molibresib: Clinical Trials

7 trials of molibresib, newest first

ClinicalTrials Daily  ·  Areas  ·  Conditions  ·  Drugs  ·  Sponsors  ·  

2 completed, 2 terminated, 2 withdrawn, 1 no longer available. 5 Phase 1, 2 Phase 2.

By phase and status

PhaseTrialsStatus
Phase 15Terminated 2, Withdrawn 2, Completed 1
Phase 22Completed 1, Withdrawn 1

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Trials newest first · largest first

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

TrialPhaseStatusSponsorEnrollmentStartUpdated
Testing of the Addition of a New Anti-cancer Drug, Molibresib, to Chemotherapy Treatment (Etoposide and Cisplatin) for Patients With NUT Carcinoma
Cisplatin, Etoposide, Etoposide Phosphate - Metastatic NUT Carcinoma, Unresectable NUT Carcinoma
Phase 1 / Phase 2WithdrawnNational Cancer Institute (NCI)2020-09-182020-09-28
Testing a New Anti-cancer Drug Combination, Entinostat and GSK525762C, for Advanced and Refractory Solid Tumors and Lymphomas
Entinostat, Molibresib - Advanced Lymphoma, Advanced Malignant Solid Neoplasm
Phase 1WithdrawnNational Cancer Institute (NCI)2020-09-182020-09-28
Dose Escalation and Expansion Study of GSK525762 in Combination With Fulvestrant in Participants With Hormone Receptor-positive (HR+)/Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Advanced or Metastatic Breast Cancer
GSK525762, Placebo, Fulvestrant - Neoplasms
Phase 1TerminatedGlaxoSmithKline1242019-09-262024-08-29
Dose Escalation and Dose Expansion Study of GSK525762 in Combination With Androgen Deprivation Therapy in Participants With Castrate-resistant Prostate Cancer
GSK525762, Abiraterone, Enzalutamide - Solid Tumours
Phase 1TerminatedGlaxoSmithKline732017-07-182022-08-10
A Dose Escalation Study to Investigate the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD) and Clinical Activity of GSK525762 in Subjects With Relapsed, Refractory Hematologic Malignancies
GSK525762 - Neoplasms
Phase 2CompletedGlaxoSmithKline1112014-05-142024-10-01
A Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of GSK525762 in Subjects With NUT Midline Carcinoma (NMC) and Other Cancers
GSK525762 - Carcinoma, Midline
Phase 1CompletedGlaxoSmithKline1962012-03-282020-03-16
Compassionate Use Individual Request Program for GSK525762 in NUT Midline Carcinoma
molibresib - Solid Tumours
No longer availableGlaxoSmithKline2020-04-13

Conditions studied

Neoplasms (3)  ·  Lymphoma (2)  ·  Multiple Myeloma (2)  ·  Breast Neoplasms (1)  ·  Carcinoma (1)  ·  Leukemia (1)  ·  Leukemia, Myeloid, Acute (1)  ·  Lymphoma, B-Cell (1)  ·  Lymphoma, T-Cell (1)  ·  Myelodysplastic Syndromes (1)  ·  Neuroblastoma (1)  ·  Pancreatic Neoplasms (1)  ·  Small Cell Lung Carcinoma (1)

Sponsors

GlaxoSmithKline (5)  ·  National Cancer Institute (NCI) (2)

Countries

Australia (4)  ·  Spain (4)  ·  United Kingdom (4)  ·  United States (4)  ·  South Korea (3)  ·  France (2)  ·  Canada (1)  ·  Netherlands (1)

Top investigators

Geoffrey I Shapiro (1)  ·  Patricia M LoRusso (1)

Results publications

PMID 24457244, PMID 33955700, PMID 34724226, PMID 36350312

NIH funding

2016 (2), 2014 (1), UM1CA186689 (1), UM1CA186709 (1)