EFFECT OF SHORT-TERM TREATMENT WITH THE SYNBIOTIC PROBINUL-NEUTRO® ON GASTROINTESTINAL SYMPTOMS AND CIRCULATING PLASMA p-CRESOL LEVEL IN PATIENTS WITH CHRONIC RENAL FAILURE: A RANDOMIZED DOUBLE BLIND PILOT STUDY.
| Registry | NCT02008331 |
|---|---|
| Status | Completed |
| Phase | Phase 4 |
| Study type | Interventional; randomized, parallel, masking: double, treatment |
| Enrollment | 30 (Actual) |
| Sponsor | Federico II University (Other) |
| Conditions | Chronic Kidney Disease |
| Interventions | SYNBIOTIC (Dietary supplement) |
| Dates | start 2013-04-01, primary completion 2013-10-01, completion 2013-10-01, first posted 2013-12-11, last updated 2013-12-11 |
| Locations | 1 site in Italy |
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The interest on gastrointestinal (GI) dysfunction in CKD has been growing in the last years. it is now accepted that GI dysfunction in dialyzed patients may contribute to systemic microinflammation by promoting gut dysbiosis and bacterial translocation in the blood. Another mechanism by which GI dysfunction contributes to systemic symptoms in CKD is related to metabolic activity of the dysbiotic microflora growing in the gut of these patients to generate toxic compounds such as phenols, indoles, and amines. Epidemiological evidence has strongly linked one of these compounds, p-Cresol, to cardiovascular risk and mortality in CKD. In the present paper the investigators investigated the effect of a probiotic/prebiotic mixture on plasma p-cresol concentrations and GI symptoms and in CKD patients not on dialysis yet.
In patients with chronic kidney disease (CKD), alterations in gut microbioma are posited to be responsible for gastrointestinal symptoms and generation of p-cresol, a uremic toxin, that has been associated to CKD progression and cardiovascular mortality.
This double blind randomized placebo controlled pilot study evaluates whether Probinul-neutro®, a synbiotic preparation that normalizes intestinal microflora, may lower plasma p-cresol concentrations and reduce gastrointestinal symptoms in non-dialyzed CKD patients.
Thirty patients on III-IV CKD stages were randomized to receive either Probinul neutro® or placebo for four weeks. Total plasma p-cresol concentrations was assessed at baseline, and 15 and 30 days after treatment start. At the same study times, ease and frequency of defecation, upper and lower abdominal pain, stool shape, borborygmi and flatus were quantified by subjective assessment questionnaires.
| Arm | Type | Interventions | Description |
|---|---|---|---|
| SYNBIOTIC | Experimental | Dietary Supplement: SYNBIOTIC | Patients of this group assumed Probinul-Neutro® po 5g three times a day for 30 days |
| PLACEBO | Placebo comparator | patients of this group received 5g of placebo 3 times a day for 30 days |
Sex: All, ages: 18 Years to 80 Years
Inclusion Criteria: * age >18 years * eGFR between 20 and 60 mL/min (stage 3-4 CKD, according to the K/DOQI CKD classification) Exclusion Criteria: * severe infections * diabetes * malignancy * history of food intolerance * autoimmune disorders * severe malnutrition * clinical conditions requiring artificial feeding * kidney transplant
| Facility | City | Country | Status |
|---|---|---|---|
| Federico II University of Naples | Naples, Naples | Italy |