AcceXible Speech-Based Screening for Depression and Anxiety in University Students (UAQ, Mexico)

NCT07578142 — Not yet recruiting, 80 participants, Accexible

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Validación Del Sistema de Cribaje y de Seguimiento de Accexible Para depresión y Ansiedad en el Entorno Del Alumnado de la Universidad Autónoma de Querétaro

Registry	NCT07578142
Status	Not yet recruiting
Study type	Observational
Enrollment	80 (Estimated)
Sponsor	Accexible (Industry); collaborators: Universidad Autónoma de Querétaro
Conditions	Depression - Major Depressive Disorder, Anxiety
Interventions	Accexible (Device)
Dates	start 2026-09-05 (estimated), primary completion 2027-09-01 (estimated), completion 2027-09-01 (estimated), first posted 2026-05-11, last updated 2026-05-11
Locations	1 site in Mexico

-Summary

Major depressive disorder (MDD) and anxiety are increasingly prevalent among university student populations, yet early detection remains reliant on psychometric instruments tied to diagnostic criteria (e.g., PHQ-9, GAD). Emerging evidence suggests that depression affects both the acoustic properties and content of speech, making speech analysis a promising candidate as a digital biomarker for early screening.

This study evaluates the validity of acceXible, a speech-based machine learning platform, for the detection and monitoring of depression and anxiety in the student population of the Universidad Autónoma de Querétaro, Mexico. AcceXible captures spontaneous speech through open-ended interview tasks and applies automated acoustic and linguistic analysis.

The primary objective is to evaluate the validity of the acceXible spontaneous speech analysis system for depression and anxiety screening, assessed against the PHQ and GAD scales as reference standards. Secondary objectives include examining associations between speech-derived variables and other study measures, evaluating participant engagement with digital mental health resources, assessing user satisfaction with the platform, and analyzing longitudinal changes in scores across follow-up assessments.

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+Arms and interventions

Accexible (Device): Speech analysis

+Outcome measures

Primary outcomes

Diagnostic accuracy of acceXible for depression and anxiety screening [Baseline]: Sensitivity, specificity, and positive predictive value of the acceXible speech analysis system relative to validated Spanish-language versions of the PHQ-9 and GAD-7 as reference standards. Sensitivity is defined as the probability of correctly classifying a participant with abnormal scores; specificity as the probability of correctly classifying a non-affected participant; and positive predictive value as the probability that a participant flagged by acceXible truly meets criteria for depression or anxiety.

+Eligibility

Sex: All, ages: 16 Years to 25 Years, accepts healthy volunteers

Inclusion Criteria:

* Provision of voluntary written informed consent
* Age 16-25 years
* Current enrollment at BUAP
* Spanish language proficiency
* Access to a mobile device with internet connectivity
* Ability to understand and follow basic acceXible usage instructions

Exclusion Criteria:

* Refusal to participate
* Psychomotor agitation
* Sensory impairment (visual or auditory)
* Cognitive impairment

+Locations (1)

Facility	City	Country	Status
Universidad Autónoma de Querétaro	Querétaro City, Querétaro	Mexico