2 recruiting, 1 active not recruiting. 3 Phase 1, 2 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 1 | 3 | Recruiting 2, Active not recruiting 1 |
| Phase 2 | 2 | Recruiting 2 |
Follow Malignant Primary Gliomas: new trials by email Literature Review of Malignant Primary Gliomas trials Research Report on Malignant Primary Gliomas
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| 5G-PEARL: Paxalisib in Malignant Brain Tumours Paxalisib, Temozolomide capsule - Malignant Primary Gliomas, Glioblastoma Multiforme (GBM) | Phase 1 / Phase 2 | Recruiting | Institute of Cancer Research, United Kingdom | 64 | 2026-01-19 | 2026-02-05 |
| 5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours Avutometinib, Defactinib, Temozolomide - Glioblastoma Multiforme (GBM), Glioblastoma Multiform (Grade IV Astrocytoma) | Phase 1 / Phase 2 | Recruiting | Institute of Cancer Research, United Kingdom | 182 | 2024-11-15 | 2026-01-21 |
| 5G-EMERALD: Amivantamab in Malignant Brain Tumours Amivantamab - Malignant Primary Gliomas, Glioblastoma Multiform (Grade IV Astrocytoma) | Phase 1 | Active not recruiting | Institute of Cancer Research, United Kingdom | 12 | 2024-10-09 | 2026-08-17 |
Glioblastoma (3)
Astrocytoma (3) · Glioma (3) · Neoplasms (3) · Neoplasms by Histologic Type (3) · Neoplasms, Germ Cell and Embryonal (3) · Neoplasms, Glandular and Epithelial (3) · Neoplasms, Nerve Tissue (3) · Neoplasms, Neuroepithelial (3) · Neuroectodermal Tumors (3)
Temozolomide (2) · GDC-0084 (1) · amivantamab (1) · defactinib (1)
Institute of Cancer Research, United Kingdom (3)
United Kingdom (3)