6 completed, 2 unknown, 1 not yet recruiting, 1 recruiting. 3 Phase 2, 2 Phase 3, 2 Phase 4, 1 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 3 | Completed 3 |
| Phase 3 | 2 | Completed 1, Unknown 1 |
| Phase 4 | 2 | Completed 1, Unknown 1 |
| Not applicable | 1 | Recruiting 1 |
| Phase 1 | 1 | Completed 1 |
Follow polyene phosphatidylcholine: new trials by email Literature Review of polyene phosphatidylcholine trials Research Report on polyene phosphatidylcholine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| A Real World Study of Polyene Phosphatidylcholine Injection for the Prevention and Treatment of DILI in Patients With Malignant Hematological Diseases polyene phosphatidylcholine - Drug-Induced Liver Injury | Not yet recruiting | Institute of Hematology & Blood Diseases Hospital, China | 1000 | 2026-03-31 | 2026-03-17 | |
| Glucocorticoids for Acute Drug Induced Liver Injury With Hyperbilirubinemia Methylprednisolone, Magnesium isoglycyrrhizinate, Glutathione - Drug Induced Liver Injury | Not applicable | Recruiting | General Hospital of Shenyang Military Region | 232 | 2025-06-24 | 2025-12-18 |
| Evaluate the Efficacy and Safety of AYP-101 for the Reduction of Submental Fat in Chin Area Polyene Phosphatidylcholine, Matching placebo of AYP-101 - Healthy | Phase 3 | Completed | AMIpharm Co., Ltd. | 252 | 2024-03-26 | 2026-01-22 |
| Evaluate Pharmacokinetic/Pharmacodynamic and Safety/Tolerability of AYP-101 in Healthy Subjects Polyene Phosphatidylcholine - Healthy Subjects, Submental Fat | Phase 1 | Completed | AMIpharm Co., Ltd. | 26 | 2022-08-10 | 2026-01-22 |
| Determine the Dosing Interval and Optimal Dose of AYP-101 for the Reduction of Submental Fat in Chin Area Polyene Phosphatidylcholine, Placebo - Moderate or Severe Submental Fullness | Phase 2 | Completed | AMIpharm Co., Ltd. | 96 | 2022-03-02 | 2023-08-15 |
| The Multi-Center, Randomized, Double-blind, Positive Controlled Clinical Trial of Bicyclol in the Treatment of Acute DILI bicyclol, 25mg/ tablet, polyene phosphatidylcholine capsules, 228mg/ particle. - Drug-Induced Acute Liver Injury | Phase 3 | Unknown | Drug Induced Liver Disease Study Group | 360 | 2021-12-20 | 2022-08-04 |
| Efficacy and Safety of Polyene Phosphatidylcholine in Treatment of Patients With Acute Drug-induced Liver Injury Polyene phosphatidylcholine injection 930 mg QD, Magnesium Isoglycyrrhizinate injection 200 mg QD - Acute Drug Induced Liver Injury | Phase 4 | Completed | Sichuan Haisco Pharmaceutical Group Co., Ltd | 73 | 2020-04-04 | 2020-11-24 |
| Evaluate the Efficacy and Safety of Polyene Phosphatidylcholine Injection (AYP-101) for the Reduction of Submental Fat Polyene phosphatidylcholine injection, Placebo - Moderate or Severe Submental Fullness | Phase 2 | Completed | AMIpharm Co., Ltd. | 143 | 2019-07-01 | 2023-08-15 |
| The Multi Center, Randomized, Double-blind, Positive Controlled Study of Bicyclol in the Treatment of Acute DILI bicyclol tablet 25mg, bicyclol tablet 50mg, polyene phosphatidylcholine capsule 456mg - Drug-Induced Acute Liver Injury | Phase 2 | Completed | Drug Induced Liver Disease Study Group | 244 | 2017-08-18 | 2020-04-28 |
| Study of Effects and Safety Between Adefovir Dipivoxil Plus Polyene Phosphatidylcholine Versus Adefovir Dipivoxil Alone in Chronic Hepatitis B Patients Adefovir Dipivoxil and polyene phosphatidylcholine, Adefovir Dipivoxil - Chronic Hepatitis B | Phase 4 | Unknown | Jun Cheng | 300 | 2011-09-01 | 2011-09-19 |
Chemical and Drug Induced Liver Injury (5) · Lymphoma, Follicular (2) · Hepatitis B, Chronic (1) · Hyperbilirubinemia (1) · Liver Failure (1)
AMIpharm Co., Ltd. (4) · Drug Induced Liver Disease Study Group (2) · General Hospital of Shenyang Military Region (1) · Institute of Hematology & Blood Diseases Hospital, China (1) · Jun Cheng (1) · Sichuan Haisco Pharmaceutical Group Co., Ltd (1)
China (5) · South Korea (4)
Chengwei Chen (2) · Yimin Mao (2) · Beomjoon Kim, MD (1) · Dae Hyeon Lew, MD,PhD (1) · Fengmei Wang (1) · Jae Yong Chung, M.D.,Ph.D (1) · Lu Zhou (1) · Qing Ye (1) · Weifen Xie (1) · Xin Zeng (1) · Xingshun Qi (1) · Yanjing Gao (1) · Yimin Mao, M.D. (1)
PMID 22806342, PMID 27426618, PMID 35567757, PMID 38402364, PMID 39183394, PMID 39732703, PMID 42080196