12 completed, 2 unknown, 1 active not recruiting, 1 not yet recruiting. 8 Phase 4, 7 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 4 | 8 | Completed 5, Not yet recruiting 1, Recruiting 1, Unknown 1 |
| Phase 3 | 7 | Completed 5, Active not recruiting 1, Unknown 1 |
Follow Central Precocious Puberty: new trials by email Literature Review of Central Precocious Puberty trials Research Report on Central Precocious Puberty
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Leuprorelin 1-Month (4-Week) Formulation in Children With Central Precocious Puberty Leuprorelin - Central Precocious Puberty | Phase 4 | Recruiting | LG Chem | 43 | 2026-08-01 | 2026-07-29 |
| A Study to Assess the Efficacy, Safety, and Pharmacokinetics of Debio 4326 in Pediatric Participants With Central Precocious Puberty (LIBELULA™ Clinical Trial) Debio 4326 - Central Precocious Puberty | Phase 3 | Active not recruiting | Debiopharm International SA | 56 | 2024-07-31 | 2026-10-23 |
| Efficacy, Metabolism and BMD of the 3-month TP Compared to the 1-month TP in ICPP Triptorelin pamoate（15mg）, Triptorelin acetate （3.75mg） - Central Precocious Puberty | Phase 4 | Not yet recruiting | Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University | 134 | 2024-07-01 | 2024-07-05 |
| A Study of Medical Records From Children With Central Precocious Puberty (CPP) in China Central Precocious Puberty | Completed | Takeda | 1477 | 2023-12-13 | 2026-01-21 | |
| Evaluate the Efficacy and Safety of DWJ108J Leuprolide Acetate 11.25 MG/ML - Central Precocious Puberty | Phase 3 | Unknown | Daewoong Pharmaceutical Co. LTD. | 79 | 2023-08-01 | 2023-09-06 |
| A Study of Leuprolide Acetate Depot in Children With Central Precocious Puberty Leuprorelin Acetate Depot 3M - Central Precocious Puberty | Phase 4 | Completed | Takeda | 79 | 2023-03-12 | 2026-08-04 |
| A Study to Assess the Efficacy and Safety of the Triptorelin 6-month Formulation in Paediatric Participants With Central Precocious Puberty. Triptorelin Pamoate - Central Precocious Puberty | Phase 3 | Completed | Ipsen | 66 | 2021-08-10 | 2025-02-19 |
| Efficacy and Safety Study of Triptorelin 3-Month Formulation in Chinese Children With Central Precocious Puberty. Triptorelin pamoate 15mg - Central Precocious Puberty | Phase 3 | Completed | Ipsen | 32 | 2021-03-27 | 2024-08-01 |
| A Study to Assess the Safety and Efficacy of Enantone (Leuprorelin) in Central Precocious Puberty (CPP) Among Chinese Participants Enantone, GnRH agonist - Central Precocious Puberty | Completed | Takeda | 108 | 2017-06-24 | 2022-03-16 | |
| A Study to Assess the Safety and Efficacy of Leuprorelin in Central Precocious Puberty in Chinese Participants Leuprorelin - Central Precocious Puberty | Phase 4 | Completed | Takeda | 307 | 2015-08-07 | 2022-03-16 |
| Leuprorelin Acetate DPS (Leuplin DPS) Treatment Quarterly in Patients With Central Precocious Puberty Leuplin DPS 11.25mg - Central Precocious Puberty | Phase 4 | Completed | Jin Soon Hwang | 58 | 2015-06-11 | 2020-06-02 |
| Markers of Pubertal Suppression During Therapy for Precocious Puberty Central Precocious Puberty | Terminated | University of Minnesota | 4 | 2013-12-01 | 2018-10-15 | |
| Study of Comprehensive Diagnosis and Treatment for Children Precocious Puberty Triptorlin or Leuprorelin, Zhibo dihuang pills, Dabu ying pills - Central Precocious Puberty | Phase 4 | Completed | Ruijin Hospital | 740 | 2012-09-01 | 2016-09-30 |
| Efficacy, Safety, and Pharmacokinetics (PK) of Triptorelin 6-month Formulation in Patients With Central Precocious Puberty Triptorelin - Central Precocious Puberty | Phase 3 | Completed | Debiopharm International SA | 44 | 2012-04-01 | 2017-07-28 |
| The Clinical Trial to Evaluate the Efficacy and Safety of Luphere Depot Inj. 3.75mg(Leuprolide Acetate 3.75mg) in Patients With Precocious Puberty Luphere depot 3.75mg(Leuprolide acetate 3.75mg) - Central Precocious Puberty | Phase 4 | Completed | Daewoong Pharmaceutical Co. LTD. | 63 | 2011-07-01 | 2014-08-04 |
| Comparative Validation of the Triptorelin Test for the Diagnosis of CPP in Girls Triptorelin acetate and Gonadorelin acetate, Gonadorelin acetate and Triptorelin acetate - Central Precocious Puberty, Sexual Precocity | Phase 3 | Completed | Hospital de Niños R. Gutierrez de Buenos Aires | 46 | 2009-12-01 | 2021-01-06 |
| Histrelin Subcutaneous Implant in Children With Central Precocious Puberty Histrelin Subcutaneous Implant - Central Precocious Puberty | Phase 3 | Completed | Endo USA Inc., a Keenova Therapeutics Company | 36 | 2004-09-01 | 2021-01-08 |
| Analysis of Genetic and Environmental Parameters Influencing Growth Rate of Precocious Puberty Children Triptorelin (GnRH agonists), Leuprolide (GnRH agonists) - Central Precocious Puberty | Phase 4 | Unknown | University of Pisa | 100 | 2007-02-22 |
Puberty, Precocious (18)
Endocrine System Diseases (18) · Gonadal Disorders (18)
Leuprolide (7) · Triptorelin Pamoate (4) · Gonadotropin-Releasing Hormone (1) · Injections (1) · histrelin (1)
Takeda (4) · Daewoong Pharmaceutical Co. LTD. (2) · Debiopharm International SA (2) · Ipsen (2) · Endo USA Inc., a Keenova Therapeutics Company (1) · Hospital de Niños R. Gutierrez de Buenos Aires (1) · Jin Soon Hwang (1) · LG Chem (1) · Ruijin Hospital (1) · Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University (1) · University of Minnesota (1) · University of Pisa (1)
China (7) · South Korea (4) · United States (3) · Argentina (2) · Chile (2) · Mexico (2) · Brazil (1) · Italy (1)
Barry Reiner, MD (1) · Bradley S Miller, MD, PhD (1) · David Domek, MD (1) · Dennis Brenner, MD (1) · Diane Merritt, MD (1) · Douglas Rogers, MD (1) · Erica A Eugster, MD (1) · Erica Eugster, MD (1) · Fan Jiang, Dr (1) · Fernando Cassorla, MD (1) · Gad Kletter, MD (1) · Galal Salem, MD (1)
PMID 16382000, PMID 24295437, PMID 25803268, PMID 28334719, PMID 31319416, PMID 33745030, PMID 34298591, PMID 34463062, PMID 34941067, PMID 36594116, PMID 37584898, PMID 37975727, PMID 39412628