3 completed, 2 active not recruiting, 1 recruiting, 1 terminated. 7 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Completed 3, Active not recruiting 2, Recruiting 1, Terminated 1 |
| Phase 1 | 1 | Completed 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase II Trial of Neoadjuvant and Adjuvant IO102-IO103 and Pembrolizumab KEYTRUDA® in Patients With Resectable Tumors IO102-IO103, Pembrolizumab KEYTRUDA® - Melanoma, Squamous Cell Carcinoma of Head and Neck | Phase 2 | Recruiting | IO Biotech | 60 | 2023-12-21 | 2024-03-18 |
| Neoadjuvant Pembrolizumab and IO102-103 for Squamous Cell Carcinoma of the Head and Neck (SCCHN). Pembrolizumab, IO102-103 - Head and Neck Squamous Cell Carcinoma | Phase 2 | Active not recruiting | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | 30 | 2023-12-14 | 2026-09-22 |
| A Study of IO102/IO103, Nivolumab, and Relatlimab in People With Melanoma IO102/IO103, Nivolumab-Relatlimab - Melanoma | Phase 2 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 43 | 2023-06-09 | 2026-06-01 |
| IO102-IO103 in Combination With Pembrolizumab as First-line Treatment for Patients With Metastatic NSCLC, SCCHN, or mUBC IO102-IO103 in combination with pembrolizumab - Lung Cancer Non Small Cell, Head and Neck Squamous Cell Carcinoma | Phase 2 | Completed | IO Biotech | 63 | 2022-04-11 | 2026-04-08 |
| Peptide Vaccination With PD-L1 and PD-L2 Peptides in Untreated Chronic Lymphatic Leukemia. PD-L1, PD-L2 peptides with Montanide ISA51 - Chronic Lymphocytic Leukemia | Phase 2 | Completed | Lars Møller Pedersen | 19 | 2019-04-26 | 2022-02-21 |
| PD-L1 Peptide Vaccination in High Risk Smoldering Multiple Myeloma PD-L1 peptide - Smoldering Multiple Myeloma | Phase 2 | Terminated | Lene Meldgaard Knudsen | 6 | 2019-02-18 | 2022-04-15 |
| IO102 With Pembrolizumab, With or Without Chemotherapy, as First-line Treatment of Metastatic NSCLC IO102, pembrolizumab (Keytruda), Carboplatin (Carboplatin Kabi) - NSCLC | Phase 1 / Phase 2 | Completed | IO Biotech | 109 | 2018-08-22 | 2022-04-21 |
Squamous Cell Carcinoma of Head and Neck (3) · Melanoma (2) · Carcinoma, Non-Small-Cell Lung (1) · Leukemia, Lymphocytic, Chronic, B-Cell (1) · Neoplasms, Plasma Cell (1) · Smoldering Multiple Myeloma (1)
pembrolizumab (4) · Carboplatin (1) · Opdualag (1) · Pemetrexed (1) · montanide ISA 51 (1)
United States (4) · Denmark (3) · Spain (3) · Germany (2) · United Kingdom (2) · Australia (1) · France (1) · Netherlands (1)
Barbara Burtness, MD, Prof (1) · James Smithy, MD (1) · James Spicer, MD Prof (1) · Jonathan W Riess, MD, MSc (1) · Uffe M Klausen, MD (1) · Wojciech K Mydlarz, M.D., FACS (1)
2018 (3)