1 active not recruiting, 1 completed, 1 terminated, 1 withdrawn. 4 Phase 2.
| Phase | Trials | Status |
|---|---|---|
| Phase 2 | 4 | Active not recruiting 1, Completed 1, Terminated 1, Withdrawn 1 |
Follow BRIP1 Gene Mutation: new trials by email Literature Review of BRIP1 Gene Mutation trials Research Report on BRIP1 Gene Mutation
Tick up to 5 trials to compare them side by side (eligibility, arms, endpoints, adverse events) in a Literature Matrix.
| Trial | Phase | Status | Sponsor | Enrollment | Start | Updated |
|---|---|---|---|---|---|---|
| Niraparib, Abiraterone Acetate and Prednisone for mHSPC With Deleterious Homologous Recombination Repair Alterations Androgen Deprivation Therapy (ADT), Niraparib/Abiraterone Acetate DAT, Abiraterone Acetate - Metastatic Hormone-sensitive Prostate Cancer (mHSPC), Deleterious HRR Gene Mutation | Phase 2 | Withdrawn | Qian Qin | 2025-10-01 | 2026-04-08 | |
| Niraparib Before Surgery in Treating Patients With High Risk Localized Prostate Cancer and DNA Damage Response Defects Niraparib, Niraparib Tosylate Monohydrate, Radical Prostatectomy - ATM Gene Mutation, BRCA1 Gene Mutation | Phase 2 | Terminated | University of California, Davis | 11 | 2020-02-25 | 2026-05-14 |
| Olaparib In Metastatic Breast Cancer Olaparib - Metastatic Breast Cancer, Invasive Breast Cancer | Phase 2 | Active not recruiting | Beth Israel Deaconess Medical Center | 114 | 2018-04-01 | 2026-01-05 |
| Lung-MAP: Talazoparib in Treating Patients With HRRD Positive Recurrent Stage IV Squamous Cell Lung Cancer Laboratory Biomarker Analysis, Pharmacological Study, Talazoparib - ATM Gene Mutation, ATR Gene Mutation | Phase 2 | Completed | SWOG Cancer Research Network | 51 | 2017-03-03 | 2021-06-23 |
Breast Neoplasms (1) · Fanconi Anemia, Complementation Group D1 (1) · Prostatic Neoplasms (1)
Neoplasms (2) · Neoplasms by Site (2) · Breast Diseases (1) · Genital Diseases (1) · Genital Diseases, Male (1) · Genital Neoplasms, Male (1) · Male Urogenital Diseases (1) · Prostatic Diseases (1) · Skin Diseases (1) · Skin and Connective Tissue Diseases (1) · Urogenital Diseases (1) · Urogenital Neoplasms (1)
niraparib (2) · Abiraterone Acetate (1) · Androgen Antagonists (1) · Docetaxel (1) · Prednisone (1) · olaparib (1) · talazoparib (1)
Beth Israel Deaconess Medical Center (1) · Qian Qin (1) · SWOG Cancer Research Network (1) · University of California, Davis (1)
United States (3) · Canada (1)
Marc Dall'Era (1) · Nadine Tung, MD (1) · Qian Qin, MD (1) · Vassiliki Papadimitrakopoulou (1)
PMID 33119476, PMID 36710203, PMID 41604601
P30CA093373 (1), U10CA180888 (1)