3 active not recruiting, 3 recruiting, 2 completed, 1 not yet recruiting. 7 Phase 2, 5 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 7 | Recruiting 3, Completed 2, Active not recruiting 1, Not yet recruiting 1 |
| Phase 1 | 5 | Active not recruiting 2, Recruiting 2, Terminated 1 |
Follow Metastatic Skin Squamous Cell Carcinoma: new trials by email Literature Review of Metastatic Skin Squamous Cell Carcinoma trials Research Report on Metastatic Skin Squamous Cell Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Low Dose, Reduced Frequency Nivolumab for the Treatment of Unresectable or Metastatic Cancer, AFFORD IO Trial Biospecimen Collection, Computed Tomography, Magnetic Resonance Imaging - Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 | Phase 2 | Not yet recruiting | Fred Hutchinson Cancer Center | 50 | 2026-12-01 | 2026-09-17 |
| Treatment With Amivantamab and Hyaluronidase or Cetuximab for Advanced Skin Cancer in People With a Weakened Immune System Amivantamab and Recombinant Human Hyaluronidase, Biospecimen Collection, Cetuximab - Locally Recurrent Skin Squamous Cell Carcinoma, Metastatic Skin Squamous Cell Carcinoma | Phase 2 | Recruiting | National Cancer Institute (NCI) | 86 | 2026-03-23 | 2026-10-15 |
| Immunotherapy in Combination With Prednisone and Sirolimus for Kidney Transplant Recipients With Unresectable or Metastatic Skin Cancer Biopsy Procedure, Biospecimen Collection, Computed Tomography - Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 | Phase 1 / Phase 2 | Recruiting | National Cancer Institute (NCI) | 16 | 2024-07-24 | 2026-10-14 |
| Personalized Neoantigen Peptide-Based Vaccine in Combination With Pembrolizumab for Treatment of Advanced Solid Tumors Cyclophosphamide, Neoantigen Peptide Vaccine, Pembrolizumab - Anatomic Stage III Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | Phase 1 / Phase 2 | Recruiting | Mayo Clinic | 138 | 2022-03-31 | 2026-08-20 |
| Cemiplimab Before and After Surgery for the Treatment of High Risk Cutaneous Squamous Cell Cancer Cemiplimab, Radiation Therapy, Therapeutic Conventional Surgery - Metastatic Skin Squamous Cell Carcinoma, Recurrent Skin Squamous Cell Carcinoma | Phase 1 | Active not recruiting | Emory University | 14 | 2020-05-15 | 2026-09-14 |
| Talimogene Laherparepvec and Panitumumab for the Treatment of Locally Advanced or Metastatic Squamous Cell Carcinoma of the Skin Panitumumab, Talimogene Laherparepvec - Locally Advanced Skin Squamous Cell Carcinoma, Metastatic Skin Squamous Cell Carcinoma | Phase 1 | Terminated | Rutgers, The State University of New Jersey | 5 | 2020-01-31 | 2026-01-23 |
| Tacrolimus, Nivolumab, and Ipilimumab in Treating Kidney Transplant Recipients With Selected Unresectable or Metastatic Cancers Ipilimumab, Nivolumab, Prednisone - Clinical Stage III Cutaneous Melanoma AJCC v8, Clinical Stage III Cutaneous Merkel Cell Carcinoma AJCC v8 | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 12 | 2019-11-08 | 2026-10-14 |
| Cobimetinib and Atezolizumab in Treating Participants With Advanced or Refractory Rare Tumors Atezolizumab, Cobimetinib - Skin Squamous Cell Carcinoma, Appendix Adenocarcinoma | Phase 2 | Completed | M.D. Anderson Cancer Center | 49 | 2017-04-07 | 2025-05-28 |
| Pembrolizumab in Treating Patients With Rare Tumors That Cannot Be Removed by Surgery or Are Metastatic Laboratory Biomarker Analysis, Pembrolizumab, Questionnaire Administration - Advanced Malignant Solid Neoplasm, Carcinoma of Unknown Primary | Phase 2 | Active not recruiting | M.D. Anderson Cancer Center | 157 | 2016-08-15 | 2026-07-17 |
| Erlotinib in Treating Patients With Recurrent or Metastatic Skin Squamous Cell Carcinoma Erlotinib - Metastatic Skin Squamous Cell Carcinoma, Recurrent Skin Squamous Cell Carcinoma | Phase 2 | Completed | M.D. Anderson Cancer Center | 42 | 2011-03-10 | 2020-06-11 |
Carcinoma, Merkel Cell (4) · Melanoma (4) · Neoplasm Metastasis (4) · Carcinoma, Basal Cell (3) · Carcinoma, Renal Cell (3) · Carcinoma, Non-Small-Cell Lung (2) · Carcinoma, Transitional Cell (2) · Lung Neoplasms (2) · Squamous Cell Carcinoma of Head and Neck (2) · Uterine Cervical Neoplasms (2) · Adenocarcinoma, Mucinous (1) · Adrenal Cortex Neoplasms (1) · Carcinoma, Hepatocellular (1) · Carcinoma, Lobular (1) · Carcinoma, Small Cell (1)
Adenocarcinoma (6) · Carcinoma (6) · Neoplasms by Histologic Type (6) · Neoplasms, Glandular and Epithelial (6) · Neoplasms (5) · Neoplasms by Site (5) · Neoplasms, Germ Cell and Embryonal (5) · Neoplasms, Nerve Tissue (5) · Neuroectodermal Tumors (5) · Neuroendocrine Tumors (5) · Carcinoma, Neuroendocrine (4) · DNA Virus Infections (4) · Infections (4) · Neoplastic Processes (4) · Nevi and Melanomas (4)
Magnetic Resonance Spectroscopy (4) · Specimen Handling (4) · Nivolumab (3) · Biopsy (2) · CTLA-4 Antigen (2) · Ipilimumab (2) · Prednisone (2) · deltacortene (2) · pembrolizumab (2) · prednylidene (2) · (225)Ac-DOTA-c(RGDyK) (1) · Cetuximab (1) · Colony-Stimulating Factors (1) · Cyclophosphamide (1) · Erlotinib Hydrochloride (1)
M.D. Anderson Cancer Center (3) · National Cancer Institute (NCI) (3) · Emory University (1) · Fred Hutchinson Cancer Center (1) · Mayo Clinic (1) · Rutgers, The State University of New Jersey (1)
United States (9) · Uganda (1)
Evan J Lipson (2) · Adam C Berger, MD, FACS (1) · Aung Naing (1) · Bonnie Glisson (1) · Kanwal P Raghav (1) · Michael Lowe, MD (1) · Paul L Swiecicki (1) · Shailender Bhatia, MD (1) · Yanyan Lou, MD, PhD (1)
PMID 29579331, PMID 31533818, PMID 32188704, PMID 32303619, PMID 32503950, PMID 32534809, PMID 33415580, PMID 33427689, PMID 33491277, PMID 33770291, PMID 34241781, PMID 34725215, PMID 35618285, PMID 35999229, PMID 36821617, PMID 37568622, PMID 38252910, PMID 40212844, PMID 41143139, PMID 42342409
UM1CA186691 (2), P30CA016672 (1), P30CA072720 (1), P30CA138292 (1), U10CA180888 (1)