ICOS Corporation: Clinical Trials

24 completed, 1 terminated, 1 unknown. 14 Phase 3, 8 Phase 2, 6 Phase 4.

By phase and status

Phase	Trials	Status
Phase 3	14	Completed 12, Terminated 1, Unknown 1
Phase 2	8	Completed 7, Unknown 1
Phase 4	6	Completed 6

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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
Tadalafil Taken Daily Compared to Placebo on Improvement of Getting and Maintaining an Erection and Sexual Quality of Life tadalafil, Placebo - Impotence	Phase 3	Completed	Eli Lilly and Company	342	2006-11-01	2009-06-10
Effects of Tadalafil Once a Day for 12 Weeks in Men With Signs and Symptoms of Benign Prostatic Hyperplasia Tadalafil, Placebo - Benign Prostatic Hyperplasia	Phase 2	Completed	Eli Lilly and Company	200	2006-10-01	2009-07-09
Study of Tadalafil Once-a Day for 12 Weeks in Men With Signs and Symptoms of Benign Prostatic Hyperplasia tadalafil, placebo - Benign Prostatic Hyperplasia	Phase 2 / Phase 3	Completed	Eli Lilly and Company	1058	2006-08-01	2009-09-02
Study the Safety and Effectiveness of Tadalafil on High Blood Pressure in the Blood Vessel Going From the Heart to the Lungs tadalafil - Hypertension, Pulmonary	Phase 3	Completed	Eli Lilly and Company	357	2005-12-01	2013-04-09
Tadalafil in Subjects With Mild to Moderate Hypertension tadalafil - Hypertension	Phase 2	Completed	Eli Lilly and Company	180	2005-09-01	2007-10-25
PHIRST-1: Tadalafil in the Treatment of Pulmonary Arterial Hypertension tadalafil, placebo - Pulmonary Hypertension	Phase 3	Completed	Eli Lilly and Company	406	2005-08-01	2008-02-21
A Study of Visual Effects of Erectile Dysfunction Medications Dosed Daily for Six Months tadalafil - Erectile Dysfunction	Phase 4	Completed	Eli Lilly and Company	198	2005-06-01	2007-10-25
Study to Determine Safety and Effectiveness of Tadalafil on Prostate Related Sex Organ/Urinary Tract Problems tadalafil, placebo - Prostatic Hyperplasia, Prostate	Phase 2	Completed	Eli Lilly and Company	275	2004-10-01	2007-10-22
Effect of Tadalafil on the Quality of Life and Sexual Life in Erectile Dysfunction tadalafil - Impotence, Erectile Dysfunction	Phase 4	Completed	Eli Lilly and Company	200	2004-10-01	2007-10-25
Study the Safety and Effectiveness of Tadalafil in Men With Diabetes Who Have Problems Getting and Keeping an Erection tadalafil, placebo - Impotence	Phase 3	Completed	Eli Lilly and Company	298	2004-10-01	2007-10-22
Efficacy and Safety of Tadalafil in Subjects With Erectile Dysfunction Caused by Spinal Cord Injury tadalafil - Erectile Dysfunction, Spinal Cord Injuries	Phase 3	Completed	Eli Lilly and Company	180	2004-09-01	2007-10-25
Study to Determine a Preference Between Sildenafil or Tadalafil Treatment for Problems Getting an Erection tadalafil, sildenafil - Impotence	Phase 4	Completed	Eli Lilly and Company	160	2004-06-01	2007-10-22
Study the Safety and Effectiveness of Tadalafil in Men With Problems Getting or Maintaining an Erection When Taken Prior to Desiring an Erection tadalafil, placebo - Impotence	Phase 3	Completed	Eli Lilly and Company	343	2004-03-01	2007-10-22
A Study of Semen Characteristics After 9 Months of Daily Tadalafil 20 mg tadalafil, placebo - Erectile Dysfunction	Phase 4	Completed	Eli Lilly and Company	282	2003-11-01	2007-10-25
A Study to Evaluate the Efficacy and Safety of 2.5mg and 5mg Tadalafil Given Once a Day to Men With Erectile Dysfunction tadalafil, placebo - Erectile Dysfunction	Phase 3	Completed	Eli Lilly and Company	280	2003-10-01	2007-11-07
Study For Which Treatment, Tadalafil or Sildenafil, is Preferred For Problems Getting or Maintaining an Erection tadalafil, sildenafil - Impotence	Phase 4	Completed	Eli Lilly and Company	386	2003-10-01	2007-10-22
To Determine Effect and Safety of Tadalafil Taken by Men of Different Races and With Different Diseases When Needed for Erections tadalafil - Impotence	Phase 3	Completed	Eli Lilly and Company	1933	2003-07-01	2007-10-22
Determine Safety and Effectiveness of Tadalafil in Asian Men When Taken as Needed for Getting and Keeping an Erection tadalafil, placebo - Impotence	Phase 3	Completed	Eli Lilly and Company	367	2003-04-01	2007-10-22
Determine If the Stress That Comes With Not Developing an Erection Affects Tadalafil Effects tadalafil - Impotence	Phase 4	Completed	Eli Lilly and Company	659	2003-04-01	2007-10-22
Study of Tadalafil for the Treatment of Diabetic Patients With Symptoms of Upset Stomach and Delayed Stomach Emptying tadalafil, placebo - Gastroparesis	Phase 2	Completed	Eli Lilly and Company	2	2003-02-01	2007-11-20

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Conditions studied

Erectile Dysfunction (15)  ·  Hypertension, Pulmonary (3)  ·  Prostatic Hyperplasia (3)  ·  Hypertension (2)  ·  Sepsis (2)  ·  Community-Acquired Pneumonia (1)  ·  Cystitis, Interstitial (1)  ·  Gastroparesis (1)  ·  Pneumonia (1)  ·  Pulmonary Heart Disease (1)  ·  Spinal Cord Injuries (1)

Interventions

Tadalafil (22)  ·  Sildenafil Citrate (3)  ·  Cystoscopy (1)  ·  Hematologic Tests (1)  ·  epicatechin gallate (1)

Countries

United States (17)  ·  Canada (3)  ·  France (3)  ·  Germany (3)  ·  Italy (2)  ·  Japan (2)  ·  United Kingdom (2)  ·  Austria (1)  ·  Belgium (1)  ·  Brazil (1)  ·  China (1)  ·  Finland (1)  ·  Greece (1)  ·  Ireland (1)  ·  Mexico (1)

Top investigators

Lyn Frumkin, M.D., Ph.D. (2)

Results publications

PMID 23035781, PMID 24119319, PMID 18722631, PMID 19365010, PMID 19409693, PMID 19470885, PMID 20163842, PMID 22818063, PMID 26299520, PMID 34379314