6 completed, 1 terminated. 5 Phase 1, 5 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 5 | Completed 4, Terminated 1 |
| Phase 2 | 5 | Completed 4, Terminated 1 |
Follow PX-866: new trials by email Literature Review of PX-866 trials Research Report on PX-866
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Study of PX-866 and Vemurafenib in Patients With Advanced Melanoma PX-866, vemurafenib - Advanced BRAF-mutant Cancers | Phase 1 / Phase 2 | Terminated | Cascadian Therapeutics Inc. | 24 | 2012-08-01 | 2018-05-16 |
| A Phase II Study of PX-866 in Patients With Recurrent or Metastatic Castration Resistant Prostate Cancer PX-866 - Prostate Cancer | Phase 2 | Completed | NCIC Clinical Trials Group | 68 | 2011-09-09 | 2023-08-22 |
| Study of the Pharmacokinetics and Pharmacodynamics of Crystalline PX-866 Tablets and Amorphous PX-866 Capsules in Healthy Volunteers PX-866 - Healthy Volunteer | Phase 1 | Completed | Cascadian Therapeutics Inc. | 39 | 2011-07-01 | 2018-05-17 |
| A Study of PX-866 in Patients With Glioblastoma Multiforme at Time of First Relapse or Progression PX-866 - Glioblastoma | Phase 2 | Completed | NCIC Clinical Trials Group | 34 | 2011-04-01 | 2023-08-22 |
| Phase 1 and 2 Study of PX-866 and Cetuximab PX-866 (SCCHN), Cetuximab (SCCHN), PX-866 (CRC) - Incurable Metastatic Colorectal Carcinoma, Incurable Progressive, Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck | Phase 1 / Phase 2 | Completed | Cascadian Therapeutics Inc. | 178 | 2010-12-01 | 2018-05-16 |
| Study of PX-866 and Docetaxel in Solid Tumors Docetaxel, PX-866 - Non Small Cell Lung Cancer (NSCLC), Squamous Cell Carcinoma of the Head and Neck (SCCHN) | Phase 1 / Phase 2 | Completed | Cascadian Therapeutics Inc. | 223 | 2010-09-01 | 2018-05-16 |
| Phase I Trial of Oral PX-866 PX-866 - Advanced Solid Tumors | Phase 1 | Completed | Cascadian Therapeutics Inc. | 90 | 2008-06-01 | 2018-05-17 |
Hereditary Sensory and Autonomic Neuropathies (3) · Carcinoma (1) · Carcinoma, Non-Small-Cell Lung (1) · Carcinoma, Squamous Cell (1) · Colorectal Neoplasms (1) · Glioblastoma (1) · Neoplasms (1) · Prostatic Neoplasms (1) · Recurrence (1) · Squamous Cell Carcinoma of Head and Neck (1)
Cascadian Therapeutics Inc. (5) · NCIC Clinical Trials Group (2)
United States (5) · Canada (4)
Diana Hausman, MD (1) · Howard Quint, MD (1) · Kim Chi (1) · Marshall Pitz (1) · Sebastien Hotte (1)