5 recruiting, 4 completed, 3 unknown, 1 active not recruiting. 6 Phase 2, 3 Not applicable, 3 Phase 1, 1 Phase 3, 1 Phase 4.
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Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Yttrium-90 Carbon Microsphere Radioembolization in Previously Treated Hepatocellular Carcinoma NRT6003 Injection - Hepatocellular Carcinoma | Phase 2 | Not yet recruiting | Second Affiliated Hospital of Guangzhou Medical University | 20 | 2026-06-22 | 2026-06-18 |
| Evaluation of SIRT Followed by Immunotherapy for Treatment of Hepatocellular Carcinoma With Portal Vein Thrombosis Selective Internal Radiotherapy, Tremelimumab, Durvalumab - Hepatocellular Carcinoma Non-resectable | Phase 2 | Recruiting | Center Eugene Marquis | 80 | 2026-02-25 | 2026-05-05 |
| SIRT Versus cTACE for Unresectable HCC (CHANCE2506) SIRT, cTACE - Unresectable Hepatocellular Carcinoma | Not applicable | Recruiting | Zhongda Hospital | 108 | 2025-04-03 | 2025-04-09 |
| Y-90 SIRT for Unresectable HCC Larger Than 7cm SIRT - Hepatocellular Carcinoma Non-Resectable | Phase 2 | Recruiting | Second Affiliated Hospital of Guangzhou Medical University | 33 | 2024-12-01 | 2025-01-28 |
| SIRT for Potentially Resectable HCC SIRT - Hepatocellular Carcinoma | Not applicable | Recruiting | Second Affiliated Hospital of Guangzhou Medical University | 35 | 2023-08-10 | 2023-09-14 |
| Observational SIR-Spheres Study for the Treatment of Unresectable Liver Tumors (SIRtain Registry) SIRT - Unresectable Hepatocellular Carcinoma (HCC), Liver Metastases From Colorectal Cancer (mCRC) | Recruiting | Sirtex Medical | 845 | 2023-06-19 | 2024-11-27 | |
| SIRT With Tremelimumab and Durvalumab for Resectable HCC Durvalumab, Tremelimumab, SIRT - Resectable Hepatocellular Carcinoma, Hepatocellular Carcinoma | Phase 1 | Active not recruiting | Jiping Wang, MD, PhD | 20 | 2023-04-21 | 2026-08-13 |
| TILA-TACE in Treatment of Hepatocellular Carcinoma TILA-TACE treatment - Tumor Response Rate, Overall Survival | Not applicable | Unknown | Second Affiliated Hospital, Zhejiang University, School of Medicine | 2000 | 2017-11-01 | 2019-04-10 |
| Transarterial Radioembolisation in Comparison to Transarterial Chemoembolisation in Uveal Melanoma Liver Metastasis SIRT, DSM-TACE - Uveal Melanoma | Phase 2 | Completed | Charite University, Berlin, Germany | 108 | 2016-01-01 | 2025-01-24 |
| Comparing HAI-90Y (SIR-spheres)+Chemotx LV5FU2 Versus Chemotx LV5FU2 Alone to Treat Colorectal Cancer HAI-90Y radioembolization (SIR-spheres injection), systemic chemotherapy LV5FU2 - Colorectal Cancer | Phase 3 | Unknown | Universiteit Antwerpen | 162 | 2013-08-01 | 2017-07-07 |
| Y90 Radioembolization Prior to Surgical Resection or Radiofrequency for Hepatocellular Carcinoma in Cirrhotic Liver Sirsphere trans-arterial radioembolization - Hepatocellular Carcinoma, Liver Cirrhosis | Phase 2 | Terminated | Jules Bordet Institute | 10 | 2012-09-01 | 2015-07-01 |
| Pasireotide, Everolimus and Selective Internal Radioembolization Therapy for Unresectable Hepatic Metastases Pasireotide, Sir-sphere Radioembolization, Everolimus - Neuroendocrine Tumors | Phase 1 | Completed | Emory University | 13 | 2011-12-01 | 2018-10-18 |
| Selective Internal Radiotherapy (SIRT) Versus Transarterial Chemoembolisation (TACE) for the Treatment of Cholangiocellular Carcinoma (CCC). DEB TACE, SIRT - Intrahepatic Cholangiocellular Carcinoma | Phase 2 | Unknown | Johannes Gutenberg University Mainz | 24 | 2011-02-01 | 2017-05-23 |
| Selective Internal Radiation Therapy (SIRT) Versus Transarterial Chemoembolisation (TACE) for the Treatment of Hepatocellular Carcinoma (HCC). DEB TACE, SIRT - Hepatocellular Carcinoma | Phase 4 | Completed | Johannes Gutenberg University Mainz | 24 | 2010-02-01 | 2015-10-20 |
| Study of Capecitabine in Combination With SIR-Spheres in Patients With Advanced Cancer SIRT, capecitabine - Metastatic Liver Cancer | Phase 1 | Completed | Fox Chase Cancer Center | 34 | 2006-04-01 | 2015-09-07 |
Carcinoma, Hepatocellular (7) · Liver Neoplasms (4) · Cholangiocarcinoma (1) · Colorectal Neoplasms (1) · Liver Cirrhosis (1) · Neuroendocrine Tumors (1) · Uveal Melanoma (1)
Second Affiliated Hospital of Guangzhou Medical University (3) · Johannes Gutenberg University Mainz (2) · Center Eugene Marquis (1) · Charite University, Berlin, Germany (1) · Emory University (1) · Fox Chase Cancer Center (1) · Jiping Wang, MD, PhD (1) · Jules Bordet Institute (1) · Second Affiliated Hospital, Zhejiang University, School of Medicine (1) · Sirtex Medical (1) · Universiteit Antwerpen (1) · Zhongda Hospital (1)
China (5) · United States (3) · Belgium (2) · France (2) · Germany (2) · Spain (1) · United Kingdom (1)
Alain Hendlisz, MD (1) · Bassel El-Rayes, MD (1) · Etienne Garin, MD PHD (1) · Gao-Jun Teng (1) · Jiping Wang, MD, PhD (1) · Marc Peeters (1) · Marc Van den Eynde (1) · Steven J. Cohen, M.D. (1) · Ulrich Keilholz, Prof. Dr. med. (1) · Vincent Donckier, MD, PHD (1)