Malignant Primary Gliomas: Clinical Trials

2 recruiting. 2 Phase 1, 2 Phase 2.

By phase and status

Phase	Trials	Status
Phase 1	2	Recruiting 2
Phase 2	2	Recruiting 2

Follow Malignant Primary Gliomas: new trials by email Literature Review of Malignant Primary Gliomas trials Research Report on Malignant Primary Gliomas

Trials (filtered) newest first · largest first

All 2 trials

Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.

Trial	Phase	Status	Sponsor	Enrollment	Start	Updated
5G-PEARL: Paxalisib in Malignant Brain Tumours Paxalisib, Temozolomide capsule - Malignant Primary Gliomas, Glioblastoma Multiforme (GBM)	Phase 1 / Phase 2	Recruiting	Institute of Cancer Research, United Kingdom	64	2026-01-19	2026-02-05
5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours Avutometinib, Defactinib, Temozolomide - Glioblastoma Multiforme (GBM), Glioblastoma Multiform (Grade IV Astrocytoma)	Phase 1 / Phase 2	Recruiting	Institute of Cancer Research, United Kingdom	182	2024-11-15	2026-01-21

Narrower conditions

Glioblastoma (2)

Broader conditions

Astrocytoma (2)  ·  Glioma (2)  ·  Neoplasms (2)  ·  Neoplasms by Histologic Type (2)  ·  Neoplasms, Germ Cell and Embryonal (2)  ·  Neoplasms, Glandular and Epithelial (2)  ·  Neoplasms, Nerve Tissue (2)  ·  Neoplasms, Neuroepithelial (2)  ·  Neuroectodermal Tumors (2)

Interventions

Temozolomide (2)  ·  GDC-0084 (1)  ·  defactinib (1)

Sponsors

Institute of Cancer Research, United Kingdom (2)

Countries

United Kingdom (2)

Top investigators

Juanita Lopez, MD, PhD (2)