| Registry | NCT06687525 |
|---|---|
| Status | Active not recruiting |
| Study type | Observational |
| Enrollment | 240 (Estimated) |
| Sponsor | University of Illinois at Urbana-Champaign (Other) |
| Conditions | Alcohol Drinking, Alcohol Use Disorder, Alcohol Intoxication, Alcohol; Harmful Use, Alcoholism, Binge Drinking |
| Dates | start 2024-04-05, primary completion 2026-01-26, completion 2028-06-01 (estimated), first posted 2024-11-13, last updated 2026-05-04 |
| Locations | 1 site in United States |
Related Papers Related Patents Related Grants Related Experts
All trials for Alcohol Drinking All trials for Alcohol Use Disorder
In this study, the investigators aim to capture inter- and intra-brain mechanisms underlying alcohol reward in novel social context.
Objective: Alcohol's ability to boost mood in the face of stress is perhaps its most notoriously addictive property, long held by researchers to be of critical importance for understanding alcohol use disorder (AUD) etiology. Yet, while most real-world alcohol consumption occurs in social settings, in the context of laboratory studies, participants have almost always consumed alcohol alone. The discrepancy between real-world and laboratory contexts emerges as particularly stark in the neuroimaging literature, where no alcohol-administration study to date has incorporated in-vivo social context. In this first alcohol-administration study to leverage EEG hyperscanning methods, the investigators aim to capture inter- and intra-brain mechanisms underlying alcohol reward in novel social context.
Specifically, this study aims to characterize the mechanisms driving social reward from alcohol in the context of stress and elucidate the role of social processes and novel social context in driving problem drinking.
Study Population: Participants will consist of 240 regular drinkers, aged 21-30, with no reported history of severe alcohol use disorder.
Design: In the laboratory arm of the study, individuals will be randomly assigned to consume either a moderate dose of alcohol or a control beverage in stranger dyads. Participants will engage in both structured and unstructured tasks aimed at assessing social engagement and threat sensitivity. EEG and ERP data will be collected from both participants simultaneously. In the ambulatory study arm, participants will wear transdermal sensors to assess BAC and will further provide information about their mood and their social contexts in response to random prompts.
Outcome Measures: Primary outcome measures include EEG measures of inter-brain entrainment as well as ERP metrics derived from task contexts (both players and observers). Additional outcomes include measures of positive mood, negative mood, and social bonding. Finally, drinking behaviors will be assessed via transdermal ambulatory alcohol sensors and longitudinal self-reports of drinking.
Sex: All, ages: 21 Years to 30 Years, accepts healthy volunteers
Inclusion Criteria: * Between the ages of 21 and 30 * Regularly consumes alcohol Exclusion Criteria: * History of adverse reaction to the amount of beverage employed in the study * Have a history of major problems associated with alcohol * Take medications that could adversely interact with alcohol * Have medical conditions that contraindicate alcohol administration * Individuals with a history of skull fractures or who indicate discomfort with EEG procedures used * Female participant is pregnant or trying to become pregnant
| Facility | City | Country | Status |
|---|---|---|---|
| University of Illinois at Urbana-Champaign | Champaign, Illinois | United States |