9 recruiting, 2 active not recruiting, 1 suspended, 1 terminated. 5 Phase 2, 4 Not applicable, 3 Phase 3, 2 Phase 1, 1 Early Phase 1.
Follow HER2-Negative Breast Carcinoma: new trials by email Literature Review of HER2-Negative Breast Carcinoma trials Research Report on HER2-Negative Breast Carcinoma
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Testing Whether Hormone Therapy With Ribociclib is as Effective as Chemotherapy Followed by Hormone Therapy With Ribociclib for the Treatment of High Anatomic Stage Breast Cancer With Low Recurrence Risk, The RxFINE-Low Trial Anastrozole, Biospecimen Collection, Bone Scan - Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage IIIA Breast Cancer AJCC v8 | Phase 3 | Recruiting | National Cancer Institute (NCI) | 1978 | 2026-08-10 | 2026-11-04 |
| Circulating Tumor DNA Based Minimal Residual Disease Detection for Patients With Early-Stage Breast Cancer Biospecimen Collection, Electronic Health Record Review, Survey Administration - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Not applicable | Withdrawn | City of Hope Medical Center | 2026-05-12 | 2026-06-25 | |
| Preoperative Chemotherapy, Pembrolizumab and Low or High Dose RADiation in an Expansion Cohort of Node(+), Triple Negative Breast Cancer Neoadjuvant Pembrolizumab, low dose neoadjuvant boost, High dose neoadjuvant boost - Breast Cancer, Triple Negative Breast Cancer (TNBC) | Phase 2 | Recruiting | UNC Lineberger Comprehensive Cancer Center | 32 | 2026-03-17 | 2026-04-27 |
| Testing Low Dose Tamoxifen for Invasive Breast Cancer, LoTam Trial Anastrozole, Letrozole, Exemestane - Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage 1 Breast Cancer AJCC v8 | Phase 3 | Suspended | Alliance for Clinical Trials in Oncology | 1556 | 2025-02-19 | 2026-09-02 |
| Acutherapy to Prevent Aromatase Inhibitor-Associated Arthralgias in Non-Hispanic Black Postmenopausal Women With Early-Stage Breast Cancer Acupressure Therapy, Acupuncture Therapy, Aromatase Inhibition Therapy - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Not applicable | Recruiting | Emory University | 150 | 2024-12-12 | 2026-01-29 |
| Turkey Tail Mushroom for Treating Post-Menopausal Women With HER2-Negative ER-Positive Breast Cancer Undergoing Surgery Coriolus Versicolor Extract, Questionnaire Administration - Estrogen Receptor-Positive Breast Carcinoma, HER2-Negative Breast Carcinoma | Phase 2 | Recruiting | Mayo Clinic | 40 | 2024-10-25 | 2026-10-16 |
| Dose-Reduced Docetaxel With Cyclophosphamide for the Treatment of Vulnerable Older Women With Stage I-III HER2 Negative Breast Cancer, the DOROTHY Trial Cyclophosphamide, Docetaxel, Medical Chart Review - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Phase 2 | Recruiting | City of Hope Medical Center | 174 | 2024-09-16 | 2026-11-04 |
| Gemcitabine and Ex Vivo Expanded Allogenic Universal Donor, TGFβi Natural Killer (NK) Cells With or Without Naxitamab (Danyelza) for the Treatment of Patients With Metastatic, GD2 Expressing, HER2 Negative Breast Cancer Biospecimen Collection, Computed Tomography, Gemcitabine - Anatomic Stage IV Breast Cancer AJCC v8, HER2-Negative Breast Carcinoma | Phase 1 / Phase 2 | Recruiting | Margaret Gatti-Mays | 42 | 2024-04-02 | 2026-07-23 |
| Adding an Immunotherapy Drug, MEDI4736 (Durvalumab), to the Usual Chemotherapy Treatment (Paclitaxel, Cyclophosphamide, and Doxorubicin) for Stage II-III Breast Cancer Biospecimen Collection, Cyclophosphamide, Doxorubicin - Anatomic Stage II Breast Cancer AJCC v8, Anatomic Stage III Breast Cancer AJCC v8 | Phase 3 | Recruiting | National Cancer Institute (NCI) | 3680 | 2023-11-27 | 2026-11-03 |
| Evaluation of a Once Per Day Regimen of Accelerated Partial Breast Irradiation for Improved Breast Appearance in Pts w/Low Risk, Hormone Responsive Brst Ca Accelerated Partial Breast Irradiation - Anatomic Stage 0 Breast Cancer AJCC v8, Anatomic Stage IA Breast Cancer AJCC v8 | Phase 2 | Active not recruiting | City of Hope Medical Center | 48 | 2023-09-29 | 2026-06-29 |
| A Feasibility Trial of a Web Based App Intervention in Hormone Positive Breast Cancer Patients to Improve Adherence to Endocrine Therapy Best Practice, Internet-Based Intervention, Questionnaire Administration - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Not applicable | Terminated | Emory University | 21 | 2023-03-21 | 2026-04-17 |
| Feasibility Study of Biobehavioral Stress Reduction Intervention in Patients With Triple Negative Breast Cancer Biospecimen Collection, Medical Chart Review, Stress Management Therapy - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Not applicable | Recruiting | Ohio State University Comprehensive Cancer Center | 40 | 2022-12-14 | 2026-06-29 |
| Letrozole With and Without Simvastatin for the Treatment of Stage I-III Hormone Receptor Positive, HER2 Negative Breast Cancer Letrozole, Simvastatin - Anatomic Stage I Breast Cancer AJCC v8, Anatomic Stage II Breast Cancer AJCC v8 | Early Phase 1 | Recruiting | Emory University | 40 | 2022-09-02 | 2026-07-17 |
| Testing the Addition of an Anti-cancer Drug, Berzosertib, to the Usual Treatment (Radiation Therapy) for Chemotherapy-Resistant Triple-Negative and Estrogen and/or Progesterone Receptor Positive, HER2 Negative Breast Cancer Berzosertib, Biospecimen Collection, Quality-of-Life Assessment - Bilateral Breast Carcinoma, HER2-Negative Breast Carcinoma | Phase 1 | Active not recruiting | National Cancer Institute (NCI) | 42 | 2020-09-24 | 2026-07-31 |
Triple Negative Breast Neoplasms (4) · Breast Carcinoma In Situ (2) · Breast Neoplasms (2) · Carcinoma, Intraductal, Noninfiltrating (1)
Breast Diseases (6) · Neoplasms (6) · Neoplasms by Site (6) · Skin Diseases (6) · Skin and Connective Tissue Diseases (6) · Breast Neoplasms (4) · Carcinoma (2) · Carcinoma in Situ (2) · Neoplasms by Histologic Type (2) · Neoplasms, Glandular and Epithelial (2) · Adenocarcinoma (1) · Neoplasms, Ductal, Lobular, and Medullary (1)
Specimen Handling (6) · Letrozole (3) · Magnetic Resonance Spectroscopy (3) · Anastrozole (2) · Cyclophosphamide (2) · exemestane (2) · Absorptiometry, Photon (1) · Acupressure (1) · Acupuncture Therapy (1) · Aromatase Inhibitors (1) · Disulfides (1) · Docetaxel (1) · Doxorubicin (1) · Drug Therapy (1) · Gemcitabine (1)
City of Hope Medical Center (3) · Emory University (3) · National Cancer Institute (NCI) (3) · Alliance for Clinical Trials in Oncology (1) · Margaret Gatti-Mays (1) · Mayo Clinic (1) · Ohio State University Comprehensive Cancer Center (1) · UNC Lineberger Comprehensive Cancer Center (1)
United States (14) · Puerto Rico (3)
Jose G Bazan (2) · Brenda J. Ernst, MD (1) · Dana Casey, MD (1) · Demetria Smith-Graziani, MD,MPH (1) · Erin F Cobain (1) · Jane L. Meisel, MD (1) · Margaret E Gatti-Mays, MD MPH (1) · Nancy Chan (1) · Robert W Mutter (1) · Ruth L. Sacks, MD (1) · Samilia Obeng-Gyasi, MD, MPH (1) · Thanh Nga E Doan, MD (1)
P30CA033572 (3), P30CA138292 (3), R01CA274254 (1), U10CA180820 (1), U10CA180888 (1), UM1CA186686 (1), UM1CA186709 (1)