2 terminated, 2 unknown, 1 not yet recruiting, 1 recruiting. 4 Phase 2, 2 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Not yet recruiting 1, Recruiting 1, Terminated 1, Unknown 1 |
| Phase 3 | 2 | Recruiting 1, Terminated 1 |
| Phase 4 | 1 | Unknown 1 |
Follow epalrestat: new trials by email Literature Review of epalrestat trials Research Report on epalrestat
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Epalrestat Combined With HAIC, Donafenib and Tislelizumab as First-line Treatment for Patients With Unresectable HCC and Diabetes Epalrestat, Donafenib + Tislelizumab, HAIC - HCC - Hepatocellular Carcinoma, Diabetes | Phase 2 | Not yet recruiting | Haibo Shao | 32 | 2026-10-01 | 2026-09-21 |
| Evaluating a Nitric Oxide Generator, Nebivolol as a Disease Modifier in Patients With Diabetic Neuropathy. Nebivolol+ Standard care arm, Epalrestat + Alpha Lipoic Acid +Standard care, Standard care alone - Diabetic Neuropathy Peripheral | Phase 2 / Phase 3 | Recruiting | St. John's Research Institute | 120 | 2024-11-15 | 2025-02-04 |
| Research of SORD-CMT Natural History and Epalrestat Treatment Epalrestat - Charcot-Marie-Tooth Disease (CMT) | Phase 2 | Unknown | The Third Xiangya Hospital of Central South University | 30 | 2023-04-01 | 2023-04-18 |
| Oral Epalrestat Therapy in Pediatric Subjects With PMM2-CDG Epalrestat, Placebo - Pmm2-CDG, Phosphomannomutase 2 Deficiency | Phase 3 | Terminated | Maggie's Pearl, LLC | 42 | 2022-11-10 | 2025-09-25 |
| Effects of Epalrestat on Peripheral Neuropathy and Central Nervous System in Diabetic Patients Epalrestat,Mecobalamin, Mecobalamin - Diabetes | Phase 4 | Unknown | Xiangya Hospital of Central South University | 72 | 2022-01-01 | 2022-01-11 |
| Evaluation of Epalrestat in Metastatic Triple-negative Breast Cancer Epalrestat - Triple Negative Breast Cancer | Phase 2 | Terminated | Sun Yat-sen University | 12 | 2017-03-01 | 2021-01-29 |
Diabetes Mellitus (2) · Carcinoma, Hepatocellular (1) · Charcot-Marie-Tooth Disease (1) · Congenital disorder of glycosylation type 1A (1) · Triple Negative Breast Neoplasms (1)
Haibo Shao (1) · Maggie's Pearl, LLC (1) · St. John's Research Institute (1) · Sun Yat-sen University (1) · The Third Xiangya Hospital of Central South University (1) · Xiangya Hospital of Central South University (1)
China (3) · India (1) · United States (1)
Eva Morava-Kozicz, MD, PhD (1) · Haibo Shao (1) · Tao Han (1)