13 completed. 13 Phase 3, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 13 | Completed 13 |
| Phase 2 | 5 | Completed 5 |
Follow Keratoconus: new trials by email Literature Review of Keratoconus trials Research Report on Keratoconus
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus Riboflavin and Sodium Iodide solution and Ultraviolet-A treatment, Placebo and sham treatment - Keratoconus | Phase 3 | Completed | Epion Therapeutics | 398 | 2023-11-01 | 2026-06-25 |
| Epithelium-On Corneal Cross-linking in Subjects 8 to 45 Years of Age With Keratoconus Riboflavin and Sodium Iodide solution and Ultraviolet-A treatment, Placebo and sham treatment - Keratoconus | Phase 3 | Completed | Epion Therapeutics | 396 | 2023-10-30 | 2026-06-25 |
| Comparison of Standard vs. Accelerated Corneal Crosslinking riboflavin 0.1%, Riboflavin 0.1% - Keratoconus, Ectasia Corneal | Phase 2 / Phase 3 | Completed | Price Vision Group | 508 | 2019-04-16 | 2026-09-17 |
| Endothelial Cell Loss After Penetrating Keratoplasty PKP - Keratoconus | Phase 2 / Phase 3 | Completed | Alexandria University | 8 | 2018-07-01 | 2020-07-07 |
| Accelerated Corneal Cross-linking With Different Riboflavin Solutions Riboflavin - Keratoconus | Phase 3 | Completed | Medical University of Vienna | 60 | 2016-09-19 | 2021-03-03 |
| Microwave Treatment and Corneal Collagen Crosslinking for Keratoconus riboflavin ophthalmic solution, Vedera KXS Microwave System - Keratoconus | Phase 3 | Completed | Cornea and Laser Eye Institute | 3 | 2012-08-01 | 2018-07-17 |
| Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus riboflavin solution, placebo solution, KXL System - Keratoconus | Phase 3 | Completed | Glaukos Corporation | 230 | 2012-07-01 | 2021-04-26 |
| Safety and Efficacy Study of Corneal Collagen Cross-Linking in Eyes With Keratoconus riboflavin solution, placebo solution, KXL System - Keratoconus | Phase 3 | Completed | Glaukos Corporation | 236 | 2012-07-01 | 2021-04-26 |
| Corneal Sensitivity Cross-linking Keratoconus Cochet-Bonnet esthesiometer central corneal sensitivity - Keratoconus | Phase 2 / Phase 3 | Completed | Instituto de Olhos de Goiania | 19 | 2009-03-01 | 2012-12-06 |
| Corneal Collagen Cross-Linking for the Treatment of Progressive Keratoconus and Corneal Ectasia Corneal collagen, Sham comparator - Progressive Keratoconus, Corneal Ectasia | Phase 2 / Phase 3 | Completed | Emory University | 160 | 2007-12-01 | 2010-09-02 |
| Corneal Collagen Cross-linking for Progressive Keratoconus riboflavin ophthalmic solution, UVA Irradiation - Progressive Keratoconus | Phase 3 | Completed | Glaukos Corporation | 147 | 2007-12-01 | 2021-04-26 |
| Riboflavin Mediated Corneal Crosslinking for Stabilizing Progression of Keratoconus Riboflavin/UVA crosslinking, Sham treatment - Keratoconus | Phase 2 / Phase 3 | Completed | University Hospital Freiburg | 30 | 2007-08-01 | 2013-01-17 |
| Deep Anterior Lamellar Keratoplasty (DALK) Deep anterior lamellar keratoplasty (DALK), Penetrated keratoplasty - Keratoconus | Phase 3 | Completed | Hospital Oftalmologico de Brasilia | 40 | 2006-01-01 | 2009-04-24 |
Corneal Diseases (2) · Dilatation, Pathologic (1)
Eye Diseases (13) · Corneal Diseases (11) · Pathological Conditions, Anatomical (1) · Pathological Conditions, Signs and Symptoms (1)
Riboflavin (3) · Corneal Cross-Linking (1)
Glaukos Corporation (3) · Epion Therapeutics (2) · Alexandria University (1) · Cornea and Laser Eye Institute (1) · Emory University (1) · Hospital Oftalmologico de Brasilia (1) · Instituto de Olhos de Goiania (1) · Medical University of Vienna (1) · Price Vision Group (1) · University Hospital Freiburg (1)
United States (8) · Brazil (2) · Austria (1) · Egypt (1) · Germany (1)
Michael Belin, MD (2) · Vineeta Belanger (2) · Belquiz A Nassaralla, MD PhD (1) · Ehab Mossallam, PhD (1) · Francis W Price, Jr., MD (1) · Peter Hersh, MD (1) · Peter S Hersh, MD (1) · Philip Maier, MD (1) · R. Doyle Stulting, MD, PhD (1)
PMID 17258522, PMID 17434435, PMID 17721317, PMID 22331118, PMID 22692521, PMID 25365551, PMID 26194634