3 recruiting, 2 active not recruiting, 1 terminated. 6 Phase 3.
By phase and status
Follow Cemdisiran: new trials by email Literature Review of Cemdisiran trials Research Report on Cemdisiran
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All 6 trials
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
A Study to Evaluate How Pozelimab + Cemdisiran Combination Therapy Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Whose Current Treatment is Not Working Efficiently Pozelimab, Cemdisiran - Paroxysmal Nocturnal Hemoglobinuria | Phase 3 | Recruiting | 35 | 2026-06-11 | 2026-08-05 |
A Study Investigating Subcutaneously Administered Pozelimab in Combination With Cemdisiran or Cemdisiran Alone in Adult Participants With Geographic Atrophy Pozelimab, Cemdisiran, Placebo - Age-related Macular Degeneration (AMD), Geographic Atrophy (GA) | Phase 3 | Recruiting | 975 | 2024-10-30 | 2026-10-13 |
A Study in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) to Evaluate How Safe Long-term Treatment With Pozelimab + Cemdisiran Combination Therapy is and How Well it Works Pozelimab, Cemdisiran - Paroxysmal Nocturnal Hemoglobinuria | Phase 3 | Recruiting | 202 | 2023-03-07 | 2026-09-28 |
Efficacy and Safety of the Combination of Pozelimab and Cemdisiran Versus Continued Eculizumab or Ravulizumab Treatment in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria Cemdisiran, Eculizumab, Pozelimab - Paroxysmal Nocturnal Hemoglobinuria | Phase 3 | Terminated | 3 | 2022-10-06 | 2025-04-08 |
A Study to Evaluate How Safe Pozelimab + Cemdisiran Combination Therapy is and How Well it Works in Adult Patients With Paroxysmal Nocturnal Hemoglobinuria (PNH) Who Have Not Recently Received or Have Not Received Complement Inhibitor Treatment Ravulizumab, Pozelimab, Cemdisiran - Paroxysmal Nocturnal Hemoglobinuria | Phase 3 | Active not recruiting | 202 | 2022-08-01 | 2026-04-30 |
A Study to Test How Safe Pozelimab and Cemdisiran Combination Therapy and Cemdisiran Alone Are and How Well They Work in Adult Patients With Generalized Myasthenia Gravis Pozelimab + Cemdisiran, Cemdisiran, Placebo - Generalized Myasthenia Gravis | Phase 3 | Active not recruiting | 288 | 2021-12-14 | 2026-10-28 |
Conditions studied
Hemoglobinuria, Paroxysmal (4) · Geographic Atrophy (1) · Macular Degeneration (1) · Myasthenia Gravis (1)
Sponsors
Regeneron Pharmaceuticals (6)
Countries
Canada (5) · Italy (5) · Poland (5) · Spain (5) · Brazil (4) · South Korea (4) · Turkey (Türkiye) (4) · United Kingdom (4) · United States (4) · Hungary (3) · India (3) · Japan (3) · Taiwan (3) · China (2) · Colombia (2)
Results publications
PMID 42030965
NIH funding
2023 (4)