8 completed, 2 terminated, 1 unknown. 6 Phase 3, 4 Phase 2, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 6 | Completed 5, Terminated 1 |
| Phase 2 | 4 | Completed 2, Terminated 1, Unknown 1 |
| Phase 1 | 1 | Completed 1 |
Follow Uracil: new trials by email Literature Review of Uracil trials Research Report on Uracil
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Phase II Trial of PG2 in Patients With Advanced Pharyngeal or Laryngeal Squamous Cell Carcinoma Under Concurrent Chemoradiotherapy Astragalus polysaccharides 500 mg, Placebo, Concurrent chemoradiotherapy with PUL (cisplatin/tegafur plus uracil (UFT)/leucovorin) every 2 weeks - Cancer-related Fatigue | Phase 2 | Terminated | PhytoHealth Corporation | 17 | 2012-12-01 | 2025-06-04 |
| Safety and Pharmacokinetic Study of C13-URA in Healthy Volunteers [2-13C] uracil, [2-13C] uracil, placebo - Gastroparesis | Phase 1 | Completed | Otsuka Pharmaceutical Co., Ltd. | 8 | 2010-02-01 | 2010-07-19 |
| Erbitux Study of CPT11, Oxaliplatin, UFToral Targeted Therapy Cetuximab, Irinotecan, Oxaliplatin - Metastatic Colorectal Cancer | Phase 2 | Completed | The Christie NHS Foundation Trust | 47 | 2009-04-01 | 2014-06-11 |
| Sorafenib Plus Tegafur/Uracil (UFUR®) for Hepatocellular Carcinoma (HCC) Sorafenib, tegafur/uracil (UFUR®) - Hepatocellular Carcinoma | Phase 2 | Completed | National Taiwan University Hospital | 50 | 2007-04-01 | 2009-07-07 |
| Trial Testing Ftorafur (UFT) Associated With Neoadjuvant Radiotherapy Versus Radiotherapy Alone in Rectal Adenocarcinoma Tegafur and Uracil - Rectal Cancer, Stage II/III | Phase 3 | Terminated | Institut Cancerologie de l'Ouest | 219 | 2004-07-01 | 2020-03-25 |
| A Randomized Controlled Study of Postoperative Adjuvant Chemotherapy of Uracil- Tegafur (UFT) Compared With Surgery Alone (NSAS-GC) UFT (uracil, tegafur), Surgery alone - Gastric Cancer | Phase 3 | Completed | Taiho Pharmaceutical Co., Ltd. | 500 | 1997-06-01 | 2011-07-07 |
| Combination Chemotherapy in Treating Patients With Resected Colon Cancer 5-fluorouracil, leucovorin calcium, tegafur - Colorectal Cancer | Phase 3 | Completed | NSABP Foundation Inc | 1608 | 1997-02-01 | 2010-01-11 |
| A Randomized Controlled Study of Postoperative Adjuvant Chemotherapy of Uracil- Tegafur (UFT) Compared With Surgery Alone (NSAS-CC) UFT (uracil, tegafur), Surgery alone - Colorectal Cancer | Phase 3 | Completed | Taiho Pharmaceutical Co., Ltd. | 900 | 1996-10-01 | 2011-07-07 |
| A Randomized Controlled Study of Postoperative Adjuvant Therapy of Uracil-tegafur (UFT) Compared With Cyclophosphamide/Methotrexate/5-fluorouracil (CMF) in Breast Cancer (NSAS-BC) UFT (uracil, tegafur), cyclophosphamide, methotrexate, and fluorouracil - Breast Cancer | Phase 3 | Completed | Taiho Pharmaceutical Co., Ltd. | 1300 | 1996-10-01 | 2011-07-07 |
| The Comparative Trial of UFT + TAM With CMF + TAM in Adjuvant Therapy for Breast Cancer (CUBC) UFT (uracil, tegafur) and tamoxifen, CMF(cyclophosphamide, methotrexate, fluorouracil) and tamoxifen - Breast Cancer | Phase 3 | Completed | Taiho Pharmaceutical Co., Ltd. | 680 | 1996-07-01 | 2011-07-07 |
| A Phase II Study of Paclitaxel, UFT, and Leucovorin in Patients With Metastatic Esophageal Cancer UFT (Tegafur/Uracil) - Esophageal Neoplasm | Phase 2 | Unknown | Edelman, Martin, M.D. | 2005-06-24 |
Colorectal Neoplasms (3) · Breast Neoplasms (2) · Carcinoma, Hepatocellular (1) · Colonic Neoplasms (1) · Esophageal Neoplasms (1) · Gastroparesis (1) · Rectal Neoplasms (1) · Squamous Cell Carcinoma of Head and Neck (1) · Stomach Neoplasms (1)
Taiho Pharmaceutical Co., Ltd. (4) · Edelman, Martin, M.D. (1) · Institut Cancerologie de l'Ouest (1) · NSABP Foundation Inc (1) · National Taiwan University Hospital (1) · Otsuka Pharmaceutical Co., Ltd. (1) · PhytoHealth Corporation (1) · The Christie NHS Foundation Trust (1)
Japan (4) · Taiwan (2) · United States (2) · France (1) · United Kingdom (1)
Chih-Hung Hsu, M.D.Ph.D (1) · Christian Chevelle, MD (1) · Hiroki Koyama, MD (1) · Hung-Ming HM Wang, MD (1) · Mark Saunders (1) · Michael J. O'Connell, MD (1) · Patrice Cellier, MD (1) · Shigeaki Yoshida, MD (1) · Stephen D Flach, MD, PhD, CPI (1) · Toru Watanabe, MD (1) · Toshifusa Nakajima, MD (1)
PMID 11098486, PMID 16648506, PMID 16675478, PMID 16945170, PMID 17264338, PMID 17948223, PMID 19204202, PMID 19638976, PMID 21338641
U10CA012027 (1)