4 completed, 1 not yet recruiting, 1 terminated. 3 Phase 1, 3 Phase 2, 1 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Completed 3 |
| Phase 2 | 3 | Completed 1, Not yet recruiting 1, Terminated 1 |
| Phase 3 | 1 | Completed 1 |
Follow Rifapentine (RPT): new trials by email Literature Review of Rifapentine (RPT) trials Research Report on Rifapentine (RPT)
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Short-Course Anti-tuberculosis Regimens for Mild Spinal Tuberculosis Rifampin, Isoniazid, Rifapentine (RPT) - Mild Spinal Tuberculosis | Phase 2 | Not yet recruiting | Shandong University | 300 | 2025-04-05 | 2025-04-08 |
| Drug-Drug Interactions Between Rifapentine and Dolutegravir in HIV/LTBI Co-Infected Individuals Dolutegravir (DTG), Isoniazid (INH), Rifapentine (RPT) - HIV Infection, LTBI | Phase 2 | Terminated | National Institute of Allergy and Infectious Diseases (NIAID) | 37 | 2021-02-27 | 2024-09-19 |
| Doravirine, Rifapentine and Isoniazid Interaction Doravirine (DOR), Rifapentine (RPT), Isoniazid (INH) - Latent Tuberculosis, Human Immunodeficiency Virus | Phase 1 | Completed | Walter K. Kraft | 11 | 2019-04-22 | 2020-03-27 |
| Evaluating PK, Tolerability, and Safety of Rifapentine and Isoniazid in Pregnant and Postpartum Women Rifapentine (RPT), Isoniazid (INH), Pyridoxine (vitamin B6) - Tuberculosis | Phase 1 / Phase 2 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 50 | 2017-03-13 | 2021-11-04 |
| Evaluating the Pharmacokinetics of High-Dose Rifapentine When Given as a Single Dose or in Divided Doses to Healthy Adults Rifapentine (RPT) - Tuberculosis | Phase 1 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 44 | 2012-06-01 | 2021-11-05 |
| Brief Rifapentine-Isoniazid Evaluation for TB Prevention (BRIEF TB) Rifapentine (RPT), Isoniazid (INH), Pyridoxine (Vitamin B6) - Tuberculosis, HIV Infections | Phase 3 | Completed | National Institute of Allergy and Infectious Diseases (NIAID) | 3000 | 2012-05-23 | 2021-11-04 |
Tuberculosis (3) · HIV Infections (2) · Acquired Immunodeficiency Syndrome (1) · Latent Tuberculosis (1)
National Institute of Allergy and Infectious Diseases (NIAID) (4) · Shandong University (1) · Walter K. Kraft (1)
United States (4) · Haiti (3) · Malawi (3) · Thailand (3) · Zimbabwe (3) · Botswana (2) · Kenya (2) · South Africa (2) · Brazil (1) · China (1) · Peru (1)
Anthony Podany, PharmD (1) · Jyoti S. Mathad, MD, MSc (1) · Richard E. Chaisson, MD (1) · Susan Swindells, MBBS (1) · Walter K Kraft, MD (1) · Wei Zhao, Ph.D (1)
PMID 25824215, PMID 26082504, PMID 30865794, PMID 31414121, PMID 32815870, PMID 34323955, PMID 35943252, PMID 38568956, PMID 41487489