16 completed, 4 unknown, 3 active not recruiting. 19 Not applicable, 2 Phase 3, 1 Phase 4.
| Phase | Trials | Status |
|---|---|---|
| Not applicable | 19 | Completed 12, Unknown 4, Active not recruiting 3 |
| Phase 3 | 2 | Completed 2 |
| Phase 4 | 1 | Completed 1 |
Follow Nasolabial Fold: new trials by email Literature Review of Nasolabial Fold trials Research Report on Nasolabial Fold
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Hyaluronic Acid Crosslinking Clinical Study Hyaluronic Acid Dermal Fillers - Facial Aging, Skin Aging | Not applicable | Active not recruiting | Antony de Paula Barbosa | 20 | 2026-03-01 | 2026-08-04 |
| Open, Non-comparative Study to Evaluate the Effectiveness and Safety of the Medical Device KOS® L in Correcting Moderate or Severe Nasolabial Folds KOS® L - Nasolabial Fold | Not applicable | Completed | Quantum Beauty Kozmetik | 34 | 2025-06-16 | 2025-08-21 |
| Post Market Clinical Follow up Evaluating the Performance and Safety of Juläine(TM) on Nasolabial Fold Wrinkles Juläine - Nasolabial Fold | Not applicable | Active not recruiting | Nordberg Medical AB | 59 | 2024-07-24 | 2026-10-02 |
| Tissue Repositioning Versus Tissue Support in Thread Lifting for Nasolabial Fold Correction: A Randomized, Evaluator-Blinded, Parallel-Group Controlled Trial predominantly tissue-repositioning thread lifting, predominantly tissue-support thread-lifting - Nasolabial Fold | Not applicable | Completed | Beijing Tsinghua Chang Gung Hospital | 182 | 2022-06-21 | 2026-10-16 |
| Histology Study of Biostimulatory Activity of Injectable Poly-L-Lactic Acid (Sculptra Aesthetic) Sculptra Aesthetic, Placebo - Nasolabial Fold, Facial Wrinkles | Not applicable | Unknown | Sadick Research Group | 10 | 2021-08-09 | 2021-08-11 |
| RHA® 4 NLF Cannula Split-face injection of RHA® 4 with a cannula into a single NLF., Split-face injection of RHA® 4 with a needle (TSK 27G x ½") into the contralateral NLF. - Wrinkle, Nasolabial Fold | Not applicable | Completed | Teoxane SA | 50 | 2021-03-15 | 2023-03-09 |
| LifeSprout Lumina™ Study in the Treatment of Nasolabial Folds Study Product, Active Control - Nasolabial Fold | Not applicable | Active not recruiting | LifeSprout, Inc. | 118 | 2021-03-02 | 2022-09-10 |
| Preliminary Safety and Effectiveness of SMI-01 as a Tissue Filler SMI-01 - Nasolabial Fold, Cheek Augmentation | Not applicable | Completed | Sofregen Medical, Inc. | 21 | 2020-11-10 | 2024-05-31 |
| Evaluate the Safety and Effectiveness of Sodium Hyaluronate When Used for the Correction of Nasolabial Folds HA+Lidocaine, HA - Dermal Filler, Hyaluronic Acid | Not applicable | Completed | SciVision Biotech Inc. | 130 | 2020-08-20 | 2022-02-25 |
| To Evaluate the Efficacy and Safety of Injection With HARA as Compared to Restylane® Lidocaine in Temporary Correction of Nasolabial Folds HARA Filler(Hyaluronic acid Filler), Restylane® Lidocaine - Nasolabial FOLD | Not applicable | Unknown | Huons Co., Ltd. | 67 | 2019-04-23 | 2020-01-13 |
| Evaluation of Collagen Dermal Filler With Lidocaine for the Correction of Nasolabial Folds Sunmax FULLSGEN with Lidocaine - Nasolabial Fold | Not applicable | Unknown | National Taiwan University Hospital | 240 | 2019-03-01 | 2019-03-18 |
| The Effect of Platelet-rich Fibrin Matrix on Skin Rejuvenation PRFM injection, Saline injection - Skin Rejuvenation, Skin Quality | Not applicable | Completed | New York Medical College | 30 | 2018-09-03 | 2019-10-22 |
| A Study to Evaluate the Performance and Safety of GP0045 for Correction of Moderate to Severe Nasolabial Folds GP0045, Comparator - Nasolabial Fold, Safety | Not applicable | Completed | Galderma R&D | 20 | 2017-10-02 | 2022-08-26 |
| Pain and Safety of Restylane Perlane With and Without Lidocaine for Correction of Moderate and Severe Nasolabial Folds Restylane Perlane Lidocaine, Restylane Perlane - Nasolabial Fold | Not applicable | Completed | Galderma R&D | 70 | 2017-09-21 | 2022-08-26 |
| Pain and Safety of Restylane With and Without Lidocaine for Correction of Moderate and Severe Nasolabial Folds Restylane Lidocaine, Restylane - Nasolabial Fold | Not applicable | Completed | Galderma R&D | 70 | 2017-02-08 | 2023-06-01 |
| China Post-Market Clinical Follow-up of FACILLE® Dermal Filler, Hyaluronic Acid | Completed | SciVision Biotech Inc. | 1552 | 2016-12-14 | 2022-03-24 | |
| A Clinical Study to Evaluate the Efficacy and Safety of the Injection With UNIVELO Sub-Q, as Compared to Restylane® Sub-Q, in the Temporary Correction of the Nasolabial Fold UNIVELO Sub-Q 2mL, Restylane Sub-Q 2mL - Nasolabial Fold | Not applicable | Completed | Jetema Co., Ltd. | 65 | 2016-02-23 | 2025-09-08 |
| A Safety and Efficacy Study of JUVÉDERM® VOLIFT® With Lidocaine and Restylane® for Nasolabial Folds in Chinese Adults JUVÉDERM® VOLIFT® with Lidocaine, Restylane® - Nasolabial Fold | Not applicable | Completed | Allergan | 175 | 2016-01-25 | 2017-08-30 |
| Patient Satisfaction Study of Combined Facial Treatment With BOTOX® Cosmetic, JUVÉDERM® and LATISSE® (HARMONY Study) onabotulinumtoxinA, bimatoprost ophthalmic solution 0.03%, JUVÉDERM® ULTRA XC - Facial Rhytides, Crow's Feet Lines | Phase 4 | Completed | Allergan | 116 | 2014-06-30 | 2019-01-09 |
| Efficacy and Safety Evaluation Study of Neuramis® Deep Lidocaine in Correction of Nasolabial Fold Neuramis® Deep Lidocaine, Restylane® PERLANE-L - Nasolabial Fold | Phase 3 | Completed | Medy-Tox | 60 | 2013-06-01 | 2016-04-26 |
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