5 completed, 1 terminated. 3 Phase 1, 3 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Completed 3 |
| Phase 2 | 3 | Completed 2, Terminated 1 |
Follow ontuxizumab: new trials by email Literature Review of ontuxizumab trials Research Report on ontuxizumab
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| MORAb-004 in Treating Young Patients With Recurrent or Refractory Solid Tumors or Lymphoma anti-endosialin/TEM1 monoclonal antibody MORAb-004, pharmacological study, laboratory biomarker analysis - Adult Nasal Type Extranodal NK/T-cell Lymphoma, Anaplastic Large Cell Lymphoma | Phase 1 | Completed | Morphotek | 27 | 2013-11-01 | 2016-01-08 |
| A Phase 1 Study of MORAb-004 in Patients With Solid Tumor (Study: MORAb-004-J081-103) MORAb-004 - Solid Tumor | Phase 1 | Completed | Eisai Co., Ltd. | 46 | 2012-12-01 | 2016-11-10 |
| Sarcoma Study of MORAb-004 Utilization: Research and Clinical Evaluation MORAb-004, Gemcitabine, Docetaxel - Metastatic Soft Tissue Sarcoma | Phase 2 | Completed | Morphotek | 209 | 2012-08-07 | 2019-08-21 |
| Morphotek Investigation in Colorectal Cancer: Research of MORAb-004 (MICRO) MORAb-004, Placebo, Best supportive care - Metastatic Colorectal Cancer, Colorectal Cancer | Phase 2 | Terminated | Morphotek | 154 | 2012-03-27 | 2022-05-06 |
| Efficacy Study of Pharmacokinetic(PK)/Pharmacodynamic(PD) Relationship of Monotherapy MORAb-004 in Metastatic Melanoma MORAb-004 (monoclonal antibody) - Metastatic Melanoma | Phase 2 | Completed | Eisai Inc. | 76 | 2011-05-16 | 2021-09-01 |
| A Study of of MORAb-004 in Subjects With Solid Tumors MORAb-004 (monoclonal antibody to TEM1) - Solid Tumor | Phase 1 | Completed | Morphotek | 80 | 2009-03-01 | 2014-07-16 |
Burkitt Lymphoma (1) · Colorectal Neoplasms (1) · Dendritic Cell Sarcoma, Interdigitating (1) · Hodgkin Disease (1) · Immunoblastic Lymphadenopathy (1) · Intraocular Lymphoma (1) · Leukemia, Hairy Cell (1) · Leukemia, Large Granular Lymphocytic (1) · Leukemia, Lymphocytic, Chronic, B-Cell (1) · Lymphoma, B-Cell, Marginal Zone (1) · Lymphoma, Extranodal NK-T-Cell (1) · Lymphoma, Follicular (1) · Lymphoma, Large B-Cell, Diffuse (1) · Lymphoma, Large-Cell, Anaplastic (1) · Lymphoma, Large-Cell, Immunoblastic (1)
Morphotek (4) · Eisai Co., Ltd. (1) · Eisai Inc. (1)
United States (5) · Australia (2) · Belgium (1) · France (1) · Germany (1) · Italy (1) · Japan (1) · Netherlands (1) · United Kingdom (1)
Robin Norris (1) · Ryo Nakajima (1) · Susan Weil, MD (1)
PMID 29292843, PMID 30623276, PMID 31034598
U01CA097452 (1)