3 recruiting, 2 active not recruiting, 2 completed. 7 Phase 2, 4 Phase 3, 2 Phase 1.
By phase and status
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Trials (filtered) newest first · largest first
All 7 trials
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-003)
Tiespectus, Aflibercept - Macular Degeneration, Age-Related Macular Degeneration | Phase 2 / Phase 3 | Recruiting | 960 | 2026-04-15 | 2026-08-06 |
A Clinical Trial of EYE201/MK-8748 in People With Macular Degeneration (MK-8748-002)
Tiespectus, Aflibercept - Macular Degeneration, Age-Related Macular Degeneration | Phase 2 / Phase 3 | Recruiting | 960 | 2026-03-27 | 2026-10-02 |
A Dose-masked Study of Intravitreal Remigromig (EYE103) in Participants With NVAMD or Macular Edema Following BRVO
Remigromig, Aflibercept 2.0 mg - Neovascular Age-Related Macular Degeneration (NVAMD), Branch Retinal Vein Occlusion (BRVO) | Phase 2 | Recruiting | 160 | 2025-09-12 | 2026-10-20 |
A Study of 2 Doses of Remigromig (EYE103) Compared With Ranibizumab (0.5 mg) in Participants With DME
Remigromig, Ranibizumab - Diabetic Macular Edema (DME) | Phase 2 / Phase 3 | Active not recruiting | 1054 | 2025-04-16 | 2026-10-30 |
A 2-part Study Consisting of a Multiple Ascending Dose Safety Study in Participants With Macular Edema Following Branch Retinal Vein Occlusion and a Dose-finding Safety and Preliminary Efficacy Study in Participants With Either Diabetic Macular Edema or Neovascular Age-related Macular Degeneration
EYE201 - Diabetic Macular Edema (DME), Neovascular Age-related Macular Degeneration (NVAMD) | Phase 1 / Phase 2 | Completed | 38 | 2024-11-12 | 2026-08-24 |
A Study to Evaluate the Efficacy and Safety of 2 Doses of Remigromig (EYE103) Compared With Ranibizumab (0.5 mg) in Participants With DME
Ranibizumab, Remigromig - Diabetic Macular Edema (DME) | Phase 2 / Phase 3 | Active not recruiting | 984 | 2024-08-07 | 2026-10-14 |
A 2-part Study Consisting of Multiple Ascending Dose (MAD) Safety Study, and a Dose-finding Masked Study to Assess the Safety and Efficacy of Intravitreal (IVT) Remigromig (EYE103) in Patients With Diabetic Macular Edema (DME) or Neovascular Age-related Macular Degeneration (NVAMD)
Remigromig - Neovascular Age-related Macular Degeneration (NVAMD), Diabetic Macular Edema (DME) | Phase 1 / Phase 2 | Completed | 33 | 2023-06-12 | 2026-11-03 |
Conditions studied
Macular Degeneration (3) · Choroidal Neovascularization (2) · Retinal Vein Occlusion (2) · Wet Macular Degeneration (2)
Interventions
aflibercept (3) · Ranibizumab (2)
Countries
United States (7) · Puerto Rico (5) · Argentina (4) · Colombia (3) · Spain (3) · United Kingdom (3) · Australia (2) · Brazil (2) · Czechia (2) · France (2) · Germany (2) · Hungary (2) · Israel (2) · Italy (2) · Latvia (2)
Top investigators
Charles Miller, MD PhD (3)
NIH funding
2025 (1)