4 completed. 4 Phase 1, 1 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 4 | Completed 4 |
| Phase 2 | 1 | Completed 1 |
Follow Unresectable Malignant Solid Neoplasm: new trials by email Literature Review of Unresectable Malignant Solid Neoplasm trials Research Report on Unresectable Malignant Solid Neoplasm
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| ALRN-6924 and Paclitaxel in Treating Patients With Advanced, Metastatic, or Unresectable Solid Tumors MDM2/MDMX Inhibitor ALRN-6924, Paclitaxel - Advanced Malignant Solid Neoplasm, Anatomic Stage III Breast Cancer AJCC v8 | Phase 1 | Completed | M.D. Anderson Cancer Center | 28 | 2019-01-24 | 2026-03-16 |
| Olaparib and Onalespib in Treating Patients With Solid Tumors That Are Metastatic or Cannot Be Removed by Surgery or Recurrent Ovarian, Fallopian Tube, Primary Peritoneal, or Triple-Negative Breast Cancer Olaparib, Onalespib - Metastatic High Grade Fallopian Tube Serous Adenocarcinoma, Metastatic Malignant Solid Neoplasm | Phase 1 | Completed | National Cancer Institute (NCI) | 28 | 2017-05-19 | 2023-04-26 |
| Testing the Addition of the Anti-Cancer Drug Talazoparib to the Combination of Carboplatin and Paclitaxel for the Treatment of Advanced Cancer Carboplatin, Paclitaxel, Talazoparib - Advanced Malignant Solid Neoplasm, Metastatic Malignant Solid Neoplasm | Phase 1 | Completed | National Cancer Institute (NCI) | 43 | 2015-09-08 | 2023-08-29 |
| Uprosertib, Dabrafenib, and Trametinib in Treating Patients With Stage IIIC-IV Cancer Biopsy, Biospecimen Collection, Computed Tomography - Hematopoietic and Lymphoid Cell Neoplasm, Locally Advanced Malignant Solid Neoplasm | Phase 1 / Phase 2 | Completed | National Cancer Institute (NCI) | 27 | 2013-10-08 | 2025-01-14 |
Neoplasm Metastasis (4) · Breast Neoplasms (2) · Hematologic Neoplasms (1) · Melanoma (1) · Triple Negative Breast Neoplasms (1)
Neoplasms (4) · Neoplastic Processes (4) · Pathologic Processes (4) · Pathological Conditions, Signs and Symptoms (4) · Neoplasms by Site (3) · Skin Diseases (3) · Skin and Connective Tissue Diseases (3) · Breast Diseases (2) · Hematologic Diseases (1) · Hemic and Lymphatic Diseases (1) · Neoplasms by Histologic Type (1) · Neoplasms, Germ Cell and Embryonal (1) · Neoplasms, Nerve Tissue (1) · Neuroectodermal Tumors (1) · Neuroendocrine Tumors (1)
Paclitaxel (2) · Taxes (2) · (2,4-dihydroxy-5-isopropylphenyl)-(5-(4-methylpiperazin-1-ylmethyl)-1,3-dihydroisoindol-2-yl)methanone (1) · Biopsy (1) · Carboplatin (1) · GSK2141795 (1) · Magnetic Resonance Spectroscopy (1) · Specimen Handling (1) · dabrafenib (1) · olaparib (1) · talazoparib (1) · trametinib (1)
National Cancer Institute (NCI) (3) · M.D. Anderson Cancer Center (1)
United States (4)
Antoni Ribas (1) · Ecaterina E Dumbrava (1) · Kari B Wisinski (1) · Panagiotis A Konstantinopoulos (1)
PMID 35396812, PMID 37823909, PMID 38261444
U10CA032102 (1), U10CA180830 (1), U10CA180888 (1), UM1CA186709 (1), UM1CA186716 (1)