5 completed, 1 active not recruiting. 5 Phase 2, 1 Not applicable.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 5 | Completed 4, Active not recruiting 1 |
| Not applicable | 1 | Completed 1 |
Follow afimoxifene: new trials by email Literature Review of afimoxifene trials Research Report on afimoxifene
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Topical Afimoxifene in Treating Patients With Breast Cancer Who Have Undergone Radiation Therapy on One Breast Afimoxifene, Core Biopsy, Questionnaire Administration - Cancer Survivor, Ductal Breast Carcinoma In Situ | Phase 2 | Active not recruiting | Northwestern University | 156 | 2020-02-17 | 2025-10-09 |
| Afimoxifene in Reducing the Risk of Breast Cancer in Women With Mammographically Dense Breast Afimoxifene, Laboratory Biomarker Analysis, Placebo - Mammographically Dense Breast | Phase 2 | Completed | M.D. Anderson Cancer Center | 194 | 2018-01-30 | 2024-02-22 |
| Testing an Active Form of Tamoxifen (4-hydroxytamoxifen) Delivered Through Breast Skin to Control Ductal Carcinoma in Situ (DCIS) of the Breast Afimoxifene, Laboratory Biomarker Analysis, Placebo - Ductal Breast Carcinoma In Situ, Estrogen Receptor Positive | Phase 2 | Completed | Northwestern University | 100 | 2017-05-31 | 2024-12-18 |
| 4-Hydroxytamoxifen or Tamoxifen Citrate in Treating Women With Newly Diagnosed Ductal Breast Carcinoma in Situ oral placebo, afimoxifene, tamoxifen citrate - Ductal Breast Carcinoma in Situ, Estrogen Receptor-positive Breast Cancer | Phase 2 | Completed | Northwestern University | 27 | 2009-12-01 | 2015-07-21 |
| Effect of 4-Hydroxytamoxifen Gel on Breast Density, Salivary Sex Steroids, and Quality of Life in Premenopausal Women 4-hydroxytamoxifen, breast imaging study, radiomammography - Breast Cancer | Not applicable | Completed | Northwestern University | 2003-04-01 | 2012-05-30 | |
| Study of Afimoxifene Gel to Treat Cyclic Mastalgia in Premenopausal Women Afimoxifene (0.057%) in hydroalcoholic gel - Cyclic Breast Pain, Cyclic Mastalgia | Phase 2 | Completed | ASCEND Therapeutics | 146 | 2003-03-01 | 2023-08-16 |
Carcinoma, Intraductal, Noninfiltrating (3) · Breast Neoplasms (1) · Mastodynia (1)
Northwestern University (4) · ASCEND Therapeutics (1) · M.D. Anderson Cancer Center (1)
United States (5)
Banu Arun, MD (1) · Robert E Mansel, MD (1) · Seema A Khan, M.D. (1) · Seema A. Khan, MD (1) · Seema Khan (1) · Seema Khan, MD (1)
P30CA060553 (3), N01CN00034 (1), N01CN00035 (1), N01CN35157 (1)