4 completed, 2 terminated. 3 Phase 2, 2 Phase 3, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Completed 3 |
| Phase 3 | 2 | Terminated 2 |
| Phase 1 | 1 | Completed 1 |
Follow selonsertib: new trials by email Literature Review of selonsertib trials Research Report on selonsertib
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Safety and Efficacy of Selonsertib in Adults With Nonalcoholic Steatohepatitis (NASH) and Bridging (F3) Fibrosis SEL, Placebo to match SEL 6 mg, Placebo to match SEL 18 mg - Nonalcoholic Steatohepatitis | Phase 3 | Terminated | Gilead Sciences | 808 | 2017-02-13 | 2020-06-29 |
| Safety and Efficacy of Selonsertib in Adults With Compensated Cirrhosis Due to Nonalcoholic Steatohepatitis (NASH) SEL, Placebo to match SEL 6 mg, Placebo to match SEL 18 mg - Nonalcoholic Steatohepatitis | Phase 3 | Terminated | Gilead Sciences | 883 | 2017-01-30 | 2020-05-07 |
| Selonsertib in Combination With Prednisolone Versus Prednisolone Alone in Participants With Severe Alcoholic Hepatitis (AH) Selonsertib, Prednisolone, Placebo - Alcoholic Hepatitis (AH) | Phase 2 | Completed | Gilead Sciences | 104 | 2016-09-01 | 2019-02-06 |
| Study to Evaluate the Pharmacokinetics of Selonsertib in Participants With Normal and Impaired Hepatic Function Selonsertib - Diabetic Kidney Disease | Phase 1 | Completed | Gilead Sciences | 52 | 2015-08-18 | 2021-01-27 |
| Selonsertib in Adults With Pulmonary Arterial Hypertension Placebo, Selonsertib - Pulmonary Arterial Hypertension | Phase 2 | Completed | Gilead Sciences | 151 | 2014-11-01 | 2019-04-10 |
| Efficacy, Safety, and Tolerability of Selonsertib (GS-4997) in Participants With Diabetic Kidney Disease Selonsertib, Placebo to match selonsertib - Diabetic Kidney Disease | Phase 2 | Completed | Gilead Sciences | 334 | 2014-06-01 | 2019-11-05 |
Diabetic Nephropathies (2) · Non-alcoholic Fatty Liver Disease (2) · Fibrosis (1) · Hepatitis, Alcoholic (1) · Jaundice (1) · Pulmonary Arterial Hypertension (1)
Gilead Sciences (6)
United States (6) · Canada (5) · France (4) · United Kingdom (4) · Austria (3) · Belgium (3) · Germany (3) · Italy (3) · Spain (3) · Switzerland (3) · Australia (2) · Hong Kong (2) · India (2) · Israel (2) · Japan (2)
PMID 30639779, PMID 30779990, PMID 31271665, PMID 32147362, PMID 33307033, PMID 36750244, PMID 26180085, PMID 31506292, PMID 34425071
2016 (3), 2014 (1), 2015 (1)