10 completed, 2 recruiting, 1 enrolling by invitation. 13 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 13 | Completed 10, Recruiting 2, Enrolling by invitation 1 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Effect of Sage Extract Supplementation on Cognitive Function in Middle-Aged Men and Women SageXtra, Placebo - Cognitive Ability, General | Not applicable | Recruiting | ESM Technologies, LLC | 64 | 2026-02-15 | 2026-08-11 |
| Effects of Eggshell Membrane and Curcumin Extract Supplementation, Separately or Combined, on Recovery From Intense Exercise NEM® brand eggshell membrane powder, curQ+® brand highly absorbable curcumin, EM Placebo - Exercise-induced Muscle Soreness, Exercise-induced Joint Pain | Not applicable | Recruiting | ESM Technologies, LLC | 60 | 2026-02-01 | 2026-08-14 |
| Ovolux Beauty From Within Trial#2 Ovolux brand eggshell membrane powder, Placebo - Skin Sagging, Skin Wrinkling | Not applicable | Enrolling by invitation | ESM Technologies, LLC | 100 | 2025-09-22 | 2025-12-18 |
| Enhanced Absorption of curQ+ or Liposomal Curcumin Formulations Versus 95% Curcumin Powder in Healthy Subjects 95% curcumin extract powder, curQ+ curcumin formulation, liposomal curcumin formulation - Bioavailability | Not applicable | Completed | ESM Technologies, LLC | 25 | 2024-03-01 | 2026-08-07 |
| Eggshell Membrane Beauty From Within Trial unhydrolyzed eggshell membrane, Placebo - Skin Elasticity, Skin Hydration | Not applicable | Completed | ESM Technologies, LLC | 63 | 2023-12-27 | 2025-09-16 |
| NEM® + BIOCURC® Versus Placebo in Exercised-induced Joint Pain, Stiffness, & Cartilage Turnover in Healthy Men & Women NEM® + BIOCURC®, Placebo - Exercise-induced Joint Pain, Exercise-induced Joint Stiffness | Not applicable | Completed | ESM Technologies, LLC | 84 | 2019-01-13 | 2019-07-18 |
| NEM® Versus Placebo in Exercised-induced Joint Pain, Stiffness, & Cartilage Turnover in Healthy Men & Women NEM® brand eggshell membrane, Placebo - Exercise-induced Joint Pain, Exercise-induced Joint Stiffness | Not applicable | Completed | ESM Technologies, LLC | 84 | 2018-09-20 | 2024-09-19 |
| NEM® + KD PUR® Fish Oil Versus Placebo in Exercised-induced Joint Pain, Stiffness, & Cartilage Turnover in Healthy Men & Women Move3™ (NEM® brand eggshell membrane + KD PUR® brand fish oil), Placebo - Exercise-induced Joint Pain, Exercise-induced Joint Stiffness | Not applicable | Completed | ESM Technologies, LLC | 85 | 2018-09-20 | 2024-04-30 |
| Evaluation of Increased Absorption of a Curcumin Emulsion (CurQ+) in Healthy Volunteers 95% Curcuminoid Powder, CurQ+ - Bioavailability | Not applicable | Completed | ESM Technologies, LLC | 10 | 2018-03-27 | 2021-12-13 |
| NEM® Versus Placebo on Exercise-induced Joint Pain, Stiffness, & Cartilage Turnover In Healthy, Post-Menopausal Women NEM, Placebo - Exercise-induced Joint Pain Stiffness and Cartilage Turnover | Not applicable | Completed | ESM Technologies, LLC | 60 | 2015-12-01 | 2018-08-17 |
| Efficacy & Safety Study Evaluating Natural Eggshell Membrane (NEM) in the Treatment of Osteoarthritis NEM, Placebo - Osteoarthritis | Not applicable | Completed | ESM Technologies, LLC | 67 | 2004-12-01 | 2016-02-15 |
| Efficacy & Safety Study of Natural Eggshell Membrane (NEM) for the Treatment of Joint & Connective Tissue Disorders NEM Formulation X, NEM Formulation Y - Osteoarthritis, Fibromyalgia | Not applicable | Completed | ESM Technologies, LLC | 28 | 2003-11-01 | 2023-09-07 |
| Pilot Study of the Efficacy & Safety of Natural Eggshell Membrane (NEM) for Joint & Connective Tissue Disorders NEM - Osteoarthritis, Fibromyalgia | Not applicable | Completed | ESM Technologies, LLC | 11 | 2003-10-01 | 2023-09-07 |
Arthralgia (4) · Arthritis (3) · Osteoarthritis (3) · Connective Tissue Diseases (2) · Fibromyalgia (2)
United States (12)
Kevin J Ruff, Ph.D., MBA (3) · Kevin J. Ruff, Ph.D. (3) · Kevin Ruff, Ph.D. (3) · Kayce Morton, D.O. (2) · Anne Winkler, MD, PhD (1) · Christopher Bailey, Ph.D. (1) · Dennis Morrison, D.O. (1) · Karen L Posey, PhD (1) · Kevin J Ruff, PhD (1) · Kevin J Ruff, PhD, MBA (1) · Mark A Robinson, D.C. (1) · Michael D Leu, D.Ph., N.D. (1) · Richard B. Kreider, Ph.D. (1) · Robert W Jackson, DO (1)