3 unknown, 2 completed, 2 terminated, 1 active not recruiting. 7 Phase 1, 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 7 | Completed 2, Terminated 2, Unknown 2, Active not recruiting 1 |
| Phase 2 | 4 | Unknown 2, Completed 1, Terminated 1 |
Follow Chlorotoxin: new trials by email Literature Review of Chlorotoxin trials Research Report on Chlorotoxin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| CAR T Cells in Patients With MMP2+ Recurrent or Progressive Glioblastoma CHM-1101 CAR-T cells - Glioblastoma Multiforme of Brain | Phase 1 | Terminated | Chimeric Therapeutics | 1 | 2023-06-06 | 2026-06-29 |
| Chimeric Antigen Receptor (CAR) T Cells With a Chlorotoxin Tumor-Targeting Domain for the Treatment of MMP2+ Recurrent or Progressive Glioblastoma Chlorotoxin (EQ)-CD28-CD3zeta-CD19t-expressing CAR T-lymphocytes (via ICT delivery), Chlorotoxin (EQ)-CD28-CD3zeta-CD19t-expressing CAR T-lymphocytes (via ICT/ICV dual delivery) - Recurrent Glioblastoma, Recurrent Malignant Glioma | Phase 1 | Active not recruiting | City of Hope Medical Center | 19 | 2020-05-26 | 2026-10-22 |
| A Study of 131I-TM601 in Adults With Recurrent Malignant Glioma 131I-TM601 - Malignant Glioma, Glioblastoma Multiforme | Phase 1 / Phase 2 | Unknown | TransMolecular | 64 | 2008-08-01 | 2009-07-17 |
| Safety and Dose-Finding Study of TM-601 in Adults With Recurrent Malignant Glioma TM-601 - Malignant Glioma, Glioblastoma Multiforme | Phase 1 | Unknown | TransMolecular | 36 | 2008-02-01 | 2009-07-17 |
| 131-I-TM-601 Study in Adults With Solid Tumors 131-I-TM-601 (chlorotoxin) - Breast Cancer, Non-Small Cell Lung Cancer | Phase 1 | Completed | TransMolecular | 60 | 2006-08-01 | 2009-03-31 |
| 131-I-TM-601 Study in Adults With Recurrent High-Grade Glioma 131-I-TM-601, 131I-TM601 - Malignant Glioma, Glioblastoma Multiforme | Phase 2 | Unknown | TransMolecular | 66 | 2004-11-01 | 2009-04-03 |
| Safety and Tolerability Study of 131I-TM-601 to Treat Adult Patients With Recurrent Glioma. 131I-TM-601 - Glioma, Brain Neoplasm | Phase 1 / Phase 2 | Completed | TransMolecular | 18 | 2002-06-01 | 2009-03-31 |
| A Safety and Efficacy Study of Intravenous 131I-TM601 in Adult Patients With Malignant Melanoma 131I-TM601 - Melanoma, Malignant Melanoma | Phase 1 / Phase 2 | Terminated | TransMolecular | 58 | 2009-05-11 |
Glioma (6) · Glioblastoma (5) · Brain Neoplasms (4) · Astrocytoma (3) · Melanoma (2) · Oligodendroglioma (2) · Breast Neoplasms (1) · Carcinoma, Non-Small-Cell Lung (1) · Colorectal Neoplasms (1) · Gliosarcoma (1) · Pancreatic Neoplasms (1)
TransMolecular (6) · Chimeric Therapeutics (1) · City of Hope Medical Center (1)
United States (8)
John Fiveash, MD (3) · Jay-Jiguang Zhu, MD (2) · Neil Senzer, MD (2) · Sean Grimm, MD (2) · Steven Chmura, MD (2) · Thomas Gribbin, MD (2) · Adam Mamelak, MD (1) · Anna Pavlick, DO (1) · Antonio Omuro, MD (1) · Behnam Badie (1) · Burt Nabors, MD (1) · David Schiff, MD (1) · Diana M Hablitz, MSNCRNP (1) · Edward Pan, MD (1) · Gerry Linette, MD (1)