4 completed. 4 Phase 3.
| Phase | Trials | Status |
|---|---|---|
| Phase 3 | 4 | Completed 4 |
Follow difelikefalin: new trials by email Literature Review of difelikefalin trials Research Report on difelikefalin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Phase 3 Study of Difelikefalin in Haemodialysis Chinese Adult Subjects With Moderate-to-Severe Pruritus Difelikefalin Injection, Placebo Injection - Uremic Pruritus | Phase 3 | Completed | Vifor Fresenius Medical Care Renal Pharma | 260 | 2023-05-18 | 2025-09-12 |
| CR845-CLIN3105: A Study to Evaluate the Safety and Effectiveness of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus CR845 0.5 mcg/kg - Uremic Pruritus | Phase 3 | Completed | Cara Therapeutics, Inc. | 222 | 2019-05-06 | 2021-10-15 |
| CR845-CLIN3103: A Global Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus CR845 0.5 mcg/kg, Placebo - Uremic Pruritus | Phase 3 | Completed | Cara Therapeutics, Inc. | 473 | 2018-07-17 | 2022-04-26 |
| A Study to Evaluate the Safety and Efficacy of CR845 in Hemodialysis Patients With Moderate-to-Severe Pruritus (KALM-1) CR845 0.5 mcg/kg, Placebo - Uremic Pruritus | Phase 3 | Completed | Cara Therapeutics, Inc. | 378 | 2018-02-20 | 2022-04-26 |
Kidney Failure, Chronic (3) · Pruritus (3) · Renal Insufficiency, Chronic (3)
Cara Therapeutics, Inc. (3) · Vifor Fresenius Medical Care Renal Pharma (1)
United States (3) · Czechia (2) · Hungary (2) · Poland (2) · Australia (1) · Canada (1) · China (1) · Germany (1) · New Zealand (1) · South Korea (1) · Taiwan (1) · United Kingdom (1)
PMID 36039153, PMID 37968132, PMID 39037824, PMID 33283264, PMID 36016762, PMID 31702883, PMID 36185706, PMID 38196014