6 completed, 2 active not recruiting, 1 not yet recruiting, 1 unknown. 5 Phase 2, 4 Phase 3, 2 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 3, Active not recruiting 2 |
| Phase 3 | 4 | Completed 2, Not yet recruiting 1, Unknown 1 |
| Phase 1 | 2 | Completed 2 |
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Docetaxel Plus Plinabulin vs Docetaxel Plus Placebo in Advanced/Metastatic Non-Squamous NSCLC After PD-1/PD-L1 Therapy and Platinum Chemotherapy (DUBLIN-4) Plinabulin, Docetaxel, Placebo (matching plinabulin placebo) - Non-Small Cell Lung Cancer, Non-squamous Non-Small Cell Lung Cance | Phase 3 | Not yet recruiting | BeyondSpring Pharmaceuticals Inc. | 442 | 2026-12-01 | 2026-09-29 |
| Pembrolizumab in Combination With Plinabulin and Docetaxel For Metastatic NSCLC After ICIs (KeyPemls-004) Pembrolizumab in Combination with Plinabulin and Docetaxel - Non Small Cell Lung Cancer Metastatic | Phase 2 | Active not recruiting | Peking Union Medical College Hospital | 47 | 2023-02-01 | 2026-07-28 |
| Study of Plinabulin and Pegfilgrastim in People With Multiple Myeloma Undergoing an Autologous Hematopoietic Stem Cell Transplant (AHCT) Plinabulin - Multiple Myeloma | Phase 2 | Active not recruiting | Memorial Sloan Kettering Cancer Center | 17 | 2021-12-21 | 2025-12-24 |
| Plinabulin vs. Pegfilgrastim in Prevention of TAC Induced Neutropenia Pegfilgrastim, Plinabulin, D5W Placebo - Chemotherapy-induced Neutropenia | Phase 3 | Unknown | BeyondSpring Pharmaceuticals Inc. | 221 | 2019-10-23 | 2021-01-15 |
| A Phase I/II Study of Nivolumab, Ipilimumab and Plinabulin in Patients With Recurrent Small Cell Lung Cancer Nivolumab, Plinabulin, Ipilimumab - Lung Cancer, SCLC | Phase 1 / Phase 2 | Completed | Salma Sabbour | 39 | 2018-09-06 | 2026-01-20 |
| Plinabulin vs. Pegfilgrastim in Patients With Solid Tumors Receiving Docetaxel Myelosuppressive Chemotherapy Phase 3 Plinabulin, Pegfilgrastim, Saline Placebo - Chemotherapy-induced Neutropenia | Phase 3 | Completed | BeyondSpring Pharmaceuticals Inc. | 105 | 2018-05-29 | 2024-08-29 |
| Plinabulin iv Solution in Prevention of TAC Induced Neutropenia Plinabulin, Pegfilgrastim, Docetaxel, doxorubicin, and cyclophosphamide (TAC) - Chemotherapy-induced Neutropenia | Phase 2 | Completed | BeyondSpring Pharmaceuticals Inc. | 115 | 2017-11-27 | 2020-01-18 |
| Plinabulin vs. Pegfilgrastim in Patients With Solid Tumors Receiving Docetaxel Myelosuppressive Chemotherapy Phase 2 Plinabulin, Pegfilgrastim - Chemotherapy-induced Neutropenia | Phase 2 | Completed | BeyondSpring Pharmaceuticals Inc. | 55 | 2017-04-05 | 2024-05-16 |
| Nivolumab in Combination With Plinabulin in Patients With Metastatic Non-Small Cell Lung Cancer (NSCLC) Nivolumab + Plinabulin - Non-small Cell Lung Cancer Metastatic | Phase 1 | Completed | Lyudmila Bazhenova, M.D. | 18 | 2016-08-29 | 2025-11-12 |
| Docetaxel + Plinabulin Compared to Docetaxel + Placebo in Patients With Advanced NSCLC Docetaxel + Plinabulin (DP), Docetaxel (D) - Non-Small Cell Lung Cancer | Phase 3 | Completed | BeyondSpring Pharmaceuticals Inc. | 559 | 2015-12-01 | 2026-05-19 |
Carcinoma, Non-Small-Cell Lung (4) · Lung Neoplasms (1) · Multiple Myeloma (1) · Neoplasm Metastasis (1) · Neoplasms (1)
NPI 2358 (10) · Docetaxel (5) · pegfilgrastim (4) · Granulocyte Colony-Stimulating Factor (3) · Cyclophosphamide (2) · Doxorubicin (2) · Nivolumab (2) · Fumigant 93 (1) · Ipilimumab (1) · pembrolizumab (1)
China (6) · United States (6) · Ukraine (4) · Russia (2) · Australia (1)
Douglas Blayney, M.D. (1) · Douglas W. Blayney, MD (1) · Gunjan Shah, MD, MS (1) · Lyudmilla Bazhenova, MD (1) · Salma Jabbour, MD (1)