4 completed, 2 terminated, 1 recruiting. 5 Phase 3, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 5 | Completed 4, Recruiting 1 |
| Phase 2 | 1 | Terminated 1 |
Follow rFVIII: new trials by email Literature Review of rFVIII trials Research Report on rFVIII
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Study of Recombinant Von Willebrand Factor (rVWF) in Chinese Participants With Von Willebrand Disease (vWD) VONVENDI, ADVATE - Von Willebrand Disease (VWD) | Phase 3 | Recruiting | Takeda | 20 | 2025-10-13 | 2026-01-08 |
| A Study of Recombinant Von Willebrand Factor (rVWF) in Pediatric and Adult Participants With Severe Von Willebrand Disease (VWD) rVWF, rFVIII - Von Willebrand Disease (VWD) | Phase 3 | Completed | Baxalta now part of Shire | 38 | 2019-04-01 | 2025-09-03 |
| rVWF IN PROPHYLAXIS von Willebrand factor (Recombinant), Antihemophilic Factor (Recombinant) - Von Willebrand Disease | Phase 3 | Completed | Takeda | 29 | 2017-11-16 | 2021-08-06 |
| A Study of Recombinant Von Willebrand Factor (rVWF) With or Without ADVATE in Children With Severe Von Willebrand Disease (VWD) Vonicog alfa, Antihemophilic Factor (Recombinant) - Von Willebrand Disease | Phase 3 | Completed | Baxalta now part of Shire | 47 | 2017-11-06 | 2026-05-15 |
| Weight-based Dosing in Hemophilia A rFVIII - Hemophilia | Phase 2 | Terminated | Craig Seaman | 30 | 2015-09-01 | 2020-09-25 |
| Fc factOrs and Real-World hemophiliA Patient-ReporteD Outcomes rFVIIIFc, rFIXFc, non-Fc FVIII replacement products - Hemophilia A, Hemophilia B | Terminated | Bioverativ Therapeutics Inc. | 3 | 2015-07-01 | 2020-12-19 | |
| Pharmacokinetics, Safety and Efficacy of Recombinant Von Willebrand Factor (rVWF) in the Treatment of Bleeding Episodes in Von Willebrand Disease (VWD) Recombinant von Willebrand factor (rVWF), Placebo, Recombinant factor VIIII (rFVIII) - Von Willebrand Disease | Phase 3 | Completed | Baxalta now part of Shire | 49 | 2011-11-01 | 2021-05-19 |
von Willebrand Diseases (5) · Hemophilia A (2) · Hemophilia B (1)
Baxalta now part of Shire (3) · Takeda (2) · Bioverativ Therapeutics Inc. (1) · Craig Seaman (1)
United States (6) · Germany (4) · Italy (4) · Netherlands (4) · Russia (4) · Spain (4) · Austria (3) · France (3) · Turkey (Türkiye) (3) · Belgium (2) · Canada (2) · United Kingdom (2) · Australia (1) · Bulgaria (1) · China (1)
PMID 26239086, PMID 35439298, PMID 36861346
2016 (2), 2018 (1), 2023 (1)