7 completed, 3 recruiting, 2 terminated. 12 Phase 2, 4 Phase 1.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 12 | Completed 7, Recruiting 3, Terminated 2 |
| Phase 1 | 4 | Completed 3, Terminated 1 |
Follow DCIS: new trials by email Literature Review of DCIS trials Research Report on DCIS
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Ultra Hypo-fractionated Adjuvant Whole Breast Radiation Therapy With Simultaneous Integrated Boost for Early-Stage Breast Cancer (H-ASSIST) Breast Radiotherapy - Breast Cancer, Early-stage Breast Cancer | Phase 2 | Recruiting | UNC Lineberger Comprehensive Cancer Center | 90 | 2025-02-19 | 2026-09-03 |
| LS301-IT in Partial Mastectomy and Sentinel Lymph Node Biopsy (SLNB) for DCIS or Stage I-II Primary Invasive Breast Cancer LS301-IT 0.025 mg/kg, LS301-IT 0.05 mg/kg, LS301-IT 0.075 mg/kg - Breast Cancer, DCIS | Phase 1 / Phase 2 | Completed | Integro Theranostics | 22 | 2023-07-14 | 2026-05-20 |
| Real-Time MRI-Guided 3-Fraction Accelerated Partial Breast Irradiation in Early Breast Cancer MRIdian Radiation Treatment Unit - Breast Cancer, DCIS | Phase 2 | Recruiting | University of Wisconsin, Madison | 30 | 2022-05-16 | 2026-06-11 |
| Genotype and Phenotype Guided Supplementation of TAMoxifen Standard Therapy With ENDOXifen in Breast Cancer Patients (Z)-Endoxifen supplementation according to genotype, (Z)-Endoxifen supplementation according to plasma levels - Breast Cancer, DCIS | Phase 2 | Completed | Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF) | 356 | 2019-09-10 | 2021-09-17 |
| Study of 3-Day Partial Breast Radiation Therapy in Women With Breast Cancer Accelerated Partial Breast Irradiation - Invasive Ductal Breast Carcinoma, Invasive Ductal Carcinoma, Breast | Phase 2 | Recruiting | Memorial Sloan Kettering Cancer Center | 280 | 2019-08-30 | 2026-09-21 |
| Preoperative Palbociclib in Patients With DCIS of the Breast That Are Candidates for Surgery Palbociclib - DCIS | Phase 2 | Terminated | Georgetown University | 17 | 2018-10-08 | 2025-09-26 |
| Trial of Radiation Fractionation Schedules for Once-a-Day Accelerated Partial Breast Irradiation APBI: 30 Gy, APBI: 27.5 Gy - Breast Cancer, DCIS | Phase 2 | Completed | Ontario Clinical Oncology Group (OCOG) | 280 | 2016-05-01 | 2023-08-14 |
| CyberKnife Stereotactic Accelerated Partial Breast Irradiation (SAPBI) CK Stereotactic Accelerated Partial Breast Irradiation - Breast Cancer, DCIS | Phase 1 / Phase 2 | Terminated | Georgetown University | 2 | 2015-02-01 | 2018-04-13 |
| Study of the Efficacy of Chloroquine in the Treatment of Ductal Carcinoma in Situ (The PINC Trial) Chloroquine Standard Dose (500mg/week), Chloroquine Low Dose (250mg/week), Breast Biopsy - Carcinoma, Intraductal, Noninfiltrating, DCIS | Phase 1 / Phase 2 | Completed | Inova Health Care Services | 12 | 2009-12-01 | 2021-06-29 |
| DC Vaccine for Patients With Ductal Carcinoma In Situ HER-2 Pulsed Dendritic cell Vaccine - Breast Cancer, DCIS | Phase 1 / Phase 2 | Completed | Abramson Cancer Center at Penn Medicine | 58 | 2009-07-01 | 2020-04-10 |
| Chemoprevention Trial - Anastrozole in Ductal Carcinoma In Situ (DCIS) in Postmenopausal Women Anastrozole - DCIS | Phase 2 | Completed | Rita Sanghvi, Mehta | 42 | 2004-09-21 | 2021-05-11 |
| MammoSite as Sole Radiation Therapy Technique for Ductal Carcinoma In-Situ MammoSite Radiation Therapy System - DCIS | Phase 2 | Completed | Hologic, Inc. | 133 | 2003-08-01 | 2012-11-06 |
Carcinoma, Intraductal, Noninfiltrating (12) · Breast Neoplasms (10) · Carcinoma, Ductal, Breast (2)
Adenocarcinoma (12) · Breast Carcinoma In Situ (12) · Carcinoma (12) · Carcinoma in Situ (12) · Neoplasms (12) · Neoplasms by Histologic Type (12) · Neoplasms, Ductal, Lobular, and Medullary (12) · Neoplasms, Glandular and Epithelial (12) · Breast Diseases (10) · Neoplasms by Site (10) · Skin Diseases (10) · Skin and Connective Tissue Diseases (10) · Carcinoma, Ductal (2)
Anastrozole (1) · Biopsy (1) · Chloroquine (1) · palbociclib (1)
Georgetown University (2) · Abramson Cancer Center at Penn Medicine (1) · Hologic, Inc. (1) · Inova Health Care Services (1) · Integro Theranostics (1) · Memorial Sloan Kettering Cancer Center (1) · Ontario Clinical Oncology Group (OCOG) (1) · Rita Sanghvi, Mehta (1) · Robert Bosch Gesellschaft für Medizinische Forschung mbH (RBMF) (1) · UNC Lineberger Comprehensive Cancer Center (1) · University of Wisconsin, Madison (1)
United States (10) · Canada (1) · Germany (1)
Atif J Khan, MD (1) · Bethany Anderson, MD (1) · Brian J Czerniecki, M.D., Ph.D. (1) · Candace Mainor, MD (1) · Dan Thompson (1) · Do-Hoon Kim, MD (1) · Ethan Steele, MD, MS (1) · Kirsten H Edmiston, MD, FACS (1) · Matthias Schwab, Prof. Dr. (1) · Oscar Streeter, MD (1) · Priscilla McAuliffe, MD, PhD (1) · Rita Mehta, MD (1) · Sonali Rudra, M.D. (1)
PMID 20562526, PMID 39378393, PMID 42649946
2016 (1)