2 completed, 2 terminated, 2 withdrawn, 1 no longer available. 5 Phase 1, 2 Phase 2.
By phase and status
Follow molibresib: new trials by email Literature Review of molibresib trials Research Report on molibresib
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
Testing of the Addition of a New Anti-cancer Drug, Molibresib, to Chemotherapy Treatment (Etoposide and Cisplatin) for Patients With NUT Carcinoma Cisplatin, Etoposide, Etoposide Phosphate - Metastatic NUT Carcinoma, Unresectable NUT Carcinoma | Phase 1 / Phase 2 | Withdrawn | | 2020-09-18 | 2020-09-28 |
Testing a New Anti-cancer Drug Combination, Entinostat and GSK525762C, for Advanced and Refractory Solid Tumors and Lymphomas Entinostat, Molibresib - Advanced Lymphoma, Advanced Malignant Solid Neoplasm | Phase 1 | Withdrawn | | 2020-09-18 | 2020-09-28 |
Dose Escalation and Expansion Study of GSK525762 in Combination With Fulvestrant in Participants With Hormone Receptor-positive (HR+)/Human Epidermal Growth Factor Receptor 2 Negative (HER2-) Advanced or Metastatic Breast Cancer GSK525762, Placebo, Fulvestrant - Neoplasms | Phase 1 | Terminated | 124 | 2019-09-26 | 2024-08-29 |
Dose Escalation and Dose Expansion Study of GSK525762 in Combination With Androgen Deprivation Therapy in Participants With Castrate-resistant Prostate Cancer GSK525762, Abiraterone, Enzalutamide - Solid Tumours | Phase 1 | Terminated | 73 | 2017-07-18 | 2022-08-10 |
A Dose Escalation Study to Investigate the Safety, Pharmacokinetics (PK), Pharmacodynamics (PD) and Clinical Activity of GSK525762 in Subjects With Relapsed, Refractory Hematologic Malignancies GSK525762 - Neoplasms | Phase 2 | Completed | 111 | 2014-05-14 | 2024-10-01 |
A Study to Investigate the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of GSK525762 in Subjects With NUT Midline Carcinoma (NMC) and Other Cancers GSK525762 - Carcinoma, Midline | Phase 1 | Completed | 196 | 2012-03-28 | 2020-03-16 |
Compassionate Use Individual Request Program for GSK525762 in NUT Midline Carcinoma molibresib - Solid Tumours | | No longer available | | | 2020-04-13 |
Conditions studied
Neoplasms (3) · Lymphoma (2) · Multiple Myeloma (2) · Breast Neoplasms (1) · Carcinoma (1) · Leukemia (1) · Leukemia, Myeloid, Acute (1) · Lymphoma, B-Cell (1) · Lymphoma, T-Cell (1) · Myelodysplastic Syndromes (1) · Neuroblastoma (1) · Pancreatic Neoplasms (1) · Small Cell Lung Carcinoma (1)
Sponsors
GlaxoSmithKline (5) · National Cancer Institute (NCI) (2)
Countries
Australia (4) · Spain (4) · United Kingdom (4) · United States (4) · South Korea (3) · France (2) · Canada (1) · Netherlands (1)
Top investigators
Geoffrey I Shapiro (1) · Patricia M LoRusso (1)
Results publications
PMID 24457244, PMID 33955700, PMID 34724226, PMID 36350312
NIH funding
2016 (2), 2014 (1), UM1CA186689 (1), UM1CA186709 (1)