21 completed, 2 unknown. 10 Phase 3, 7 Phase 2, 4 Phase 1, 2 Phase 4, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 10 | Completed 8, Unknown 2 |
| Phase 2 | 7 | Completed 7 |
| Phase 1 | 4 | Completed 4 |
| Phase 4 | 2 | Completed 2 |
| Not applicable | 1 | Completed 1 |
Follow Sublingual Immunotherapy: new trials by email Literature Review of Sublingual Immunotherapy trials Research Report on Sublingual Immunotherapy
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Serum sST2/ miR-223 as a Dual Biomarker for Disease Activity & Clinical Efficacy of SLIT in HDM-Induced Allergic Rhinitis Sublingual Immunotherapy (SLIT) containing HDM extracts - HDM-Induced Allergic Rhinitis | Phase 1 | Completed | Zagazig University | 54 | 2025-02-01 | 2026-02-27 |
| Serum MicroRNAs 223 and 146a in Allergic Rhinitis Patients as Biomarkers for Efficacy of Sublingual Immunotherapy Sublingual immunotherapy - Effects of Immunotherapy | Phase 3 | Completed | Zagazig University | 64 | 2021-07-27 | 2022-12-20 |
| Effect of Sublingual Immunotherapy on Platlet factor4 Level in Children sublingual immunotherapy - Allergic Rhinitis | Phase 3 | Unknown | Zagazig University | 30 | 2021-04-12 | 2021-04-21 |
| Grass Pollen Immunotherapy Plus Dupilumab for Tolerance Induction Dupixent®, Grazax®, Dupixent® Placebo - Allergic Rhinoconjunctivitis, Grass Pollen Allergy | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 199 | 2020-11-05 | 2026-04-27 |
| Effect of Sublingual Immunotherapy in Patients With Atopic Dermatitis Mite extract sublingual immunotherapy (SLIT), Placebo - Atopic Dermatitis, Effects of Immunotherapy | Phase 4 | Completed | Casa Espirita Terra de Ismael | 91 | 2018-05-02 | 2020-08-26 |
| Efficacy and Safety of Sublingual Immunotherapy (SLIT) sublingual immunotherapy with allergen extract, sublingual immunotherapy with placebo - Allergic Rhinitis | Phase 3 | Unknown | Roxall Medizin | 120 | 2016-11-01 | 2015-11-03 |
| Tolerability of SLIT With LAIS® Mites Allergoid Tablets Sublingual Immunotherapy with tablets (mites) - Allergic Rhinitis | Completed | University Hospital of Cologne | 192 | 2015-12-01 | 2017-10-25 | |
| Dose Ranging Study of SLIT Tablets of House Dust Mite Allergen Extracts (HDM) in Adults With HDM-associated Allergic Asthma SLIT tablets of HDM allergen extracts, 3 different doses (A), SLIT tablets of HDM allergen extracts, 3 different doses (B), SLIT tablets of HDM allergen extracts, 3 different doses (C) - Asthma, House Dust Mite Allergy | Phase 2 | Completed | Stallergenes Greer | 386 | 2013-09-01 | 2015-12-18 |
| Safety Study of Sublingual Immunotherapy Tablets of House Dust Mite Allergen Extracts in Adolescents 500 IR house dust mites allergen extract tablet, 1000 IR house dust mites allergen extract tablet, 1500 IR house dust mites allergen extract tablet - Allergic Rhinitis Due to House Dust Mite | Phase 1 | Completed | Stallergenes Greer | 37 | 2013-07-01 | 2025-01-17 |
| Long-Term Effects of Sublingual Grass Therapy Sublingual immunotherapy (SLIT), Subcutaneous immunotherapy (SCIT), Placebo - Rhinitis, Allergic, Seasonal | Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 106 | 2011-03-01 | 2017-06-02 |
| Efficacy and Safety of 100IR, 300IR, 500IR Sublingual House Dust Mite Tablets in Allergic Rhinitis Environment Exposure Chamber Model 100 IR house dust mites allergen extract tablet, 300 IR house dust mites allergen extract tablet, 500 IR house dust mites allergen extract tablet - Allergic Rhinitis Due to House Dust Mite | Phase 2 | Completed | Stallergenes Greer | 355 | 2010-12-08 | 2025-02-04 |
| SUBLIVAC® Birch PROBE Study sublingual immunotherapy - Seasonal Rhinitis and/or Rhinoconjunctivitis, Birch Pollen Allergy | Phase 2 | Completed | HAL Allergy | 74 | 2009-07-01 | 2012-02-07 |
| Safety and Efficacy on Phase III Study on 300 IR SLIT to Patients Suffering From Grass Pollen Rhinoconjunctivitis 300 IR, Placebo - Primary Disease | Phase 3 | Completed | Stallergenes Greer | 381 | 2009-01-01 | 2016-05-25 |
| Study of Efficacy and Safety of 300 IR Sublingual Immunotherapy (SLIT) Tablets in Adult Patients With Allergic Grass Pollen Rhinoconjunctivitis 300 IR, Placebo - Allergic Rhinitis Due to Grass Pollens | Phase 3 | Completed | Stallergenes Greer | 473 | 2008-10-01 | 2016-05-19 |
| Safety and Efficacy Study of Sublingual Immunotherapy (SLIT) to Treat House Dust Mite Allergic Rhinitis 300 IR house dust mites allergen extract tablet, 500 IR house dust mites allergen extract tablet, Placebo tablet - Allergic Rhinitis | Phase 2 / Phase 3 | Completed | Stallergenes Greer | 509 | 2007-10-01 | 2016-05-19 |
| Efficacy and Safety of Sublingual Tablets of Grass Pollen Allergen Extract 300 IR grass pollen allergen extract tablet, Placebo tablet - Seasonal Allergic Rhinitis | Phase 1 | Completed | Stallergenes Greer | 89 | 2007-09-01 | 2016-05-23 |
| Phase III Study to Assess the Long Term Efficacy, Carry-over Effect and Safety of 300 IR Sublingual Immunotherapy Tablets 300 IR (4M), 300 IR (2M), Placebo - Allergy | Phase 3 | Completed | Stallergenes Greer | 633 | 2006-12-01 | 2016-05-25 |
| Efficacy and Safety of 300 IR Sublingual Immunotherapy (SLIT) Tablets in Children Suffering From Grass Pollen Rhinoconjunctivitis 300 IR grass pollen allergen extract tablet, Placebo tablet - Allergy | Phase 3 | Completed | Stallergenes Greer | 278 | 2006-12-01 | 2016-05-26 |
| Immunotherapy for Peanut Allergy Sublingual immunotherapy - Allergy | Not applicable | Completed | University of North Carolina, Chapel Hill | 7 | 2006-04-01 | 2016-06-20 |
| Sublingual Immunotherapy In Alternaria-Induced Rhinitis sublingual immunotherapy, placebo - Allergic Rhinitis (w/w Asthma) Due to Alternaria Alternata | Phase 4 | Completed | University of Genova | 27 | 2006-01-01 | 2010-06-07 |
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Rhinitis, Allergic (8) · Hypersensitivity (6) · Asthma (2) · Rhinitis (2) · Rhinitis, Allergic, Seasonal (2) · Conjunctivitis (1) · Dermatitis, Atopic (1) · Dust Mite Allergy (1) · Eczema (1) · Peanut Hypersensitivity (1) · Pruritus (1)
Stallergenes Greer (10) · Zagazig University (3) · National Institute of Allergy and Infectious Diseases (NIAID) (2) · ALK-Abelló A/S (1) · Casa Espirita Terra de Ismael (1) · HAL Allergy (1) · Roxall Medizin (1) · Stanford University (1) · University Hospital of Cologne (1) · University of Genova (1) · University of North Carolina, Chapel Hill (1)
Germany (5) · France (3) · United States (3) · Canada (2) · Egypt (2) · Italy (2) · United Kingdom (2) · Austria (1) · Brazil (1) · Poland (1) · Spain (1)
Hanaa A Nofal, MD (1) · Hendrik Wolf, PhD (1) · Kari Nadeau, MD, PhD (1) · Karla L Arruda, PhD (1) · Ludger Klimek, PhD (1) · Margitta Worm, MD, Prof. (1) · Mohammad Romeh (1) · Oliver Pfaar, MD (1) · Pascal Demoly, MD (1)
PMID 39035788, PMID 17935764, PMID 19046761, PMID 19647862, PMID 21055665, PMID 21802126, PMID 22994348, PMID 23122534, PMID 23181790, PMID 23600548, PMID 24261946, PMID 24388010, PMID 26097680, PMID 27329923, PMID 28196255, PMID 37460024, PMID 42711401
2018 (1)