| Registry | NCT06707714, acronym Metabolomics |
|---|---|
| Status | Unknown |
| Study type | Observational |
| Enrollment | 150 (Estimated) |
| Sponsor | Dong Peng (Other) |
| Conditions | Metabolic Syndrome, Gastric Cancer |
| Interventions | hypertension, diabetes, fatty liver (Diagnostic test) |
| Dates | start 2023-07-01, primary completion 2026-07-01 (estimated), completion 2026-07-01 (estimated), first posted 2024-11-27, last updated 2024-11-27 |
| Locations | 1 site in China |
Related Papers Related Patents Related Grants Related Experts
All trials for Metabolic Syndrome All trials for Gastric Cancer All trials of hypertension All trials of diabetes
1. Analysis of preoperative and postoperative metabolite changes: Through metabolomics technology, the changes of preoperative and postoperative metabolites in patients with gastric cancer complicated with metabolic syndrome were systematically analyzed, and the key metabolites related to the remission of hypertension, hyperlipidemia, and diabetes after surgery were found.
2. Explore the influencing factors of postoperative remission of metabolic syndrome: Combined with clinical data, the association between various metabolites and the degree of postoperative remission was evaluated, and the main factors affecting postoperative remission were determined.
3. Reveal the mechanism of postoperative remission of metabolic syndrome: through multi-level metabolomics analysis, to clarify the metabolic pathways and mechanisms involved in the process of postoperative remission, and provide a new theoretical basis for the development of tumor metabolic surgery.
This project will last 2-3 years. All patients who meet the inclusion and exclusion criteria will be divided into three groups according to the type of metabolic syndrome, including hypertension, diabetes and hyperlipidemia, with 50 cases in each group. Blood and feces of all patients were collected before surgery, 3 days after surgery, 6 months after surgery, and 1 year after surgery. The collected samples will be subjected to untargeted metabolomics analysis, using NMR-IVDr technology to detect the dynamic changes of all small molecular metabolites (mainly endogenous small molecular compounds with relative molecular weight within 1000 Da) in blood and feces before and after stimulation or disturbance without bias. The differential metabolites of blood glucose, blood lipid, cholesterol, insulin, renin, aldosterone, and angiotensin were screened by bioinformatics analysis, and the pathway analysis of differential metabolites was performed to reveal the potential physiological mechanism of postoperative hypertension, diabetes, and hyperlipidemia
| Arm | Type | Interventions | Description |
|---|---|---|---|
| Gastric cancer patients combine with hypertension | Diagnostic Test: hypertension | Gastric cancer patients diagnosed with hypertension | |
| Gastric cancer patients combine with diabetes | Diagnostic Test: diabetes | Gastric cancer patients diagnosed with diabetes | |
| Gastric cancer patients combine with fatty liver | Diagnostic Test: fatty liver | Gastric cancer patients diagnosed with fatty liver |
Sex: All, ages: 18 Years to any, accepts healthy volunteers
Inclusion Criteria: * 1\. Age >18 years old. 2. Patients with hypertension or diabetes for more than 1 year before surgery. 3. Patients undergoing radical gastrectomy for gastric cancer. Exclusion Criteria: * 1\. Gastric stump cancer. 2. Patients with distant metastasis. 3. Patients who underwent combined resection of other important organs. 4. Severe postoperative complications. 5. Patients who are using drugs that may significantly affect metabolic status (such as hormonal drugs, potent immunosuppressants, etc.). 6. Incomplete clinical data.
| Facility | City | Country | Status |
|---|---|---|---|
| Chongqing Medical University | Chongqing, Chongqing Municipality | China |