8 completed, 2 recruiting, 1 terminated. 3 Phase 3, 3 Phase 4, 2 Phase 2, 1 Not applicable, 1 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 3 | Completed 2, Recruiting 1 |
| Phase 4 | 3 | Completed 3 |
| Phase 2 | 2 | Completed 1, Recruiting 1 |
| Not applicable | 1 | Completed 1 |
| Phase 1 | 1 | Recruiting 1 |
Follow Fampridine: new trials by email Literature Review of Fampridine trials Research Report on Fampridine
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Preoperative Imatinib and Fampridine in KIT Mutant Gastrointestinal Stromal Tumor Imatinib, Fampridine - Gastrointestinal Stromal Tumors | Phase 1 | Recruiting | University of California, San Diego | 18 | 2026-05-13 | 2026-05-27 |
| 4-aminopyridine Treatment for Nerve Injury 4-Aminopyridine, Placebo - Nerve Injury, Prostate Cancer | Phase 2 / Phase 3 | Recruiting | John Elfar | 70 | 2021-06-05 | 2025-12-17 |
| Muscle Strain in Multiple Sclerosis Patients Measured by Ultrasound Speckle Tracking Technique Fampridine - Multiple Sclerosis | Not applicable | Completed | University of Southern Denmark | 48 | 2018-12-12 | 2022-04-05 |
| Fampridine in MS Patients: A Cognition, Fatigue, Depression and Quality of Life Analysis Fampridine - Multiple Sclerosis | Completed | Genesis Pharma CNS & Specialty | 111 | 2017-03-07 | 2019-02-15 | |
| Fampridine Pregnancy Exposure Registry Fampridine - Multiple Sclerosis, Pregnancy | Terminated | Biogen | 1 | 2015-08-01 | 2016-10-18 | |
| Efficacy and Safety Study of Prolonged-Release Fampridine in Participants With Multiple Sclerosis fampridine, Placebo - Multiple Sclerosis | Phase 3 | Completed | Biogen | 646 | 2014-09-01 | 2017-03-27 |
| A Study of the Effectiveness of Fampridine in Improving Upper Limb Function in MS Fampridine, Placebo - Secondary Progressive Multiple Sclerosis, Primary Progressive Multiple Sclerosis | Phase 4 | Completed | University College Dublin | 64 | 2014-02-21 | 2021-07-09 |
| Short and Long Term Multiple Outcomes in Persons With Multiple Sclerosis Treated by Fampridine. Fampridine - Multiple Sclerosis | Phase 4 | Completed | Centre Hospitalier Universitaire de Besancon | 89 | 2014-02-04 | 2021-02-02 |
| An Observational Study to Collect Information on Safety and to Document the Drug Utilization of Fampyra (BIIB041) When Used In Routine Medical Practice Fampridine - Multiple Sclerosis | Completed | Biogen | 4734 | 2012-04-16 | 2019-06-05 | |
| Open-Label Study to Assess the Effect of Long-Term Prolonged-Release Fampridine (BIIB041) on Quality of Life as Reported by Participants With Multiple Sclerosis Fampridine - Multiple Sclerosis | Phase 4 | Completed | Biogen | 901 | 2012-02-01 | 2017-03-21 |
| Ampyra for Optic Neuritis in Multiple Sclerosis Dalfampridine/Placebo, Placebo/Dalfampridine - Multiple Sclerosis, Optic Neuritis | Phase 2 / Phase 3 | Completed | Washington University School of Medicine | 53 | 2011-05-01 | 2020-01-30 |
Multiple Sclerosis (9) · Erectile Dysfunction (1) · Fatigue (1) · Gastrointestinal Stromal Tumors (1) · Multiple Sclerosis, Chronic Progressive (1) · Optic Neuritis (1) · Prostatic Neoplasms (1) · Sprains and Strains (1)
Biogen (4) · Centre Hospitalier Universitaire de Besancon (1) · Genesis Pharma CNS & Specialty (1) · John Elfar (1) · University College Dublin (1) · University of California, San Diego (1) · University of Southern Denmark (1) · Washington University School of Medicine (1)
France (4) · United States (4) · Netherlands (3) · Czechia (2) · Denmark (2) · Germany (2) · Ireland (2) · Italy (2) · Portugal (2) · United Kingdom (2) · Argentina (1) · Australia (1) · Belgium (1) · Bulgaria (1) · Canada (1)
Christopher McGuigan, MD (1) · Helle H. Nielsen, MD, PhD (1) · John Elfar, MD (1) · Maria Thorning, MSc (1) · Paul Fanta, MD (1) · Rashid Sayyid, MD (1) · Robert T Naismith, MD (1)
PMID 12525714, PMID 14606742, PMID 15147583, PMID 16283615, PMID 16980142, PMID 17895294, PMID 17942508, PMID 18653737, PMID 18951800, PMID 19068404, PMID 1992392, PMID 20594850, PMID 20976768, PMID 21112438, PMID 22315143, PMID 23247892, PMID 23535489, PMID 23791482, PMID 23962697, PMID 24090757, PMID 24378281, PMID 24503204, PMID 25583832, PMID 26041616, PMID 26409700, PMID 26810506, PMID 26843986, PMID 27004639, PMID 30535670, PMID 32634812, PMID 33528792, PMID 34322853, PMID 36436320, PMID 38773595, PMID 8148458, PMID 8664723