5 completed, 1 not yet recruiting, 1 unknown. 3 Phase 2, 2 Phase 3, 2 Phase 4, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Completed 2, Not yet recruiting 1 |
| Phase 3 | 2 | Completed 1, Not yet recruiting 1 |
| Phase 4 | 2 | Completed 1, Unknown 1 |
| Phase 1 | 1 | Completed 1 |
Follow Primaquine Phosphate: new trials by email Literature Review of Primaquine Phosphate trials Research Report on Primaquine Phosphate
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Postpartum 8-aminoquinoline Breast Milk Study Daily primaquine (0.5 mg/kg per day) for 14 days given with food food and water, Daily primaquine 1 mg/kg per day for 7 days given with food and water, Single-dose tafenoquine given with food and water to prevent gastrointestinal discomfort - Drug Pharmacokinetics in Healthy Volunteers | Phase 2 / Phase 3 | Not yet recruiting | Curtin University | 60 | 2026-04-01 | 2026-03-18 |
| Gametocytocidal and Transmission-blocking Efficacy of ASAQ and ALAQ With or Without PQ in Mali Artesunate-amodiaquine combination, Primaquine Phosphate, Artemether-lumefantrine - Malaria,Falciparum | Phase 2 | Completed | London School of Hygiene and Tropical Medicine | 100 | 2022-10-17 | 2024-10-01 |
| Gametocytocidal and Transmission-blocking Efficacy of PQ in Combination With AL and TQ in Combination With SPAQ in Mali Artemether-lumefantrine, Primaquine Phosphate, Sulphadoxine-pyrimethamine with amodiaquine - Malaria,Falciparum | Phase 2 | Completed | London School of Hygiene and Tropical Medicine | 80 | 2021-10-12 | 2022-01-18 |
| Metabolism and Pharmacokinetics of Primaquine Enantiomers in Human Volunteers Receiving a Seven Day Dose Regimen RPQ, SPQ, Primaquine Phosphate - Malaria, Glucose 6 Phosphate Dehydrogenase Deficiency | Phase 1 | Completed | University of Mississippi, Oxford | 36 | 2018-08-17 | 2019-05-14 |
| Targeted Active Case Detection Among High Risk Populations in Southern Lao Peoples Democratic Republic Standard RDT and HS-RDT, Artemether-lumefantrine, Primaquine Phosphate - Plasmodium Falciparum Malaria | Phase 4 | Completed | University of California, San Francisco | 39968 | 2017-11-28 | 2021-02-23 |
| Evaluation of the Gametocytocidal Efficacy and Safety of Primaquine in Uncomplicated Falciparum Malaria in Uganda Primaquine - Falciparum Malaria | Phase 3 | Completed | London School of Hygiene and Tropical Medicine | 468 | 2011-12-01 | 2013-06-12 |
| Investigation of Short Course, High Dose Primaquine Treatment for Liver Stages of Plasmodium Vivax Infection Primaquine - Plasmodium Vivax | Phase 4 | Unknown | Papua New Guinea Institute of Medical Research | 150 | 2010-06-01 | 2015-10-14 |
Malaria, Falciparum (4) · Malaria (2) · Malaria, Vivax (2) · Breast Feeding (1) · Glucosephosphate Dehydrogenase Deficiency (1) · Hemolysis (1)
London School of Hygiene and Tropical Medicine (3) · Curtin University (1) · Papua New Guinea Institute of Medical Research (1) · University of California, San Francisco (1) · University of Mississippi, Oxford (1)
Mali (2) · Papua New Guinea (2) · Laos (1) · Uganda (1) · United States (1)
Alassane Dicko (2) · Adam Bennett, MA, PhD (1) · Alice C Eziefula, MBBS MCRP MRCPath (1) · Brioni Moore, PhD (1) · Inoni Betuela, MD, PhD (1) · Ivo Mueller, PhD (1) · J Kevin Baird, PhD (1) · Larry Walker, Phd (1) · Timothy ME Davis, FRAC, PhD (1)
PMID 24239324, PMID 27197604, PMID 32118199, PMID 37269941, PMID 38705163, PMID 39701119