Excess Base Comparison Between Pregnant Subjects With Severe Preeclampsia vs. Normotensive Pregnant Women

NCT07265336 — Not applicable, Completed, 100 participants, Saint Thomas Hospital, Panama

ClinicalTrials Daily · Areas · Conditions · Drugs · Sponsors ·

Comparison of Base Excess in Arterial Blood Gases Between Patients With Severe Preeclampsia and Normotensive Pregnant Patients

Registry	NCT07265336
Status	Completed
Phase	Not applicable
Study type	Interventional; non randomized, single group, masking: none, diagnostic
Enrollment	100 (Actual)
Sponsor	Saint Thomas Hospital, Panama (Other)
Conditions	Preeclampsia, Severe Preeclampsia
Interventions	Arterial Blood gases (Diagnostic test)
Dates	start 2025-08-15, primary completion 2026-02-20, completion 2026-03-31, first posted 2025-12-04, last updated 2026-07-16
Locations	1 site in Panama

-Summary

The study's primary goal is to compare the base excess (BE) values-an indicator of metabolic changes-in two groups of patients at Santo Tomás Hospital: those with severe preeclampsia and healthy, pregnant individuals. Researchers will measure these values using an arterial blood gas test before delivery or surgery.

This is a prospective cohort study. The researchers will analyze various blood gas parameters, including pH, lactate, and BE, and then correlate the BE values with clinical variables and negative maternal outcomes.

The expected outcome is that a abnormal BE values will be linked to a greater severity of preeclampsia. If this association is confirmed, BE could serve as an additional marker for predicting the severity of the condition and may lay the groundwork for future research on diagnostic and therapeutic standards based on blood gas analysis.

Expand all sections · Collapse all

+Arms and interventions

Arm	Type	Interventions	Description
Severe preeclampsia	Experimental	Diagnostic Test: Arterial Blood gases	Pregnant subjects with severe preeclampsia
Normotensive	Experimental	Diagnostic Test: Arterial Blood gases	Pregnant subjects with normal blood pressure

Arterial Blood gases (Diagnostic test): Determination of Excess Base in arterial blood gases before delivery / termination of pregnancy

+Outcome measures

Primary outcomes

Value of excess base [Immediately before delivery]: Total measure of excess base measured by gasometry in an arterial blood sample
Hypertensive crisis [From admission to day three (3) after delivery]: Elevation of the blood pressure above 160 (systolic) and 110 (diastolic).

Secondary outcomes

Lactate [Immediately before delivery]: Concentration of lactate measured by gasometry in a sample of arterial blood.
Bicarbonate [Immediately before delivery]: Concentration of bicarbonate measured by gasometry in arterial blood gases

+Eligibility

Sex: Female, accepts healthy volunteers

Inclusion Criteria:

* Gestational age: 24-40 weeks
* Cases: Diagnosis of severe preeclampsia
* Control: Normal blood pressure

Exclusion Criteria:

* Metabolic conditions that could hinder the results (diabetic ketoacidosis, sepsis, renal failure).
* Clinical conditions that could hinder the results (diarrhea, vomit)
* Recent use of bicarbonate

+Locations (1)

Facility	City	Country	Status
Saint Thomas Hospital	Panama City, Provincia de Panamá	Panama

+Investigators

Osvaldo Reyes, MD, Study chair, Saint Thomas Hospital, Panama