5 completed, 2 terminated. 7 Phase 2.
By phase and status
Follow itepekimab: new trials by email Literature Review of itepekimab trials Research Report on itepekimab
Trials (filtered) newest first · largest first
All 7 trials
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti--IL-33 mAb) in Participants With Chronic Rhinosinusitis Without Nasal Polyps Itepekimab (SAR440340), Placebo, Mometasone furoate nasal spray (MFNS) - Chronic Rhinosinusitis Without Nasal Polyps | Phase 2 | Completed | 66 | 2024-12-16 | 2026-08-25 |
A Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of Itepekimab (Anti-IL-33 mAb) in Participants With Non-cystic Fibrosis Bronchiectasis Itepekimab (SAR440340), Placebo - Bronchiectasis | Phase 2 | Completed | 314 | 2024-02-20 | 2026-10-07 |
Mechanistic Study of the Effect of Itepekimab on Airway Inflammation in Patients With COPD Itepekimab SAR440340 - Chronic Obstructive Pulmonary Disease | Phase 2 | Completed | 49 | 2022-05-19 | 2026-08-31 |
Efficacy, Safety, and Pharmacokinetic Profiles of REGN3500 Administered to Adult Patients With Moderate-to-Severe Atopic Dermatitis REGN3500, REGN3500-Matching Placebo - Atopic Dermatitis | Phase 2 | Terminated | 129 | 2018-11-13 | 2022-06-10 |
Efficacy and Safety of REGN3500 Monotherapy and Combination of REGN3500 Plus Dupilumab in Adult Patients With Moderate-to-Severe Atopic Dermatitis REGN3500, Dupilumab, REGN3500 + Dupilumab Combo - Atopic Dermatitis | Phase 2 | Terminated | 206 | 2018-11-12 | 2021-11-01 |
Proof-of-Concept Study to Assess the Efficacy, Safety and Tolerability of SAR440340 (Anti-IL-33 mAb) in Patients With Moderate-to-severe Chronic Obstructive Pulmonary Disease (COPD) SAR440340, Placebo, Any Inhaled Corticosteroids as prescribed by treating physician as standard of care - Chronic Obstructive Pulmonary Disease | Phase 2 | Completed | 343 | 2018-07-16 | 2022-11-22 |
Evaluation of SAR440340 and as Combination Therapy With Dupilumab in Moderate-to-Severe Asthma Participants SAR440340, Dupilumab, Fluticasone or Fluticasone/salmeterol combination - Asthma | Phase 2 | Completed | 296 | 2018-03-12 | 2022-06-14 |
Conditions studied
Dermatitis, Atopic (2) · Lymphoma, Follicular (2) · Pulmonary Disease, Chronic Obstructive (2) · Asthma (1) · Bronchiectasis (1)
Sponsors
Sanofi (5) · Regeneron Pharmaceuticals (2)
Countries
United States (7) · Poland (6) · Germany (5) · Argentina (4) · Canada (4) · Chile (4) · Spain (4) · Belgium (3) · Czechia (3) · South Korea (3) · Turkey (Türkiye) (3) · United Kingdom (3) · Australia (2) · Brazil (2) · China (2)
Results publications
PMID 39077906, PMID 34302758, PMID 34706171, PMID 36253275
NIH funding
2017 (2), 2018 (2), 2023 (1)