11 completed, 2 unknown, 1 terminated, 1 withdrawn. 13 Phase 2, 6 Phase 1, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 13 | Completed 10, Unknown 2, Terminated 1 |
| Phase 1 | 6 | Completed 6 |
| Not applicable | 1 | Withdrawn 1 |
Follow Avotermin: new trials by email Literature Review of Avotermin trials Research Report on Avotermin
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Juvista in the Non-surgical Improvement of Existing Scars Juvista, Placebo - Scars | Not applicable | Withdrawn | Renovo | 40 | 2009-01-01 | 2010-03-09 |
| Safety of Juvista When Administered Following Excision of Ear Lobe Keloids Avotermin, placebo - Keloid | Phase 1 / Phase 2 | Completed | Renovo | 10 | 2008-07-01 | 2010-03-09 |
| Trial of Juvista (Avotermin) Following Removal of Ear Lobe Keloid Scars Avotermin - Keloid | Phase 1 / Phase 2 | Completed | Renovo | 20 | 2007-06-01 | 2009-09-16 |
| Juvista (Avotermin) in Scars Following Varicose Vein Removal Avotermin - Varicose Veins, Cicatrix | Phase 2 | Completed | Renovo | 156 | 2006-11-01 | 2010-03-09 |
| Juvista (Avotermin) in Breast Reduction Surgery Scars Avotermin - Mammaplasty, Cicatrix | Phase 2 | Terminated | Renovo | 39 | 2006-10-01 | 2009-01-13 |
| Scar-Improvement Efficacy and Safety of a Single Intradermal Injection of Avotermin (Juvista) Administered Following Full-Thickness Skin Incisions Avotermin, Placebo - Cicatrix | Phase 2 | Completed | Renovo | 39 | 2006-07-01 | 2008-03-04 |
| Juvista (Avotermin) in the Prevention or Improvement of Scar Appearance Following Scar Revision Surgery. Avotermin - Cicatrix | Phase 2 | Unknown | Renovo | 60 | 2006-05-01 | 2009-02-04 |
| RN1001(Avotermin) in Scar Improvement Following Breast Augmentation Avotermin - Mammaplasty, Cicatrix | Phase 2 | Completed | Renovo | 63 | 2004-12-01 | 2008-08-14 |
| A Trial to Investigate Scar Improvement Efficacy of RN1001 (Avotermin) After Head and Neck Naevi Excision Avotermin - Nevus, Cicatrix | Phase 2 | Unknown | Renovo | 239 | 2004-04-01 | 2008-04-11 |
| Anti-Scarring Efficacy and Safety of Intradermal Juvista (Avotermin) in Healthy Males Juvista (avotermin) plus placebo, standard-care (within-subject controls) - Cicatrix | Phase 2 | Completed | Renovo | 71 | 2003-10-01 | 2008-01-15 |
| Investigation of the Accelerated Healing and Anti-scarring Potential of Avotermin (Juvista) in Split Skin Graft Donor Sites Avotermin, Placebo - Cicatrix, Wound Healing | Phase 2 | Completed | Renovo | 102 | 2003-10-01 | 2009-09-25 |
| Safety and Efficacy Study of Avotermin (Juvista) in Female Subjects Avotermin, Placebo - Cicatrix, Wound Healing | Phase 1 / Phase 2 | Completed | Renovo | 35 | 2003-04-01 | 2009-09-25 |
| Efficacy and Safety of Intradermal RN1001 (Avotermin) in Elderly Subjects. Avotermin, Placebo - Cicatrix | Phase 1 / Phase 2 | Completed | Renovo | 42 | 2002-09-01 | 2009-02-19 |
| Investigation of the Safety, Dosing Frequency and Anti-Scarring Potential of Two Concentrations of Intradermal Avotermin (Juvista) Avotermin, Placebo - Cicatrix, Wound Healing | Phase 1 / Phase 2 | Completed | Renovo | 43 | 2002-02-01 | 2009-09-16 |
| Safety Study of Repeated, Escalating Doses of Intradermal Avotermin (Juvista) Avotermin, Placebo (vehicle) - Cicatrix, Wound Healing | Phase 1 | Completed | Renovo | 55 | 2001-05-01 | 2009-09-16 |
Cicatrix (13) · Arrhythmogenic Right Ventricular Dysplasia, Familial, 1 (2) · Keloid (2) · Nevus (1) · Varicose Veins (1)
Renovo (15)
United Kingdom (13) · United States (2) · Belgium (1) · Latvia (1) · Lithuania (1)
Jonathan Duncan (3) · Jeremy Bond (2) · Michael J Davies (2) · D A McGrouther, FRCS MD (1) · David Whitby (1) · James Bush (1) · James Bush, MBChB (1) · James Dr Bush, MBChB MRCS (1) · Jim Bush, MB ChB (1) · Jim Bush, MBChB (1) · Jonathan Duncan, BS BCh (1) · Leroy Young, MD (1) · Peter McCollum, MB MCh FRCS (1) · Philip Gilbert, FDSRCS FRCS (1) · V V Young, MD (1)