiting | University Health Network, Toronto | 8 | 2026-09-01 | 2026-08-05 |
| WATER IV PCa (AS Sub-study) Aquablation Therapy, Active Surveillance - Localized Prostate Cancer | Not applicable | Not yet recruiting | PROCEPT BioRobotics | 333 | 2026-09-01 | 2026-11-02 |
| SPECTRA: Intraoperative Hyperspectral Imaging for Prostate Cancer HyperSpectral imaging acquisition of ex-vivo prostate specimen prior formalin fixation (fresh acquisition).. - Localized Prostate Cancer, Positive Surgical Margin | Not applicable | Recruiting | Massimo Valerio | 26 | 2026-08-01 | 2026-09-17 |
| PRO-BOOST-LC: Whole-Gland Boost Strategies Versus SBRT Monotherapy in PSMA-Staged Localized and Locally Advanced Prostate Cancer Stereotactic Body Radiotherapy (SBRT) Monotherapy, External Beam Radiotherapy (EBRT) Backbone, High-Dose-Rate Brachytherapy Boost - Prostate Cancer (Adenocarcinoma), Prostate Brachytherapy | Phase 2 / Phase 3 | Recruiting | Affidea Nu-med Center of Oncological DIagnostics and Therapy | 1000 | 2026-03-19 | 2026-07-21 |
| Oxybutynin ER to Promote Early Continence Recovery After Robotic Prostatectomy: A Randomized Controlled Trial Oxybutynin chloride extended-release tablets 5mg/tab, 2 tab, PO, qd., Placebo (2 tab), PO, qd. - Localized Prostate Cancer, Postoperative Urinary Incontinence | Not applicable | Recruiting | National Taiwan University Hospital | 135 | 2025-09-15 | 2026-03-16 |
| Focal Micro-boost Strategy in Patients With Intermediate- to High-risk Prostate Cancer (IR-HR PCa) Undergoing Hypofractionated Radiotherapy Localized Prostate Cancer | Recruiting | Regina Elena Cancer Institute | 82 | 2025-08-07 | 2026-08-28 | |
| Is Adaptive SBRT for Prostate vs Image-guided Radiotherapy a True Evolution (ASPIRE) SBRT - Localized Prostate Cancer, Stereotactic Body Radiotherapy | Phase 3 | Recruiting | University Health Network, Toronto | 320 | 2025-02-04 | 2026-06-02 |
| WATER IV Prostate Cancer Aquablation Therapy, Radical Prostatectomy - Localized Prostate Cancer | Not applicable | Active not recruiting | PROCEPT BioRobotics | 280 | 2025-02-03 | 2026-05-04 |
| The PRECISION Study: 3 Fractions of Prostate SBRT and RayPilot HypoCath Image Guidance 3 fractions of prostate SBRT - Localized Prostate Cancer, Low Risk Prostate Cancer | Not applicable | Recruiting | NHS Lothian | 100 | 2024-11-01 | 2026-01-12 |
| Radical Hypofractionated Radiotherapy for Localized Prostate Cancer Hypofractionated radiation therapy - Localized Prostate Cancer | Not applicable | Recruiting | Changhai Hospital | 20 | 2024-09-01 | 2024-08-26 |
| Clinical Study of HIFU for Localized Prostate Cancer EQ-5D-5L IPSS IIEF-5 EPIC-26 ECOG - Localized Prostate Cancer | Recruiting | RenJi Hospital | 60 | 2024-05-21 | 2024-08-15 | |
| PRCT002 PRostate Cancer Treatment With the AQUABEAM Robotic System Robotic Waterjet Treatment - Localized Prostate Cancer | Not applicable | Unknown | PROCEPT BioRobotics | 22 | 2024-03-11 | 2024-08-14 |
| Hypofractionated Post-prostatectomy Radiotherapy (HYPORT)for Localized Prostate Cancer Conventional radiation therapy, Hypofractionated radiation therapy - Localized Prostate Cancer | Not applicable | Recruiting | Changhai Hospital | 428 | 2024-02-01 | 2024-08-26 |
| PRCT001 Aquablation theraPy Outcomes in pRostate Cancer patienTs Robotic Waterjet Treatment - Benign Prostatic Hyperplasia, Localized Prostate Cancer | Not applicable | Active not recruiting | PROCEPT BioRobotics | 125 | 2022-11-22 | 2026-01-28 |
| 18F-DCFPyL Imaging as a Method to Assess Treatment Response to Stereotactic Body Radiation Therapy 18F-DCFPyL - Localized Prostate Cancer | Phase 2 | Recruiting | National Cancer Institute (NCI) | 130 | 2022-08-31 | 2026-10-16 |
| Functional Image-Guided Carbon Ion Irradiation With Simultaneous Integrated Boost for Prostate Cancer carbon ion irradation, Carbon Ion Irradiation With SIB - Localized Prostate Cancer | Phase 2 | Recruiting | Shanghai Proton and Heavy Ion Center | 140 | 2020-10-15 | 2021-11-15 |
| Evaluation of Efficacy of TOOKAD® (VTP) Versus Active Surveillance for Intermediate Risk Localized Prostate Cancer TOOKAD® - Localized Prostate Cancer | Phase 3 | Withdrawn | Steba Biotech S.A. | 2020-03-31 | 2020-11-13 | |
| Neoadjuvant Atezolizumab-Based Combination Therapy in Men With Localized Prostate Cancer Prior to Radical Prostatectomy Atezolizumab, Tocilizumab, Etrumadenant - Prostate Adenocarcinoma, Prostate Cancer | Phase 2 | Recruiting | David Oh | 68 | 2019-10-30 | 2026-06-04 |
| MRI- Guided Transurethral Ultrasound Ablation of Localized Prostate Cancer Magnetic Resonance Imaging-Guided Transurethral Ultrasound Ablation of Prostate Tissue - MRI Guided Transurethral Ultrasound Ablation, Localized Prostate Cancer | Not applicable | Completed | University Hospital, Strasbourg, France | 25 | 2019-09-24 | 2026-01-08 |
| Prospective Clinical Safety and Efficacy Study of Lesion-targeted MRI-TULSA for Localized Prostate Cancer MRI-TULSA - Localized Prostate Cancer | Not applicable | Active not recruiting | Turku University Hospital | 62 | 2018-10-30 | 2025-09-22 |
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Prostatic Neoplasms (18) · Adenocarcinoma (2) · Lower Urinary Tract Symptoms (2) · Prostatic Hyperplasia (2) · Breast Neoplasms (1) · Carcinoma (1) · Fatigue (1) · Genital Diseases, Male (1) · Genital Neoplasms, Male (1) · Male Urogenital Diseases (1) · Margins of Excision (1) · Motor Activity (1) · Neoplasms (1) · Neoplasms by Site (1) · Prostatic Diseases (1)
Genital Diseases (18) · Urogenital Diseases (18) · Genital Diseases, Male (17) · Genital Neoplasms, Male (17) · Male Urogenital Diseases (17) · Neoplasms (17) · Neoplasms by Site (17) · Prostatic Diseases (17) · Urogenital Neoplasms (17) · Pathological Conditions, Signs and Symptoms (5) · Signs and Symptoms (4) · Neoplasms by Histologic Type (3) · Neoplasms, Glandular and Epithelial (3) · Urological Manifestations (3) · Carcinoma (2)
padeliporfin (2) · 2-(3-(1-carboxy-5-((6-fluoropyridine-3-carbonyl)amino)pentyl)ureido)pentanedioic acid (1) · Abiraterone Acetate (1) · Androgen Antagonists (1) · Blood Specimen Collection (1) · Clostridium perfringens epsilon-toxin (1) · Dutasteride (1) · Exercise (1) · Exercise Test (1) · Magnetic Resonance Imaging (1) · Positron-Emission Tomography (1) · Posterior Cruciate Ligament Reconstruction (1) · Prednisone (1) · Radiosurgery (1) · Tablets (1)
PROCEPT BioRobotics (4) · Changhai Hospital (2) · Steba Biotech S.A. (2) · University Health Network, Toronto (2) · Affidea Nu-med Center of Oncological DIagnostics and Therapy (1) · Arizona Oncology Services (1) · Baylor College of Medicine (1) · David Oh (1) · Georgetown University (1) · Hospices Civils de Lyon (1) · Institut Claudius Regaud (1) · Kenneth Pienta, MD (1) · Massimo Valerio (1) · Memorial Sloan Kettering Cancer Center (1) · Momotaro-Gene Inc. (1)
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Jonathan Coleman, MD (2) · Adriano Basso Dias, MD, MSc, Radiologist (1) · Brian J Miles, MD, FACS (1) · Christopher J Kane, MD (1) · Clint D. Bahler, MD, MS (1) · David M Latini, PhD (1) · David Oh, MD, PhD (1) · Deborah E Citrin, M.D. (1) · Duncan B McLaren, MBBS (1) · Emily Grade, MD (1) · Joseph Osborne, MD, PhD (1) · June Chan, Sc.D. (1) · Kathryn L. Taylor, Ph.D. (1) · Kenneth J Pienta, MD (1) · Massimo Valerio (1)
PMID 10647798, PMID 18308133, PMID 18338955, PMID 19013590, PMID 19814699, PMID 19930331, PMID 20970066, PMID 21791359, PMID 21860770, PMID 22749852, PMID 26850969, PMID 27626136, PMID 27626365, PMID 27720536, PMID 29510957, PMID 36348363, PMID 36711157, PMID 40257456, PMID 40441432
R01CA181802 (1)